P166
Assessment of the relationship between novel proteins and cardiac cachexia in heart failure patients with reduced ejection fraction: adropin and irisin

Extract

Background: Cardiac cachexia is a serious and life-threatening complication of heart failure with reduced ejection fraction (HFrEF).

Purpose: The aims of the study were to evaluate adropin and irisin levels in cachectic and non-cachectic patients with HFrEF.

Methods: The clinical records of patients who were admitted to the outpatient cardiology clinic for HFrEF were screened. Cachectic patients were identified and assigned to the study group (n=44). HFrEF patients without weight loss were enrolled as the control group (n=42). The serum adropin and irisin levels of all the patients were measured.

Results: Body mass index (BMI), tricipital skinfold thickness (TST) and arm muscle area (AMA) were significantly lower in the cardiac cachexia group than the non-cachectic group. BNP, adropin and irisin levels were significantly higher in the cachectic group than non-cachectic group (for all p values <0.01). NYHA class and BNP levels were significantly positively correlated; however, BMI, AMA, TST and serum albumin were significantly inversely correlated with adropin and irisin levels. In the multivariate analysis, adropin (odds ratio [OR] 1.021, 95% CI: 1.004–1.038, p=0.017) was the only independent predictor of cachexia in patients with HFrEF.