Abstract

The impact of glucocorticoids, comorbidities, and immunosuppressive therapies on Pneumocystis jirovecii pneumonia (PJP) risk remains understudied, and prophylaxis is underutilized. Among U.S. adults in TriNetX prescribed glucocorticoids for ≥2 weeks in TriNetX, 44.6% received >20mg prednisone equivalents/day. Prophylaxis rates were low, with higher glucocorticoid doses associated with lower prophylaxis odds.

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