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Journal Article
ACCEPTED MANUSCRIPT
Corinne E Bovee and others
Endocrinology, bqaf075, https://doi.org/10.1210/endocr/bqaf075
Published: 16 April 2025
Journal Article
ACCEPTED MANUSCRIPT
Stephanie C Bohaczuk and others
Endocrinology, bqaf073, https://doi.org/10.1210/endocr/bqaf073
Published: 16 April 2025
Journal Article
ACCEPTED MANUSCRIPT
Nour Abou Nader and others
Endocrinology, bqaf077, https://doi.org/10.1210/endocr/bqaf077
Published: 15 April 2025
Journal Article
ACCEPTED MANUSCRIPT
Catherine M Rojas and others
Endocrinology, bqaf074, https://doi.org/10.1210/endocr/bqaf074
Published: 15 April 2025
Journal Article
Endocrinology, Volume 166, Issue 5, May 2025, bqaf068, https://doi.org/10.1210/endocr/bqaf068
Published: 11 April 2025
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Published: 11 April 2025
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Published: 11 April 2025
Journal Article
Jennifer C Hutchison and others
Endocrinology, Volume 166, Issue 5, May 2025, bqaf054, https://doi.org/10.1210/endocr/bqaf054
Published: 10 April 2025
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Published: 10 April 2025
Figure 2. MALDI-MSI reveals intratesticular localization of differentially abundant lipids in morphologically normal regions of Inha KO testes. Lipids altered in the Inha KO (n = 2) testes compared with WT (n = 2) are visualized in the interstitial space (B), tubule perimeter (C, D, E), and intratubular spa
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Published: 10 April 2025
Figure 3. MALDI-MSI and whole testis homogenates identify differentially abundant lipids in Inha KO vs WT testes, shown in relationship to tumor proximity. Testis section images show individual lipids, m/z ± 15 ppm, and tentative lipid identification. Inset box and whisker plots show MetaboAnalyst-normaliz
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Published: 10 April 2025
Figure 5. Chronic activin A elevation results in regionally altered testis steroid production. (A) Transcripts encoding steroidogenic enzymes measured by qRT-PCR. Graphs show mean ± SD transcript quantity normalized to Rplp0 in the whole WT (n = 4; grey) and Inha KO testis (n = 3; orange). (B) Intratesticu
Journal Article
ACCEPTED MANUSCRIPT
Adam S Knier and Stephanie Olivier-Van Stichelen
Endocrinology, bqaf072, https://doi.org/10.1210/endocr/bqaf072
Published: 10 April 2025
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Published: 10 April 2025
Figure 8. Excess activin A affects adrenal gland reveals subtle effects of excess activin A on cell metabolism. (A) In the wild type adrenal gland, lipid droplets accumulate in the cortex, but are sparse in the adrenal medulla, and the Inha KO adrenal (B) was not obviously different. (C) Transcripts encoding
Journal Article
ACCEPTED MANUSCRIPT
Serene Joseph and others
Endocrinology, bqaf071, https://doi.org/10.1210/endocr/bqaf071
Published: 10 April 2025
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Published: 10 April 2025
Figure 1. Testicular lipid profile is affected by chronic activin A excess. (A) In WT testes (n = 3), lipid droplet (LDs) are prominent in in spermatids (tubule) and Leydig cells (interstitium). In Inha KO testes (n = 5), LDs are present in spermatids in “normal” tubules (N) and in the interstitium (B). Tubu
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Published: 10 April 2025
Figure 4. Excess activin A changes testicular metabolism. (A) PCA (A i ) and PLSDA (A ii ) show discrete profiles of metabolites detected in WT (green, n = 7) and Inha KO (purple, n = 6) testes. (B) Fifty-four metabolites were significantly higher in Inha KO testes, and 10 were lower. (C) Heat map analysis
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Published: 10 April 2025
Figure 6. Proximity to the Inha KO tumors influences the pathways enriched in gene expression and cell metabolism relative to WT testes. Visual representation of joint pathway analysis utilizing the differentially abundant whole testis metabolites in conjunction with unique DEGs of the morphologically normal
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Published: 10 April 2025
Figure 7. Abnormal lipid deposition and steroid production phenotype in Inha KO ovaries. (A) In WT ovaries (n = 4), Oil Red O staining identifies lipid deposition in the stroma (S; A i ), granulosa cells of primary and secondary follicles (1°, 2°, respectively; A ii ), and in the mural, but not cumulus, gran
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Published: 08 April 2025
Journal Article
Endocrinology, Volume 166, Issue 5, May 2025, bqaf044, https://doi.org/10.1210/endocr/bqaf044
Published: 08 April 2025