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Figure 2 Blood biomarkers of mitral regurgitation/mitral valve prolapse incidence, severity, progression, and clinical outcomes. Apo-A1, apolipoprotein-A1; BNP, B-type natriuretic peptide; Lp(a), lipoprotein(a); MR, mitral regurgitation; MVP, mitral valve prolapse; PBP, platelet basic protein; PMR, primary m

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Biomarkers of structural valve deterioration. Apo-B, apolipoprotein-B; ApoB... Get access

in Blood biomarkers in left-sided valvular heart disease

Published: 22 April 2025

Figure 4 Biomarkers of structural valve deterioration. Apo-B, apolipoprotein-B; ApoB/ApoA, apolipoprotein-B/apolipoprotein-A; BMP-2, bone morphogenetic protein 2; Cfa1, cyclopropane-fatty-acid-phospholipid synthase 1; cMGP, activated matrix-Gla-protein; FGF-23, fibroblast growth factor 23; HVD, haemodynamic

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in Social factors, health policy, and environment: implications for cardiovascular disease across the globe

Published: 22 April 2025

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Environmental factors that have been linked to human behaviours and establi...

in Social factors, health policy, and environment: implications for cardiovascular disease across the globe

Published: 22 April 2025

Figure 1 Environmental factors that have been linked to human behaviours and established risk factors that cause cardiovascular diseases. Reprinted with permission from Chow et al . 7

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Fruit and vegetable servings per day (bars) and affordability (line) by cou...

in Social factors, health policy, and environment: implications for cardiovascular disease across the globe

Published: 22 April 2025

Figure 4 Fruit and vegetable servings per day (bars) and affordability (line) by country income level. *Affordability is the percentage of household income spent to purchase two servings of fruit and three servings of vegetables per day. HIC, high-income country; UMIC, upper middle-income country; LMIC, lowe

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Percentage availability of aspirin, β-blockers, angiotensin-converting enzy...

in Social factors, health policy, and environment: implications for cardiovascular disease across the globe

Published: 22 April 2025

Figure 8 Percentage availability of aspirin, β-blockers, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and statins. P for trend < .0001 across country income levels (excluding India due to large generic pharmaceutical industry) for both urban and rural areas. n , total numb

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Proposed algorithm for the management of acute pulmonary embolism. CTPA, co... Get access

in Acute right ventricular failure: pathophysiology, aetiology, assessment, and management

Published: 22 April 2025

Figure 6 Proposed algorithm for the management of acute pulmonary embolism. CTPA, computed tomography pulmonary angiography; ECMO, extracorporeal membrane oxygenation; PE, pulmonary embolism; PERT, pulmonary embolism response team; PESI, pulmonary embolism severity index; RV, right ventricular.

Journal Article

Nuclear receptor Dax1 promotes atherosclerosis by lipid transport inhibition and autophagy suppression in macrophages Get access

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Feifei Li and others

European Heart Journal, ehaf241, https://doi.org/10.1093/eurheartj/ehaf241

Published: 22 April 2025

Supplementary data

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Structured Graphical Abstract

in Incident hyperkalaemia risk model in chronic kidney disease and diabetes: the FIDELITY programme

Published: 22 April 2025

Structured Graphical Abstract Structured Graphical Abstract

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2′-Deoxycytidine enhances autophagy and reduces lipid accumulation by inhib... Get access

in Nuclear receptor Dax1 promotes atherosclerosis by lipid transport inhibition and autophagy suppression in macrophages

Published: 22 April 2025

Figure 7 2′-Deoxycytidine enhances autophagy and reduces lipid accumulation by inhibiting Dax1. ( A ) Representative immunoblotting images of Dax1 protein expression in peritoneal macrophages from wild-type mice treated with 0–160 μM 5-Aza-2′-deoxycytidine (5-aza-dC) and 2′-deoxycytidine (2′-dC), respectivel

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Graphical Abstract Get access

in Blood biomarkers in left-sided valvular heart disease

Published: 22 April 2025

Graphical Abstract Graphical Abstract

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Blood biomarkers of aortic stenosis incidence, severity, progression, and c... Get access

in Blood biomarkers in left-sided valvular heart disease

Published: 22 April 2025

Figure 1 Blood biomarkers of aortic stenosis incidence, severity, progression, and clinical outcomes. Apo-B, apolipoprotein-B; Apo-CIII, apolipoprotein-CIII; Apo-(a), apolipoprotein-(a); AVR, aortic valve replacement; AS, aortic stenosis; BNP, B-type natriuretic peptide; CA-125, cancer antigen 125; CRP, C-re

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Four-chamber apical right ventricular-focused view to ‘eyeball’ right ventr... Get access

in Acute right ventricular failure: pathophysiology, aetiology, assessment, and management

Published: 22 April 2025

Figure 3 Four-chamber apical right ventricular-focused view to ‘eyeball’ right ventricular size and function. Right ventricular size is calculated by measuring the end-diastolic basal diameter of the right ventricle. Longitudinal function assessment includes the tricuspid annular plane systolic excursion mea

Journal Article

Incident hyperkalaemia risk model in chronic kidney disease and diabetes: the FIDELITY programme

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João Pedro Ferreira and others

European Heart Journal, ehaf258, https://doi.org/10.1093/eurheartj/ehaf258

Published: 22 April 2025

Supplementary data

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Derivation of risk score in placebo arm: distribution of the integer risk s...

in Incident hyperkalaemia risk model in chronic kidney disease and diabetes: the FIDELITY programme

Published: 22 April 2025

Figure 2 Derivation of risk score in placebo arm: distribution of the integer risk score*. *Data based on the safety analysis set from the placebo treatment arm of FIDELITY

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Macrophage-specific Dax1 knockout alleviates AAV8-PCSK9-induced atheroscler... Get access

in Nuclear receptor Dax1 promotes atherosclerosis by lipid transport inhibition and autophagy suppression in macrophages

Published: 22 April 2025

Figure 2 Macrophage-specific Dax1 knockout alleviates AAV8-PCSK9-induced atherosclerosis. ( A ) Experimental scheme: 8-week-old Dax1 WT and Dax1 ΔMac mice (male and female) were injected with AAV8-PCSK9 via single tail vein and fed a Western diet for 12 weeks ( n = 10 per group). ( B ) Quantification of N

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Dax1 represses cholesterol transport in macrophages by interacting with LXR... Get access

in Nuclear receptor Dax1 promotes atherosclerosis by lipid transport inhibition and autophagy suppression in macrophages

Published: 22 April 2025

Figure 4 Dax1 represses cholesterol transport in macrophages by interacting with LXRα. ( A ) Volcano plot of differentially expressed genes in peritoneal macrophages from Dax1 WT and Dax1 ΔMac mice analysed by RNA sequencing ( n = 3 per group). Red arrows (pointing right) represent up-regulated genes, and

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Blood biomarkers in left-sided valvular heart disease Get access

Social factors, health policy, and environment: implications for cardiovascular disease across the globe

Acute right ventricular failure: pathophysiology, aetiology, assessment, and management Get access

Blood biomarkers of mitral regurgitation/mitral valve prolapse incidence, s... Get access

Biomarkers of structural valve deterioration. Apo-B, apolipoprotein-B; ApoB... Get access

Graphical Abstract

Environmental factors that have been linked to human behaviours and establi...

Fruit and vegetable servings per day (bars) and affordability (line) by cou...

Percentage availability of aspirin, β-blockers, angiotensin-converting enzy...

Proposed algorithm for the management of acute pulmonary embolism. CTPA, co... Get access

Nuclear receptor Dax1 promotes atherosclerosis by lipid transport inhibition and autophagy suppression in macrophages Get access

Structured Graphical Abstract

2′-Deoxycytidine enhances autophagy and reduces lipid accumulation by inhib... Get access

Graphical Abstract Get access

Blood biomarkers of aortic stenosis incidence, severity, progression, and c... Get access

Four-chamber apical right ventricular-focused view to ‘eyeball’ right ventr... Get access

Incident hyperkalaemia risk model in chronic kidney disease and diabetes: the FIDELITY programme

Derivation of risk score in placebo arm: distribution of the integer risk s...

Macrophage-specific Dax1 knockout alleviates AAV8-PCSK9-induced atheroscler... Get access

Dax1 represses cholesterol transport in macrophages by interacting with LXR... Get access

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