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Georg A. Sprenger, Alfried Vogler, Joseph W. Lengeler; Selection of auxotrophic and carbohydrate-negative mutants in penicillin-resistant Klebsiella pneumoniae by nalidixic acid treatment, FEMS Microbiology Letters, Volume 37, Issue 3, 1 December 1986, Pages 299–304, https://doi.org/10.1111/j.1574-6968.1986.tb01812.x
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Summary
The bactericidal antibiotic nalidixic acid can be used to select in cultures of Klebsiella pneumoniae and other penicillin-resistant enteric bacteria any auxotrophic and carbohydrate-negative mutant. Nalidixic acid treatment is superior to penicillin or d-cycloserine treatment, since no cross-feeding by lysed cells is possible, and it is simple to handle.
Klebsiella pneumoniae, nalidixic acid, mutant selection, anxotrophic mutant, carbohydrate-negative mutant
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