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Daniel B Chastain, George R Thompson, Andrés F Henao-Martínez, Glucocorticoids, Concomitant Immunosuppression, and PJP Prophylaxis Among U.S. Adults, Clinical Infectious Diseases, 2025;, ciaf147, https://doi.org/10.1093/cid/ciaf147
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Abstract
The impact of glucocorticoids, comorbidities, and immunosuppressive therapies on Pneumocystis jirovecii pneumonia (PJP) risk remains understudied, and prophylaxis is underutilized. Among U.S. adults in TriNetX prescribed glucocorticoids for ≥2 weeks in TriNetX, 44.6% received >20mg prednisone equivalents/day. Prophylaxis rates were low, with higher glucocorticoid doses associated with lower prophylaxis odds.
Glucocorticoids, Immunosuppressive Agents, Biological Therapy, Immunomodulation, Pneumonia, Pneumocystis, Opportunistic Infections
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