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Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study

Matthew K Hensley, et al.

A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. 

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A Cold Case
Amanda K Hempel et al.
A previously healthy 33-year-old man presented to the emergency department with a 3-month history of 2 painless, enlarging masses on his back. He did not report fever, chills, weight loss, or night sweats. There were no associated respiratory or neurologic symptoms. He was born in Trinidad and Tobago but had moved to ...
In the Literature
Andrade CM, Fleckenstein H, Thomson-Luque R, et al. Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season. Nat Med 2020;26(12):1929–40. doi: 10.1038/s41591-020-1084-0. Epub ahead of print: 26 October 2020. PMID: 33106664. In Mali, as in other areas of ...
Reinfection Rates among Patients who Previously Tested Positive for COVID-19: a Retrospective Cohort Study
Megan M Sheehan, BS et al.
Background Protection afforded from prior disease among patients with coronavirus disease 2019 (COVID-19) infection is unknown. If infection provides substantial long-lasting immunity, it may be appropriate to reconsider vaccination distribution plans. Methods This retrospective cohort study of one multi-hospital health ...
A Phase 3, Randomized, Double-Blind Study Comparing Tedizolid Phosphate and Linezolid for Treatment of Ventilated Gram-Positive Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia
Richard G Wunderink et al.
Tedizolid was noninferior to linezolid for all-cause mortality in the treatment of ventilated gram-positive hospital-acquired or ventilator-associated bacterial pneumonia. Noninferiority of tedizolid to linezolid for investigator-assessed clinical response at test of cure was not demonstrated. Both drugs were well tolerated.
Plasma kynurenine-to-tryptophan ratio, a highly sensitive blood-based diagnostic tool for Tuberculosis in HIV-infected pregnant women
Clement Adu-Gyamfi et al.
Background For pregnant women living with human immunodeficiency virus (HIV), concurrent active Tuberculosis (TB) disease increases the risk of maternal mortality and poor pregnancy outcomes. Plasma indoleamine 2,3-dioxygenase (IDO) activity, measured by kynurenine-to-tryptophan (K/T) ratio has been proposed as a ...

Editor's Choice

John Bartlett, In Memoriam
Sherwood L Gorbach
In the many tributes that have poured in since the passing of John Bartlett on January 19, 2021, the phrase that reverberates is “the passing of a legend.” I had known John for 50 years since we met in 1970 and worked closely with him for 8 years, initially at Sepulveda VA Hospital in California and then at Tufts Medical ...
Molecular Testing for Acute Respiratory Tract Infections: Clinical and Diagnostic Recommendations From the IDSA’s Diagnostics Committee
Kimberly E Hanson et al.
Molecular assays have revolutionized the diagnosis of acute respiratory tract infections. However, many unanswered questions about the optimal use and cost-effectiveness of these tests remain. Additional prospective diagnostic studies are needed to measure impact on medical decision making and clinical outcomes.
We Need to Address the Health of Children at the Border
Betsy C Herold et al.
Military guidance emphasizes the importance of immunization in the prevention of respiratory disease outbreaks [ 15 ]. It is therefore particularly egregious that our government has chosen to withhold influenza vaccine from individuals in border detention facilities. On 21 August 2019, the Pediatric Infectious Diseases ...
A “Natural Death”: The Political Battlefield of Infections and Migrant Children’s Bodies
Mark A Travassos
Recent deaths of migrant children from overwhelming infections in US detainment centers have brought to light outbreaks in these facilities, delays in medical care, and inadequate medical expertise. Advocacy by clinicians and professional societies is critical to resolving this crisis.
Development of Daptomycin Susceptibility Breakpoints for Enterococcus faecium and Revision of the Breakpoints for Other Enterococcal Species by the Clinical and Laboratory Standards Institute
Michael J Satlin et al.
Daptomycin is one of the few treatment options for infections caused by enterococci that are resistant to ampicillin and vancomycin, such as vancomycin-resistant Enterococcus faecium . The emergence and clinical significance of daptomycin-resistant enterococci and evolving microbiologic, pharmacokinetic-pharmacodynamic, ...
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Cover image of current issue from The Journal of Infectious DiseasesThe Journal of Infectious Diseases Cover image of current issue from Open Forum Infectious DiseasesOpen Forum Infectious Diseases Journal of the Pediatric Infectious Diseases Society Cover image of current issue from Journal of Antimicrobial ChemotherapyJournal of Antimicrobial Chemotherapy Cover image of current issue from American Journal of EpidemiologyAmerican Journal of Epidemiology Virus Evolution Virus Evolution Journal of Travel Medicine Cover image of current issue from Oxford Open ImmunologyOxford Open Immunology
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