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Issue Cover
Volume 37, Issue 22
7 June 2016
ISSN 0195-668X
EISSN 1522-9645

Focus Issue on Atherosclerosis



Current opinion


Novel therapeutic concepts

Brief Communication


Clinical Research

Coronary artery disease


Clinical Research


Basic science

Genetic deletion of the hydrogen peroxide producing NADPH oxidase 4 (Nox4), as shown in the present study, leads to endothelial dysfunction and increased atherosclerosis under pathological conditions. Consequently, endothelial activation of Nox4 may represent a promising novel strategy for preventing endothelial dysfunction and atherosclerosis and its severe clinical complications. This also suggests that in contrast to the deleterious effects of oxidative stress certain reactive oxygen species might mediate beneficial effects in the vessel wall.

We here conclusively demonstrate that the adipokine C1q/TNF-related protein (CTRP)-1 is associated in vivo with coronary artery disease, and has important pro-atherogenic effects in vitro and in vivo. Thus CTRP-1 is both a marker and a mediator, and may be a target for pharmacological interference.



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