Close
Advanced Search

Abstract

Protection conferred by a cell-free preparation from a haemolytic Moraxella bovis isolate, UQV 148NF, was compared to an equivalent fraction from a non-haemolytic M. bovis isolate, Gordon 26L3, and to a recombinant DNA-derived pili vaccine. Three groups of ten calves were vaccinated twice with one of the three preparations and, together with ten non-vaccinated calves, challenged with virulent M. bovis isolate Dal 2d. Compared to the control group, significant protection was observed in the group receiving the pili vaccine and the group receiving the preparation from haemolytic isolate, UQV 148NF.

Moraxella bovis, Haemolysin, Vaccine, Infectious bovine keratoconjunctivitis

References

1
Thrift
F.A.
Overfield
J.R.
(
1974
)
Impact of Pinkeye (Infectious Bovine Keratoconjunctivitis) on weaning and postweaning performance of hereford calves
J. Anim. Sci.
 ,
38
,
1179
–
1184
.
Google Scholar
CrossRef
Search ADS
PubMed
 
2
Slatter
D.H.
Edwards
M.E.
Hawkins
C.D.
Wilcox
G.E.
(
1982
)
A national survey of the clinical features, treatment and importance of Infectious Bovine keratoconjunctivitis
Aust. Vet. J.
 ,
59
,
69
–
72
.
Google Scholar
CrossRef
Search ADS
PubMed
 
3
Pugh
G.W.
Hughes
D.E.
(
1968
)
Experimental Bovine Infectious Keratoconjunctivitis caused by sunlamp irradiation and Moraxella bovis infection: correlation of haemolytic ability and pathogenicity
Am. J. Vet. Res.
 ,
29
,
835
–
839
.
Google Scholar
PubMed
 
4
Moore
L.J.
Rutter
J.M.
(
1987
)
Antigenic analysis of fimbrial proteins from Moraxella bovis
J. Clin. Microbiol.
 ,
25
,
2063
–
2070
.
Google Scholar
PubMed
 
5
Rogers
D.G.
Cheville
N.F.
Pugh
G.W.
(
1987
)
Pathogenesis of corneal lesions caused by Moraxella bovis in gnotobiotic calves
Vet. Pathol.
 ,
24
,
287
–
295
.
Google Scholar
CrossRef
Search ADS
PubMed
 
6
Beard
M.K.K.M.
(
1991
)
Ph.D Thesis, University of Sydney
,
7
Lepper
A.W.D.
(
1988
)
Vaccination against Infectious Bovine Keratoconjunctivitis: protective efficacy and antibody response induced by pili of homologous and heterologous strains of Moraxella bovis
Aust. Vet. J.
 ,
65
,
310
–
316
.
Google Scholar
CrossRef
Search ADS
PubMed
 
8
Lepper
A.W.D.
Moore
L.J.
Atwell
J.L.
Tennent
J.M.
(
1992
)
The protective efficacy of pili from different strains of Moraxella bovis within the same serogroup against Infectious Bovine Keratoconjunctivitis
Vet. Microbiol.
 ,
32
,
177
–
187
.
Google Scholar
CrossRef
Search ADS
PubMed
 
9
Moore
L.J.
Lepper
A.W.D.
(
1991
)
A unified typing scheme for Moraxella bovis
Vet. Microbiol.
 ,
29
,
75
–
83
.
Google Scholar
CrossRef
Search ADS
PubMed
 
10
Schwartzkoff
C.L.
Egerton
J.R.
Stewart
D.J.
Lehrbach
P.R.
Elleman
T.C.
Hoyne
P.A.
(
1993
)
The effects of antigenic competition on the efficacy of multivalent footrot vaccines
Aust. Vet. J.
 ,
70
,
123
–
129
.
Google Scholar
CrossRef
Search ADS
PubMed
 
11
Raadsma
H.W.
O'Meara
T.J.
Egerton
J.R.
Lehrbach
P.R.
Schwartzkoff
C.L.
(
1994
)
Protective antibody titres and antigenic competition in multivalent Dichelobacter nodosus fimbrial vaccines using characterised rDNA antigens
Vet. Immunol. Immunopathol.
 ,
40
,
253
–
274
.
Google Scholar
CrossRef
Search ADS
PubMed
 
12
Ostle
A.G.
Rosenbusch
R.F.
(
1985
)
Immunogenicity of Moraxella bovis haemolysin
Am. J. Vet. Res.
 ,
46
,
1011
–
1014
.
Google Scholar
PubMed
 
13
Elleman
T.C.
Hoyne
P.A.
Lepper
A.W.D.
(
1990
)
Characterisation of the pilin gene of Moraxella bovis Dalton 2d and expression of pili from M. bovis in Pseudomonas aeruginosa
Infect. Immun.
 ,
58
,
1678
–
1684
.
Google Scholar
PubMed
 
14
Lepper
A.W.D.
Elleman
T.C.
Hoyne
P.A.
Lehrbach
P.R.
Atwell
J.L.
Schwartzkoff
C.L.
Egerton
J.R.
Tennent
J.M.
(
1993
)
A Moraxella bovis pili vaccine produced by recombinant DNA technology for the prevention of Infectious Bovine Keratoconjunctivitis
Vet. Microbiol.
 ,
36
,
175
–
183
.
Google Scholar
CrossRef
Search ADS
PubMed
 
© 1994 Federation of European Microbiological Societies
Topic:
Issue Section:
Articles
Download all figures