Antimicrobial Stewardship in a Pandemic: Picking Up the Pieces

EDITORIAL COMMENTARY • cid 2020:XX (XX XXXX) • 1 Received 20 August 2020; editorial decision 21 August 2020; accepted 24 August 2020; published online August 28, 2020. Correspondence: C. J. Graber, Infectious Diseases Section, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, 111-F, Los Angeles, CA 90073 (christopher.graber@ va.gov). Clinical Infectious Diseases 2020;XX(XX):1–3 Published by Oxford University Press for the Infectious Diseases Society of America 2020. This work is written by (a) US Government employee(s) and is in the public domain in the US. DOI: 10.1093/cid/ciaa1273 Antimicrobial Stewardship in a Pandemic: Picking Up the Pieces

Coincident with the onset of the coronavirus disease 2019  pandemic, studies have demonstrated higher rates of inpatient utilization of overall, broad-spectrum, and narrowspectrum antibiotics [1,2]. In this issue of Clinical Infectious Diseases, Vaughn and colleagues reviewed antibiotic utilization and rates of bacterial coinfection for patients hospitalized with COVID-19 at 38 hospitals in Michigan that were enrolled in a statewide multi-institutional collaborative quality initiative specifically aimed at improving care for patients hospitalized with COVID-19 [3]. Of 1705 reviewed patients admitted with COVID-19, 56.6% received empiric antibiotic therapy, despite only 3.5% having a documented community-onset bacterial coinfection. Although this large discordance between rates of antibiotic use and bacterial coinfection with COVID-19 has been described in the literature [4,5], this study adds further validation to the existing body of evidence given its large multicenter study design and its detailed analysis of descriptive data on initial patient characteristics, empiric antibiotic choice and duration, and type of infection early in the hospitalization, as well as risk factors for empiric antibiotic use and community-acquired bacterial coinfection.
The authors conclude that "given the potential harms to patients and society from unnecessary antibacterial use . . . it is imperative that we develop strategies to help clinicians prescribe antibacterials judiciously to hospitalized patients with COVID-19. " So, what should these strategies be? Strategies that antimicrobial stewardship programs (ASPs) can devise are best conceptualized according to phases of inpatient management of COVID-19 disease:  [6], and this study suggests that a similar pattern is observed with patients with COVID-19. ASPs should therefore focus their efforts on increasing testing capacity so that providers can rapidly identify patients with COVID-19 and potentially prevent unnecessary antibiotic prescription. This rapid identification can also be coupled with timely communication and decision support by ASP.
In cases of bacteremia, rapid diagnostics are most effective when coupled with decision support from ASP [7], and although interpretation of COVID-19 tests is in no way as complex as the multiplex PCR panels used for bacteremia, there is still likely a role for ASPs to help providers ascertain risk factors for bacterial coinfections and need for antibiotics in the setting of a positive COVID-19 test, particularly in patients presenting with mild to moderate disease. Respiratory culture is another point of ASP focus during the first phase of management. However, obtaining respiratory cultures must be done while balancing the risk of aerosolization from performing diagnostic procedures like bronchoalveolar lavage or induced sputum. The authors noted that only 7.7% of patients had respiratory cultures obtained and speculated that fear of aerosolization may have contributed to the low rate. Given this, ASPs can additionally engage in diagnostic stewardship to optimize utility of respiratory cultures. In keeping with 2019 community-acquired pneumonia treatment guideline, even for patients presenting with confirmed COVID-19, those who are most likely to benefit from cultures are likely those presenting with severe disease or those empirically treated with broad-spectrum antibiotics [8,9]. Disease severity was identified as a risk factor for bacterial coinfection in this study, which further supports the idea that respiratory culture should be prioritized for those presenting with severe disease.

48-96 HOURS INTO HOSPITALIZATION
Although Vaughn et al note that the most common empiric antibiotics prescribed were antibiotics with communityacquired coverage, 12.5% of patients were given anti-methicillin-resistant Staphylococcus aureus (MRSA) antibiotics, and 14.9% were given antipseudomonal antibiotics. Although the study did not evaluate appropriateness of these broad-spectrum agents, this finding suggests that there is a role for ASPs to help deescalate antibiotics 48-96 hours into the hospitalization based on assessment of risk factors and culture data. This again speaks to the importance of obtaining initial cultures as described above. In cases of bacterial pneumonia, studies have demonstrated clinical benefits and safety with deescalation of antibiotics [10][11][12]. The same principle should apply for patients with COVD-19 and bacterial coinfection.
One unique difference between patients with bacterial community-acquired pneumonia and patients with COVID-19 is that depending on diagnostic data, stopping antibiotics completely after 48-96 hours may be appropriate. Vaughn et al showed that 54.4% of patients started on empiric antibiotics had their antibiotics discontinued within 1 day after COVID-19 testing returned positive. Furthermore, 35.9% of patients who were continued on antibiotics and did not have confirmed community-onset bacterial coinfection had antibiotics discontinued within 5 days, a duration shorter than what is recommended for treatment of bacterial pneumonia. Although the study did not provide any outcome data as it pertains to duration of antibiotics, the data suggest that early discontinuation of antibiotics is feasible and likely appropriate for patients with COVID-19, particularly considering the low rates of bacterial coinfection observed in this study.

BEYOND 96 HOURS
The authors also found that 24.5% of patients without bacterial coinfection received antibiotics for >7 days, a duration longer than what is typically recommended even for hospital-acquired or ventilator-associated pneumonia. The study did not include clinical data beyond the first 2 days of hospitalization; thus, it is unclear if clinical circumstance were present that may have justified the prolonged antibiotic course. Regardless, even prior to the pandemic, excessive treatment duration for pneumonia has been identified as a stewardship target [13][14][15], and the same stewardship efforts should be continued for patients with COVID-19 with concurrent bacterial coinfection.
ASP responsibility does not end with completion of the initial course of antibiotics prescribed to patients. Often patients with COVID-19 experience prolonged hospital courses, with many days on the ventilator, increasing the risk of hospital-acquired infections. ASPs should continue to be involved with the clinical care of patients and assist providers in differentiating colonization from true infection, assessing need for antibiotic therapy, and prescribing the most optimal antibiotics at the right dose, route, and duration.
Vaughn et al bring attention to an important and unfortunate by-product of the COVID-19 pandemic: indiscriminate prescribing of antibiotics for patients hospitalized with COVID-19. For this, the pandemic has brought a new and unique demand for antimicrobial stewardship. However, this demand comes at a time when stewards are in need of more dedicated time and resources to support their ASP efforts, as many have played a key role in their facilities' pandemic response, spending countless hours on COVID-19-specific policies and guidelines at the expense of usual ASP activities. As the COVID-19 pandemic continues to evolve, an important challenge to address will be how best to support the resumption of ASPs so that they can "pick up the pieces" in limiting indiscriminate antimicrobial use.