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Journal Article
Vibrio cholerae: Understanding a persistent pathogen in Sub-Saharan Africa and the East Mediterranean Region
Pathogens and Disease, Volume 83, 2025, ftaf004, https://doi.org/10.1093/femspd/ftaf004
Published: 26 March 2025
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Africa and Asia cholera cases: 1 January 2025 to 20 January 2025 (European ...
Published: 26 March 2025
Figure 1.
Africa and Asia cholera cases: 1 January 2025 to 20 January 2025 (European Centre for Disease Prevention and Control 2025 ).
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Overview of gene expression amongst samples and results from differential g...
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Isolate-specific rat brain transcriptional responses to rat lungworm (Angiostrongylus cantonensis)
Published: 19 February 2025
Figure 1.
Overview of gene expression amongst samples and results from differential gene expression analysis of Wistar rats experimentally infected with A. cantonensis isolates, SYD.1 and SYD.2, and uninfected controls. (A) Boxplot of gene read distribution for all rat brain samples [as log 2 (FKPM + 1); N
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Comparison of L1 shedding and total adult worm burden of rats infected with...
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Isolate-specific rat brain transcriptional responses to rat lungworm (Angiostrongylus cantonensis)
Published: 19 February 2025
Figure 5.
Comparison of L1 shedding and total adult worm burden of rats infected with A. cantonensis isolates SYD.1 or SYD.2. (A) Shedding of first-stage larvae (L1s) in faeces of rats infected with A. cantonensis isolates SYD.1 or SYD.2. L1s/g faeces of four rats (two infected with SYD.1 and another two
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Direct comparison of gene expression profiles between rats infected with ...
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Isolate-specific rat brain transcriptional responses to rat lungworm (Angiostrongylus cantonensis)
Published: 19 February 2025
Figure 4.
Direct comparison of gene expression profiles between rats infected with A. cantonensis isolates SYD.1 and SYD.2 and subsequent DEG functional analyses. (A) PCA plot illustrating sample FKPM distribution for SYD.1 (orange) and SYD.2 (green) groups. (B) Volcano plot depicting DEGs identified by com
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Overview of the host response to infection with A. cantonensis in ...
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Isolate-specific rat brain transcriptional responses to rat lungworm (Angiostrongylus cantonensis)
Published: 19 February 2025
Figure 6.
Overview of the host response to infection with A. cantonensis in definitive (rat) hosts extrapolated from RNA transcriptomic data from rats infected with the SYD.1 and SYD.2 isolates ( cox 1 haplotype SYD.1 and Ac13, respectively). The response from a non-permissive canine host (indicated with th
Journal Article
Isolate-specific rat brain transcriptional responses to rat lungworm (Angiostrongylus cantonensis)
Pathogens and Disease, Volume 83, 2025, ftaf003, https://doi.org/10.1093/femspd/ftaf003
Published: 19 February 2025
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Overview of differential gene expression analysis comparing rats infected w...
in
Isolate-specific rat brain transcriptional responses to rat lungworm (Angiostrongylus cantonensis)
Published: 19 February 2025
Figure 2.
Overview of differential gene expression analysis comparing rats infected with A. cantonensis isolates SYD.1 and SYD.2 to uninfected rats (mock controls). Plots (A–C) are from the SYD.1 vs. mock control comparison, and plots (D–F) are from the SYD.2 vs. mock control comparison. (A) Plot from PCA o
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Subsequent functional enrichment analysis of the DEGs (N = 227) id...
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Isolate-specific rat brain transcriptional responses to rat lungworm (Angiostrongylus cantonensis)
Published: 19 February 2025
Figure 3.
Subsequent functional enrichment analysis of the DEGs ( N = 227) identified between rats infected with A. cantonensis SYD.2 isolate (=Ac13 cox 1 haplotype) and uninfected controls. (A) Bubble plot depicting the top 10 significant KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways. Significa
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Laminarin inhibits chlamydial entry and infectivity in cervical epithelial ...
Published: 30 January 2025
Figure 3.
Laminarin inhibits chlamydial entry and infectivity in cervical epithelial cells. (a) Chlamydial EB titer assays from EB exposed to H 2 O or Lam prior to HeLa culture infection. (b and c) EB binding assays. Replicate aliquots of Ch. trachomatis EB were preincubated with H 2 O, Lam, or Lam-Ant befo
Journal Article
EDITOR'S CHOICE
Dectin-1 stimulating β-glucans inhibit Chlamydia infections both in vitro and in vivo
Pathogens and Disease, Volume 83, 2025, ftaf002, https://doi.org/10.1093/femspd/ftaf002
Published: 30 January 2025
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Laminarin inhibits Ch. muridarum infection in vitro and ...
Published: 30 January 2025
Figure 4.
Laminarin inhibits Ch. muridarum infection in vitro and in vivo . (a-b) EB titer assays. (a) Ch. muridarum EB (Cm) were incubated with H 2 O or Lam for 1 h prior to infection. (b) HeLa cultures were infected with Cm inoculum + H 2 O or Lam during infection. Data shown are means ± SEM ( n = 6
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EBs bind to specific Ca. albicans surface proteins. (a−c) Ca. ...
Published: 30 January 2025
Figure 1.
EBs bind to specific Ca. albicans surface proteins. (a−c) Ca. albicans (Ca) yeast cultures were exposed to H 2 O or Pronase A, washed, and then incubated with Ch. trachomatis EB (CtE) for 1 h. EBs bound to yeast were collected by centrifugation and processed for immunofluorescent labeling (a a
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CaBGs inhibit chlamydial infection in cervical cells. (a) Chlamydial EB tit...
Published: 30 January 2025
Figure 2.
CaBGs inhibit chlamydial infection in cervical cells. (a) Chlamydial EB titer assays from EB exposed to H 2 O or CaBG prior to HeLa culture infection. (b-c) HeLa cultures were infected with Ch. trachomatis inoculum + H 2 O or CaBG. At 48 hpi, the cultures were harvested for immunostaining (b) or E
Journal Article
Typing of feces-derived Candida albicans strains using a novel seven-locus microsatellite panel reveals associations with yeast phenotype in individuals with inflammatory bowel disease
Pathogens and Disease, Volume 83, 2025, ftaf001, https://doi.org/10.1093/femspd/ftaf001
Published: 10 January 2025
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Analysis of genetic diversity of feces-derived C. albicans strains...
Published: 10 January 2025
Figure 1.
Analysis of genetic diversity of feces-derived C. albicans strains through MSNs and principle component analysis. N = 29 individuals ( n = 14 CD, n = 5 UC, n = 9 HV) were included in this analysis, resulting in n = 257 C. albicans strains. (A) MSN was determined based on seven microsatell
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Enzymatic activity of feces-derived C. albicans strains reveals no...
Published: 10 January 2025
Figure 2.
Enzymatic activity of feces-derived C. albicans strains reveals no differentially active enzymes. (A–E) Enzyme activity was based in triplicate for one strain per individual. Each data point represents mean activity of a strain as determined in triplicate. (A) Proteinase activity. (B) Phospholipas
Journal Article
Characterization of beta2-adrenergic receptor knockout mouse model during Chlamydia muridarum genital infection
Pathogens and Disease, Volume 82, 2024, ftae029, https://doi.org/10.1093/femspd/ftae029
Published: 11 December 2024
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Production of cytokines by T cells of stressed and non-stressed beta2-adren...
Published: 11 December 2024
Figure 5.
Production of cytokines by T cells of stressed and non-stressed beta2-adrenergic receptor knockout (β-AR) and WT mice during C. muridarum genital infection. (A) Interferongamma (IFN-γ), (B) IL-4, (C) IL-10 by CD4+ T cells, and (D) IFN-γ by CD8 + T cells. Each point value represents the means ± SD
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Comparison of CD4 T cell phenotypes in cold-stressed β-AR KO and WT mice du...
Published: 11 December 2024
Figure 7A.
Comparison of CD4 T cell phenotypes in cold-stressed β-AR KO and WT mice during C. muridarum genital mice. The expression of effector (CD44 + CD62L−), memory (CD44 + CD62L+), and naïve (CD44− CD62L+) CD4+ T cell surface isolated from different treatment groups is shown in percentiles on the right
