Focus Issue on Atherosclerosis
ISSUE @ A GLANCE
Novel therapeutic concepts
Coronary artery disease
NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice
Genetic deletion of the hydrogen peroxide producing NADPH oxidase 4 (Nox4), as shown in the present study, leads to endothelial dysfunction and increased atherosclerosis under pathological conditions. Consequently, endothelial activation of Nox4 may represent a promising novel strategy for preventing endothelial dysfunction and atherosclerosis and its severe clinical complications. This also suggests that in contrast to the deleterious effects of oxidative stress certain reactive oxygen species might mediate beneficial effects in the vessel wall.
We here conclusively demonstrate that the adipokine C1q/TNF-related protein (CTRP)-1 is associated in vivo with coronary artery disease, and has important pro-atherogenic effects in vitro and in vivo. Thus CTRP-1 is both a marker and a mediator, and may be a target for pharmacological interference.