This feature collection from the European Heart Journal showcases the latest clinical and translational published research from Asia. On a quarterly basis, we will update this repository with the latest research published in the journal with a corresponding author based in Asia. We invite you to read this collection of exemplary research.
FROM THE CONTINENT OF ASIA
Yong-Li Wang and others
European Heart Journal, ehae670, https://doi.org/10.1093/eurheartj/ehae670
Dendritic cells (DCs) are closely related to blood pressure (BP) regulation. Mineralocorticoid receptor (MR) is an important drug target for antihypertensive treatment. However, the role of DC MR in the pathogenesis of hypertension has not been fully elucidated. This study...
Seunghoon Cho and others
European Heart Journal, ehae790, https://doi.org/10.1093/eurheartj/ehae790
Artificial intelligence (AI) algorithms in 12-lead electrocardiogram (ECG) provides promising age prediction methods. This study investigated whether the discrepancy between ECG-derived AI-predicted age (AI-ECG age) and chronological age, termed electrocardiographic aging (ECG aging), is associated with atrial fibrillation (AF) risk.
Jia Huang and others
European Heart Journal, ehae711, https://doi.org/10.1093/eurheartj/ehae711
Although non-optimum ambient temperature is a major non-traditional risk factor for acute myocardial infarction, there is no prior knowledge on whether non-optimum ambient temperature could differentially affect myocardial infarction with obstructive coronary artery disease (MI-CAD) and myocardial infarction with non-obstructive...
Danbee Kang and others
European Heart Journal, Volume 46, Issue 1, 1 January 2025, Pages 84–95, https://doi.org/10.1093/eurheartj/ehae705
Despite the increasing popularity of electronic cigarettes (E-cigarettes), the prognostic impact of switching to E-cigarettes in smokers with coronary artery disease who have undergone percutaneous coronary intervention (PCI) remains unclear.
Steven H J Hageman and others
European Heart Journal, ehae609, https://doi.org/10.1093/eurheartj/ehae609
To improve upon the estimation of 10-year cardiovascular disease (CVD) event risk for individuals without prior CVD or diabetes mellitus in the Asia-Pacific region by systematic recalibration of the SCORE2 risk algorithm.
Artificial intelligence and digital tools for design and execution of cardiovascular clinical trials
Jiun-Ruey Hu and others
European Heart Journal, ehae794, https://doi.org/10.1093/eurheartj/ehae794
Recent advances have given rise to a spectrum of digital health technologies that have the potential to revolutionize the design and conduct of cardiovascular clinical trials. Advances in domain tasks such as automated diagnosis and classification, synthesis of high-volume data...
Yeshen Zhang and others
European Heart Journal, Volume 45, Issue 48, 21 December 2024, Pages 5156–5167, https://doi.org/10.1093/eurheartj/ehae706
Observational studies have highlighted that gestational diabetes mellitus is associated with a higher risk of cardiovascular diseases, but the causality remains unclear. Herein, the causality between genetic predisposition to gestational diabetes mellitus and the risk of cardiovascular diseases was investigated...
Peiwen Yang and others
European Heart Journal, ehae786, https://doi.org/10.1093/eurheartj/ehae786
Marfan syndrome (MFS) is a hereditary disorder primarily caused by mutations in the FBN1 gene. Its critical cardiovascular manifestation is thoracic aortic aneurysm (TAA), which poses life-threatening risks. Owing to the lack of effective pharmacological therapies, surgical intervention continues to...
Duanyang Xie and others
European Heart Journal, ehae699, https://doi.org/10.1093/eurheartj/ehae699
The cholinergic system is distributed in the nervous system, mediating electrical conduction through acetylcholine (ACh). This study aims to identify whether the heart possesses an intact endogenous cholinergic system and to explore its electrophysiological functions and relationship with arrhythmias in...
Shao-Wei Chen and others
European Heart Journal, ehae757, https://doi.org/10.1093/eurheartj/ehae757
This study aimed to evaluate the association between pregnancy and aortic complications and determine related maternal and neonatal outcomes.
Cheng Yu and others
European Heart Journal, Volume 46, Issue 3, 14 January 2025, Pages 288–304, https://doi.org/10.1093/eurheartj/ehae707
Vascular smooth muscle cell (VSMC) phenotype switching is a pathological hallmark in various cardiovascular diseases. N4-acetylcytidine (ac4C) catalyzed by N-acetyltransferase 10 (NAT10) is well conserved in the enzymatic modification of ribonucleic acid (RNA). NAT10-mediated ac4C acetylation is involved in various...
Yingli Lu and others
European Heart Journal, ehae887, https://doi.org/10.1093/eurheartj/ehae887
Atrial fibrillation (AF) has become the pre-dominant arrhythmia worldwide and is associated with high morbidity and mortality. Its pathogenesis is intricately linked to the deleterious impact of cardiovascular risk factors, emphasizing the pivotal imperative for early detection and mitigation strategies...
Hirotoshi Watanabe and others
European Heart Journal, ehae617, https://doi.org/10.1093/eurheartj/ehae617
There was no previous trial comparing aspirin monotherapy with a P2Y12 inhibitor monotherapy following short dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stents.
Atsushi Tanaka and others
European Heart Journal, ehae561, https://doi.org/10.1093/eurheartj/ehae561
The efficacy and safety of early sacubitril/valsartan (Sac/Val) initiation after acute heart failure (AHF) has not been demonstrated outside North America. The present study aimed to evaluate the effect of in-hospital Sac/Val therapy initiation after an AHF episode on N-terminal pro-B-type natriuretic peptide (NT-proBNP) level in Japanese patients.
He Huang and others
European Heart Journal, ehae532, https://doi.org/10.1093/eurheartj/ehae532
Despite advances in technology and techniques, the recurrence rate of persistent atrial fibrillation (AF) following catheter ablation remains high. The Shensong Yangxin (SSYX) capsule, a renowned traditional Chinese medicine formula, is used in the treatment of cardiac arrhythmias.
Ge Mang and others
European Heart Journal, Volume 45, Issue 37, 1 October 2024, Pages 3853–3867, https://doi.org/10.1093/eurheartj/ehae517
Heart failure (HF) is a leading cause of mortality worldwide and characterized by significant co-morbidities and dismal prognosis. Neutrophil extracellular traps (NETs) aggravate inflammation in various cardiovascular diseases; however, their function and mechanism of action in HF pathogenesis remain underexplored.
Jeehoon Kang and others
European Heart Journal, Volume 45, Issue 36, 21 September 2024, Pages 3721–3731, https://doi.org/10.1093/eurheartj/ehae462
Patients with high bleeding risk (HBR) undergoing percutaneous coronary intervention (PCI) are at increased risk of not only bleeding, but also ischaemic events. This study aimed to determine the long-term relative risk of ischaemic and bleeding events in HBR patients.
Takeshi Nishi and others
European Heart Journal, Volume 45, Issue 34, 7 September 2024, Pages 3181–3183, https://doi.org/10.1093/eurheartj/ehae460
Sudden cardiac arrest (SCA) represents a major public health challenge, accounting for a substantial proportion of cardiovascular deaths. Most SCAs are caused by coronary artery disease (CAD); however, the underlying pathophysiological mechanisms are not completely understood, particularly in patients without overt occlusive CAD.
Yuming Huang and others
European Heart Journal, Volume 45, Issue 37, 1 October 2024, Pages 3871–3885, https://doi.org/10.1093/eurheartj/ehae407
Valve interstitial cells (VICs) undergo a transition to intermediate state cells before ultimately transforming into the osteogenic cell population, which is a pivotal cellular process in calcific aortic valve disease (CAVD). Herein, this study successfully delineated the stages of VIC osteogenic transformation and elucidated a novel key regulatory role of lumican (LUM) in this process.
Ziang Li and others
European Heart Journal, ehae406, https://doi.org/10.1093/eurheartj/ehae406
Physical activity has proven effective in preventing atherosclerotic cardiovascular disease, but its role in preventing degenerative valvular heart disease (VHD) remains uncertain. This study aimed to explore the dose–response association between moderate to vigorous physical activity (MVPA) volume and the risk of degenerative VHD among middle-aged adults.
Xuesong Li and others
European Heart Journal, Volume 45, Issue 39, 14 October 2024, Pages 4219–4235, https://doi.org/10.1093/eurheartj/ehae379
Vascular smooth muscle cell (VSMC) senescence is crucial for the development of atherosclerosis, characterized by metabolic abnormalities. Tumour necrosis factor receptor-associated protein 1 (TRAP1), a metabolic regulator associated with ageing, might be implicated in atherosclerosis. As the role of TRAP1 in atherosclerosis remains elusive, this study aimed to examine the function of TRAP1 in VSMC senescence and atherosclerosis.
Young-Guk Ko and others
European Heart Journal, Volume 45, Issue 31, 14 August 2024, Pages 2839–2847, https://doi.org/10.1093/eurheartj/ehae372
Drug-coated balloons (DCBs) have demonstrated favourable outcomes following endovascular therapy for femoropopliteal artery (FPA) disease. However, uncertainty remains whether the use of intravascular ultrasound (IVUS) can improve the outcomes of DCBs.
You-Jung Choi and others
European Heart Journal, Volume 45, Issue 32, 21 August 2024, Pages 2983–2991, https://doi.org/10.1093/eurheartj/ehae335
Concerns about the safety of coronavirus disease 2019 (COVID-19) vaccines in patients with atrial fibrillation/flutter (AF/AFL) have arisen due to reports of thrombo-embolic events following COVID-19 vaccination in the general population. This study aimed to evaluate the risk of thrombo-embolic events after COVID-19 vaccination in patients with AF/AFL.
Taisuke Ishikawa and others
European Heart Journal, Volume 45, Issue 26, 7 July 2024, Pages 2320–2332, https://doi.org/10.1093/eurheartj/ehae251
Brugada syndrome (BrS) is an inherited arrhythmia with a higher disease prevalence and more lethal arrhythmic events in Asians than in Europeans. Genome-wide association studies (GWAS) have revealed its polygenic architecture mainly in European populations. The aim of this study was to identify novel BrS-associated loci and to compare allelic effects across ancestries.
Osung Kwon and others
European Heart Journal, Volume 45, Issue 25, 1 July 2024, Pages 2217–2231, https://doi.org/10.1093/eurheartj/ehae296
Platelet-fibrin clot strength (PFCS) is linked to major adverse cardiovascular event (MACE) risk. However, the association between PFCS and platelet reactivity and their prognostic implication remains uncertain in patients undergoing percutaneous coronary intervention (PCI).
Xingliang Zhou and others
European Heart Journal, Volume 45, Issue 25, 1 July 2024, Pages 2235–2250, https://doi.org/10.1093/eurheartj/ehae188
Patients with acute myeloid leukaemia (AML) suffer from severe myocardial injury during daunorubicin (DNR)-based chemotherapy and are at high risk of cardiac mortality. The crosstalk between tumour cells and cardiomyocytes might play an important role in chemotherapy-related cardiotoxicity, but this has yet to be demonstrated. This study aimed to identify its underlying mechanism and explore potential therapeutic targets.
Yuebin Lv and others
European Heart Journal, Volume 45, Issue 24, 21 June 2024, Pages 2145–2154, https://doi.org/10.1093/eurheartj/ehae206
Emerging evidence has raised an obesity paradox in observational studies of body mass index (BMI) and health among the oldest-old (aged ≥80 years), as an inverse relationship of BMI with mortality was reported. This study was to investigate the causal associations of BMI, waist circumference (WC), or both with mortality in the oldest-old people in China.
Yong-Moon Mark Park and others
European Heart Journal, Volume 45, Issue 21, 1 June 2024, Pages 1920–1933, https://doi.org/10.1093/eurheartj/ehae132
Longitudinal change in income is crucial in explaining cardiovascular health inequalities. However, there is limited evidence for cardiovascular disease (CVD) risk associated with income dynamics over time among individuals with type 2 diabetes (T2D).
Yong-Joon Lee and others
European Heart Journal, ehae249, https://doi.org/10.1093/eurheartj/ehae249
In patients with acute coronary syndrome (ACS), dual antiplatelet therapy (DAPT) with aspirin and a potent P2Y12 inhibitor is recommended for 12 months after drug-eluting stent (DES) implantation. Monotherapy with a potent P2Y12 inhibitor after short-term DAPT is an attractive option to better balance the risks of ischaemia and bleeding. Therefore, this study evaluated the efficacy and safety of ticagrelor monotherapy after short-term DAPT, especially in patients with ACS.
Mitsuyoshi Takahara and others
European Heart Journal, Volume 45, Issue 18, 7 May 2024, Pages 1634–1643, https://doi.org/10.1093/eurheartj/ehae207
Patients undergoing revascularization for lower extremity arterial disease (LEAD) may face a higher risk of mortality than those with coronary artery disease (CAD). This study aimed to characterize the difference in mortality risk between patients undergoing revascularization for LEAD and CAD and identify associated factors.
Kun Yang and others
European Heart Journal, Volume 45, Issue 18, 7 May 2024, Pages 1662–1680, https://doi.org/10.1093/eurheartj/ehae205
The Glu504Lys polymorphism in the aldehyde dehydrogenase 2 (ALDH2) gene is closely associated with myocardial ischaemia/reperfusion injury (I/RI). The effects of ALDH2 on neutrophil extracellular trap (NET) formation (i.e. NETosis) during I/RI remain unknown. This study aimed to investigate the role of ALDH2 in NETosis in the pathogenesis of myocardial I/RI.
Victor Chien-Chia Wu and others
European Heart Journal, Volume 45, Issue 17, 1 May 2024, Pages 1512–1520, https://doi.org/10.1093/eurheartj/ehae183
Studies on the impact of syphilis on the cardiovascular system in large populations are limited. This study investigated the effects of syphilis on cardiovascular outcomes.
Ying Sun and others
European Heart Journal, Volume 45, Issue 14, 7 April 2024, Pages 1281–1283, https://doi.org/10.1093/eurheartj/ehae130
Introduction Atrial fibrillation (AF) is the most prevalent arrhythmia managed in clinical practice especially in the aging population.1 Meanwhile, frailty is an age-related clinical condition featuring compromised physiological function of multiple systems.2 However, little is known regarding the association between...
Hae Suk Cheong and others
European Heart Journal, Volume 45, Issue 12, 21 March 2024, Pages 1072–1082, https://doi.org/10.1093/eurheartj/ehae020
High-risk human papillomavirus (HR-HPV) infection—a well-established risk factor for cervical cancer—has associations with cardiovascular disease (CVD). However, its relationship with CVD mortality remains uncertain. This study examined the associations between HR-HPV infection and CVD mortality.
Yudiyang Ma and others
European Heart Journal, Volume 45, Issue 12, 21 March 2024, Pages 1030–1039, https://doi.org/10.1093/eurheartj/ehad886
Air pollutants are important contributors to cardiovascular diseases, but associations between long-term exposure to air pollutants and the risk of abdominal aortic aneurysm (AAA) are still unknown.
Di He and others
European Heart Journal, Volume 45, Issue 12, 21 March 2024, Pages 1058–1068, https://doi.org/10.1093/eurheartj/ehad885
Previous studies found that frailty was an important risk factor for cardiovascular disease (CVD). However, previous studies only focused on baseline frailty status, not taking into consideration the changes in frailty status during follow-up. The aim of this study was...
Clonal haematopoiesis of indeterminate potential and atrial fibrillation: an east Asian cohort study
Hyo-Jeong Ahn and others
European Heart Journal, Volume 45, Issue 10, 7 March 2024, Pages 778–790, https://doi.org/10.1093/eurheartj/ehad869
Both clonal haematopoiesis of indeterminate potential (CHIP) and atrial fibrillation (AF) are age-related conditions. This study investigated the potential role of CHIP in the development and progression of AF.
