“Facing COVID-19” by CDC Emergency Response and Creative Team Since we first heard about a novel coronavirus half a world away—a virus that was later named SARS-CoV-2—local, state, and federal health agencies; public health agencies across the globe; partners; physicians; and the entire world have been facing COVID-19 head on. We worked to develop new guidance to help protect people: older adults, pregnant people, athletes, nursing home residents, ethnic and racial minorities, children, and so many more. In the pre-vaccination era, we gained a deep appreciation for the importance of widespread accessibility to SARS-CoV-2 testing and provided data and platforms to support viral testing, serologic tests, rapid tests, and at-home tests. We developed mitigation strategies that achieved unprecedented global adoption. As a public health enterprise, hand-in-hand with our frontline healthcare workers and pharmaceutical partners, we spearheaded rapid distribution of COVID-19 vaccines. Through it all, selfless public health response workers and frontline providers everywhere have and continue to face this public health threat with true dedication.