Articles with Impact

The state of the art in scholarly peer review.

Contrary to a prevailing paradigm, some animals do not host nor rely on a microbiome.

Persistent identifiers enable trusted connections between researchers, their publications and their organizations that ultimately build trust in research, reducing the potential for errors and saving researchers time and hassle.

Discourse for scientists and space administrators on how and why to elevate microorganisms as essential components of future colonization strategies of our solar system.

In the search for novel topical skin therapies, we have examined skin-derived bacteriocins, produced by microbes which have evolved in such a way as to outcompete pathogens, and successfully colonise the skin environment.

NanoSIMS imaging shows that metabolically-active cells of Geobactersulfurreducens were co-located with an iron(III)-(oxyhydr)oxide surface, consistent with this bacterium requiring direct contact with an extracellular electron acceptor.

Large scale epidemiological survey of 21 tick-borne viruses in 18 135 Ixodes ricinus allowed through the development of a new high-throughput tool based on microfluidic real-time PCR.

Combination of virulent bacteriophages (bacterial viruses) and antibiotics has the potential to eliminate the biofilms.

This review aims to raise awareness among mycobacterial researchers of the many global resources available, including culture collections distributing mycobacterial biomaterials as well as other valuable resources such as databases and computational/bioinformatics tools.

Retrospective on the work of Bernard Dujon.

Saccharomyces pastorianus is a hybrid yeast that has been domesticated since the 16th century. The review presents the slough of lager yeast research under the influence of genome science.

Streamlined CRISPR-Cas9 protocols for genome editing in Saccharomyces cerevisiae executable by virtually any yeast molecular geneticist.

Antibiotics in general, and specifically those administered during early childhood, have major effects on the microbiome composition that persist weeks to months after antibiotic exposure.

Aroma compounds provide attractiveness and variety to alcoholic beverages. We discuss the molecular biology of a major subset of beer aroma volatiles, fruity and floral compounds, originating from raw materials (malt and hops), or formed by yeast during fermentation. 

Removing plasmids from bacteria in different ecosystems could be an important aspect of fighting antimicrobial resistance.

The impact of climate change on vector-borne diseases has implications for public health and calls for monitoring climatic precursors of outbreaks as well as integrated surveillance of cases and vectors.

Strategies to improve the ability of plants to fix atmospheric dinitrogen are discussed, with a special focus on recent advances in biochemistry, synthetic biology and plant biotechnology.

Type III secretion systems: complex devices for the delivery of bacterial effector proteins into eukaryotic host cells.

The authors find that airborne bacteria in southwest Greenland are aerosolized mostly from permafrost soils and that these bacteria include types with a high potential to be active either in the atmosphere or after settling down to new environments.

This study demonstrated that dairy manure applications to soil significantly increase the abundance of clinically relevant ARGs when compared to control and inorganic fertilized plots.

This review describes insights in the diversity and functions of the fish bacterial communities elucidated with next-generation sequencing and discusses the potential of the microbes to mitigate (re-)emerging diseases in aquaculture.

The authors focus on the diverse effectors that Mycobacterium tuberculosis uses in its multi-pronged effort to subvert the innate immune responses of macrophages.

Akkermansia muciniphila might be considered as one of the ideal new probiotics used in the management of type 2 diabetes mellitus.

This article discusses the molecular evolution and ecology of clostridial neurotoxins in light of recently discovered homologs of these toxins in non-clostridial genomes.

This article describes a novel laboratory evolution approach to select for mutations that enable decreased fermentation times in second-generation bioethanol production processes with the yeast Saccharomyces cerevisiae.

The international Synthetic Yeast Genome (Sc2.0) project is discovering the dots that connect basic eukaryotic biology, biodesign, bioengineering and biomanufacturing with a budding bioeconomy of the future.

The availability of various genetic mutant libraries combined with a high degree of mechanistic conservation relevant to aging make yeast a powerful screening platform for the identification and mechanistic study of novel anti-aging compounds.

This review defines which ecological and environmental factors are important for the development of antibiotic resistance in human pathogens, and suggests some possible mitigation strategies to delay and reduce increased resistance.

Bacterial–fungal interactions are cornerstones of numerous processes that impact ecosystem functions, animal and plant physiology, and industrial activities.

Microbial association networks can integrate biological information and may even represent complex ecosystem properties, but their application and interpretation requires more context from network theory, ecology and microbial physiology.

Scaling up industrial microbial processes is a costly, high-stakes endeavor that can be executed successfully if approached properly.

The review presents recent advances and applications of three main areas of biotechnology, namely industrial, agricultural and marine biotechnology, respectively, known by the colors white, green and blue.

This MiniReview discusses the recent developments and the future outlook in the microbial ecology and enzymology of ammonia oxidation, a core process in the global nitrogen cycle

Current issues and standards with positive and negative controls in microbiome research are discussed.

In this review, we highlight the most-wanted methane- and ammonia-oxidizing spookmicrobes discovered in the past quarter century.

We review important contemporary studies related to high-alpine microbial ecology associated with the impact of climate change.

The global emergency due to the novel type of coronavirus (2019-nCoV) appeared in China highlights the high zoonotic potential of coronaviruses and the need of international collaboration to block viral spread.

The interaction between two common wound pathogens increases colonisation and virulence during early infection.

Mycobacterium tuberculosis uses cholesterol and fatty acids together to cause disease, we are just now beginning to understand how this process occurs.

Yeast in vaccine development.

This review gives an overview of mitochondrial metabolism and function with a focus on Saccharomyces cerevisiae, highlighting the role of the yeast in studying mitochondrial systems biology.

The yeast cell size, intracellular morphology and population structure vary in course of the glucose unlimited anaerobic batch growth in regard to the growth temperature.

This review explores the area of ARB research, summarises the current state of ARB development – including modifying enzyme inhibitors, membrane permeabilisers and efflux pump inhibitors – and offers a perspective on the future direction of the field.

Bacterial–fungal interactions are cornerstones of numerous processes that impact ecosystem functions, animal and plant physiology, and industrial activities.

The review describes the complex dynamics underlying the interactions between Mycobacterium tuberculosis and the human host cell with an emphasis on the cell biology approaches and potential challenges to study these processes.