P3338
Relation of myocardial performance index with measures of left ventricular cardiac function in heart failure patients - results from the MyoVasc study

Extract

Background: Myocardial performance index (MPI) is considered to be a reliable and highly reproducible echocardiographic parameter that aggregates information on left ventricular (LV) systolic and diastolic function.

Purpose: To investigate the relation between MPI and echocardiographic markers of systolic and diastolic function, and myocardial strain.

Methods: Data on the first 1,000 individuals with asymptomatic and symptomatic heart failure of the prospective, single-center cohort study MyoVasc were analysed. Clinical parameters and echocardiography were recorded in a highly standardized study setting. MPI was computed by the sum of isovolumetric contraction time and isovolumetric relaxation time divided by LV ejection time. LV ejection fraction (LVEF) was assessed by Simpson's method and diastolic function (E/E') according to the ratio of early diastolic velocity (E) and early diastolic tissue velocity (E') at the lateral mitral annulus in the apical 4-chamber view. The average of strain rate measurements from apical 2, 3, and 4-chamber view were used to calculate global longitudinal strain (GLS), whereas early diastolic strain rate (DsRE) was assessed at the time of early diastolic velocity. Individuals with atrial fibrillation during echocardiography and >5 missing segments in speckle-tracking analysis were excluded from analysis.