Focus Issue on Imaging
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Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo
Optical coherence tomography (OCT) is increasingly used to understand coronary stent coverage and healing, and inform mechanisms and risks regarding stent thrombosis. Here we demonstrate, via in vivo NIRF fibrin molecular imaging agent and catheter technology, that stent coverage by OCT may actually reflect coverage by fibrin, a pro-thrombotic material, particularly at the edges of drug-eluting stents. Translationally, an MRI version of the NIRF fibrin-imaging agent has already been tested in Phase II trials, and near-infrared fluorophores such as indocyanine green are clinically approved. From a catheter standpoint, clinical intracoronary testing of a NIRF-OCT catheter is underway. Therefore, NIRF-OCT fibrin imaging has translational potential and could help assess the healing of implanted coronary stents in preclinical and clinical use.
Simultaneous dual-isotope solid-state detector SPECT for improved tracking of white blood cells in suspected endocarditis
Federico Caobelli1, Tim Wollenweber1, Udo Bavendiek2, Christian Kühn3, Christian Schütze4, Lilli Geworski4, James T. Thackeray1, Johann Bauersachs2, Axel Haverich3, and Frank M. Bengel1*
1Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany; 2Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; 3Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; and 4Department of Radiation Protection and Medical Physics, Hannover Medical School, Hannover, Germany
*Corresponding author. Klinik für Nuklearmedizin, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany. Tel: +49 511 532 2577, Fax: +49 511 532 3761, Email: email@example.com
See page 444 for the editorial comment on this article (doi:10.1093/eurheartj/ehw376)
Figure 4 Representative images of a patient with confirmed endocarditis affecting a mitral valve prosthesis. Planar white blood cell scans, conventional SPECT/CT and cadmium-zinc-telluride dual radioisotope images are shown. Only cadmium-zinc-telluride images show a discernible mild focal accumulation in the valve plane, adjacent to the mitral implant, consistent with focal endocarditis (yellow arrows).
See figure legend on page 440.
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