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endometriosis

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Journal Articles
Published: 23 February 2017
...L Kuessel; R Wenzl; K Proestling; S Balendran; P Pateisky; Yotova, I; G Yerlikaya; B Streubel; H Husslein AbstractSTUDY QUESTIONDo cell adhesion molecules play a role in endometriosis, and can they be used as a biomarker for diagnosing endometriosis?SUMMARY ANSWERAltered expression of vascular...
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Journal Articles
Published: 18 February 2017
... vascular tissue and the support of tissue growth and vascularization. The use of anti-angiogenic drugs appears as a possible therapeutic strategy against endometriosis.STUDY DESIGN, SIZE, DURATIONThis is an in vitro study comprising patients receiving surgical treatment of ovarian endometriosis (n = 9...
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Journal Articles
Published: 23 January 2017
...Neil P. Johnson; Lone Hummelshoj; G. David Adamson; Jörg Keckstein; Hugh S. Taylor; Mauricio S. Abrao; Deborah Bush; Ludwig Kiesel; Rulla Tamimi; Kathy L. Sharpe-Timms; Luk Rombauts; Linda C. Giudice; for the World Endometriosis Society Sao Paulo Consortium AbstractSTUDY QUESTIONWhat...
Journal Articles
Published: 09 February 2017
...Yanbo Du; Xishi Liu; Sun-Wei Guo AbstractSTUDY QUESTIONDo platelets have any role in the reduced cytotoxicity of natural killer (NK) cells in endometriosis?SUMMARY ANSWERPlatelets impair NK cell reactivity and function in endometriosis through multiple mechanisms.WHAT IS KNOWN ALREADYPlatelets...
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Journal Articles
Published: 23 January 2017
... with endometriosis?SUMMARY ANSWERThe levels of total cMP, but not cMP-TF, were higher in patients with endometriosis, and these were attributed to higher levels in patients with deep infiltrating endometriosis (DIE).WHAT IS KNOWN ALREADYPrevious studies have reported elevated levels of total cMP in inflammatory...
Journal Articles
Published: 23 January 2017
... foci of patients with endometriosis.WHAT IS KNOWN ALREADYSeveral studies have demonstrated the overexpression of low-density lipoprotein receptors in various tumour cell lines and endometriosis has similar aspects to cancer, mainly concerning the pathogenesis of both diseases. This is the first study...
Journal Articles
Published: 22 February 2017
... and case series. No age restriction was applied. Exclusion criteria were patients suffering from tubal infertility from any other reason (e.g. infection, endometriosis and adhesions from previous surgery) and studies including <10 participants. The following factors likely to influence the success...
Journal Articles
Published: 15 February 2017
... for endometriosis (range 8000–23 000) and, for such patients, only slightly dependent on female age and duration of infertility.WHAT IS KNOWN ALREADYA few countries have guidelines for indications of IVF, using the diagnostic category, female age and duration of infertility. The CE of these guidelines is unknown...
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Journal Articles
Published: 08 February 2017
... genetic effects on endometriosis risk and other endometrial-related pathologies.Study funding/competing interest(s)Funding for this work was provided by NHMRC Project Grants GNT1026033, GNT1049472, GNT1046880, GNT1050208, GNT1105321 and APP1083405. There are no competing interests. We compared...
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Journal Articles
Published: 16 December 2016
...Ming Yuan; Dong Li; Min An; Qiuju Li; Lu Zhang; Guoyun Wang STUDY QUESTIONWhat are the features of peritoneal macrophage subgroups and T helper cells in the development of murine endometriosis?SUMMARY ANSWERDuring the development of endometriosis in a murine model, large peritoneal macrophages...
Journal Articles
Published: 16 December 2016
...Ana-Maria Sanchez; Federica Quattrone; Maria Pannese; Adele Ulisse; Massimo Candiani; Javier Diaz-Alonso; Guillermo Velasco; Paola Panina-Bordignon STUDY QUESTIONDoes signaling via the cannabinoid (CB1) receptor play a role in the pathogenesis of endometriosis in a mouse model?SUMMARY ANSWERMice...
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Journal Articles
Published: 17 November 2016
...Laura Benaglia; Giorgio Candotti; Enrico Papaleo; Luca Pagliardini; Marta Leonardi; Marco Reschini; Lavinia Quaranta; Maria Munaretto; Paola Viganò; Massimo Candiani; Paolo Vercellini; Edgardo Somigliana STUDY QUESTIONAre women with endometriosis who conceive with IVF at increased risk of preterm...
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Journal Articles
Published: 21 October 2016
...Qiqi Long; Xishi Liu; Qiuming Qi; Sun-Wei Guo STUDY QUESTIONDoes chronic stress in mice accelerate the development of endometriosis, and, if so, through what mechanism?SUMMARY ANSWERExposure to chronic stress accelerates the development of endometriosis and exacerbates the endometriosis-associated...
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Journal Articles
Published: 21 October 2016
...A.A. De Graaff; J. Van Lankveld; L.J. Smits; J.J. Van Beek; G.A.J. Dunselman STUDY QUESTIONTo what extent are endometriosis and its related physical and mental symptoms associated with the perceived level of sexual functioning in women and their male partners?SUMMARY ANSWERDyspareunia...
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Journal Articles
Published: 21 October 2016
... homology A  and vascular endothelial growth factor A (VEGF-A).WHAT IS KNOWN ALREADYA variety of miRNAs are demonstrated to involve in the pathogenesis of endometriosis. miR-503 is a miRNA with tumor-suppressor functions, whose expression is suppressed in ECSCs.STUDY DESIGN, SIZE, DURATIONWe isolated ECSCs...
Journal Articles
Published: 21 October 2016
...Min Zhou; Jing Fu; Li Xiao; Shiyuan Yang; Yong Song; Xianghui Zhang; Xue Feng; Huaqin Sun; Wenming Xu; Wei Huang STUDY QUESTIONDo microRNAs (miRNAs) contribute to aberrant progesterone receptor (PGR) expression in the eutopic endometrium of women with endometriosis?SUMMARY ANSWERmiR-196a...
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Journal Articles
Published: 20 October 2016
... gynecologic disorders are involved. Coital pain is among the main factors that affect sexual functioning, and this symptom is reported by almost half of women suffering from endometriosis. However, sexuality is a complex phenomenon driven by social, psychological and biological/hormonal factors...
Journal Articles
Published: 17 September 2016
...), a biomarker of the in-utero prenatal hormonal environment, associated with the presence of endometriomas and deep infiltrating endometriosis (DIE)?SUMMARY ANSWERShorter AGD is associated with presence of endometriomas and DIE.WHAT IS KNOWN ALREADYIt is debated whether hormonal exposure to estrogens in utero...
Journal Articles
Published: 17 September 2016
...A. Nishimoto-Kakiuchi; S. Netsu; S. Matsuo; S. Hayashi; T. Ito; S. Okabayashi; L. Yasmin; K. Yuzawa; O. Kondoh; A. Kato; M. Suzuki; R. Konno; T. Sankai AbstractSTUDY QUESTIONWhat are the characteristics of spontaneous endometriosis in cynomolgus monkeys?SUMMARY ANSWERSpontaneous endometriosis...
Journal Articles
Published: 06 September 2016
...Vicky J. Young; Syed F. Ahmad; Jeremy K. Brown; W. Colin Duncan; Andrew W. Horne AbstractSTUDY QUESTIONIs inhibitor of DNA-binding protein 2 (ID2) a mediator of the transforming growth factor (TGF)-β1-induced Warburg-like effect seen in the peritoneum of women with endometriosis?SUMMARY ANSWERThe...