Differential willingness for genetic testing to target treatment in older Danish citizens

Abstract Background Studies from different countries have shown that population majorities are willing to accept genetic tests for treatment personalisation and that considerable proportions are ready to donate their data to research. However, it has also been shown that concerns, for example about data use and confidentiality or treatment rationing, are common. To enable a more targeted communication process with the public about personalized medicine, more knowledge is needed on views in different sub-populations. In the present study, a hypothetical scenario was used to investigate differential readiness to accept a genetic test for treatment targeting and to permit use of personal data for research. Methods A cross-sectional survey was conducted with 50-80-year-old Danish citizens (n = 6807) who were sampled to represent the Danish population in that age segment. Socio-demographic data were added from a national registry. Data were analyzed by multivariable logistic regression analysis. Results Preliminary results showed that a majority was willing to be tested (78.3%). Readiness was lower in women [OR = .67; CI = .59-.77] and those 70-80 [OR = .72; CI = 61-.86], while it was higher in those with better income [OR = 1.29; CI = 1.09-1.52]. Further, those less satisfied with their health, the obese and those with a perceived genetic vulnerability were more willing to be tested. Over 90% of those ready to be tested were also willing to permit use of their data for research. Rates were higher in men, older segments, those with higher income/education as well as those with current pain experience and those aware of a personal genetic vulnerability. Conclusions Findings indicate group differences in acceptance of a genetic test for personalisation of medicine and data use for research. Further research should investigate group-specific benefit perceptions versus concerns in population subgroups to inform implementation and enable targeted communication strategies. Key messages • Acceptance of genetic testing for personalisation of treatment as well as willingness to contribute data to research may differ between population subgroups. • Women and those with lower income are less willing to accept genetic testing for treatment personalisation and accept research use of data while health vulnerabilities increase acceptance.


Background:
Studies from different countries have shown that population majorities are willing to accept genetic tests for treatment personalisation and that considerable proportions are ready to donate their data to research. However, it has also been shown that concerns, for example about data use and confidentiality or treatment rationing, are common. To enable a more targeted communication process with the public about personalized medicine, more knowledge is needed on views in different sub-populations. In the present study, a hypothetical scenario was used to investigate differential readiness to accept a genetic test for treatment targeting and to permit use of personal data for research.

Methods:
A cross-sectional survey was conducted with 50-80-year-old Danish citizens (n = 6807) who were sampled to represent the Danish population in that age segment. Socio-demographic data were added from a national registry. Data were analyzed by multivariable logistic regression analysis.

Results:
Preliminary results showed that a majority was willing to be tested (78.3%). Readiness was lower in women [OR = .67; CI = .59-.77] and those 70-80 [OR = .72; CI = 61-.86], while it was higher in those with better income [OR = 1.29; CI = 1.09-1.52]. Further, those less satisfied with their health, the obese and those with a perceived genetic vulnerability were more willing to be tested. Over 90% of those ready to be tested were also willing to permit use of their data for research. Rates were higher in men, older segments, those with higher income/ education as well as those with current pain experience and those aware of a personal genetic vulnerability.

Conclusions:
Findings indicate group differences in acceptance of a genetic test for personalisation of medicine and data use for research. Further research should investigate group-specific benefit perceptions versus concerns in population subgroups to inform implementation and enable targeted communication strategies.

Key messages:
Acceptance of genetic testing for personalisation of treatment as well as willingness to contribute data to research may differ between population subgroups. Women and those with lower income are less willing to accept genetic testing for treatment personalisation and accept research use of data while health vulnerabilities increase acceptance.

DY Public health monitoring, reporting and foresight
Abstract citation ID: ckac131.555 The influence of overweight and obesity in the oral health of a sample of portuguese adults

Background:
Overweight and obesity may lead to different problems in various body systems and in the oral cavity. Dental caries and periodontal disease have been related with overweight. The aim of this study was to assess how overweight and obesity have impact on the lifestyle, oral habits and oral pathologies.

Methods:
We conducted an observational cross-sectional study where we applied a questionnaire to 140 individuals from Lisbon and Viseu, Portugal., which 70 had a normal Body Mass Index (BMI) (control group) and 70 had an excessive BMI. We also made an oral observation in each individual to record the permanent teeth decayed, missing and filled index (DMFT), the Community Periodontal Index and the oral hygiene status.

Results:
From the final sample, 30% of the subjects with overweight brushed their teeth once a day or less, while the majority (62.9%) of the control group brushed twice a day. In the oral examination, 70% had calculus, while in the control group only 22.5% presented calcified plaque. The DMFT was higher among the obesity group in comparison with the control group. Regarding periodontal disease, the participants with overweight need more dental intervention (81.4%) in contrast with the control group (14%).

Conclusions:
Most overweight and obese individuals present precarious oral hygiene habits, higher prevalence of dental caries, and worse periods of periodontal health. They are not aware of the repercussions of the association between their cariogenic diet, oral health and overweight.