P5402
Evidence for an increased prevalence of aldosteronism among patients with coronary artery disease during the time of military conflict in Donbass region

Extract

Background/Introduction: During the last three-year period of the military conflict in Donbass region, there is a growing number of cases of coronary artery disease (CAD) caused by long-term war-associated stress. Plasma aldosterone level has been shown to be an independent predictor of cardiovascular morbidity and mortality in patient with CAD. It is well known that chronic stress can lead to increase in cortisol secretion, but its effect on aldosterone level is uncertain.

Purpose: The study aims to compare the prevalence of hyperaldosteronism among patients with CAD during peacetime and wartime in Donbass region and to assess the relationship between high aldosterone plasma level and the risk of major cardiovascular complications.

Methods: We collected the clinical data of 234 patients with stable CAD who were treated in cardiology department of the district hospital from January 1, 2015 to December 31, 2016, in the period of military conflict in war-zone of Donbass region. Clinical characteristics and plasma aldosterone level of this group were compared with those of 218 CAD patients comparable for age and gender treated in the same hospital in previous peacetime 2012–2013 years. After discharge from the hospital both groups were followed-up during 12-month period and the rate of major cardiovascular events was assessed.