Abstract

Heparan sulphate binding to Helicobacter pylori at pH 4 to 5 was inhibited with various sulphated polysaccharides (heparin and chondroitin sulphates, fucoidan, carrageenans and some others), but not by carboxylated or nonsulphated compounds. Heparin binding proteins are exposed on the cell surface.

References

1
Baba
M.
Pauwels
R.
Balzarini
J.
Arnout
J.
Desmyter
J.
De Clercq
E.
(
1988
)
Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro
.
Proc. Natl. Acad. Sci. USA
 
85
,
6132
6136
.
2
Butcher
B.A.
Sklar
L.A.
Seamer
L.C.
Glew
R.H.
(
1992
)
Heparin enhances the interaction of infective Leishmania donovani promastigotes with mouse peritoneal macrophages. A fluorescence flow cytometric analysis
.
J. Immunol.
 
148
,
2879
2886
.
3
Choi
S.H.
Stinson
M.W.
(
1989
)
Purification of a Streptococcus mutans protein that binds to heart tissue and glycosaminoglycans
.
Infect. Immun.
 
57
,
3834
3840
.
4
Frevert
U.
Sinnis
P.
Cerami
C.
Shreffler
W.
Takacs
B.
Nussenzweig
V.
(
1993
)
Malaria circumsporozoite protein binds to heparan sulphate proteoglycans associated with the surface membrane of hepatocytes
.
J. Exp. Med.
 
177
,
1287
1298
.
5
Kulane
A.
Ekre
H.-P.
Perlman
P.
Rombo
L.
Wahlgren
M.
Wahlin
B.
(
1992
)
Effect of different fractions of heparin on Plasmodium falciparum merozoite invasion of red blood cells in vitro
.
Am. J. Trop. Med. Hyg.
 
48
,
589
594
.
6
Lycke
E.
Johansson
M.
Svennerholm
B.
Lindahl
U.
(
1991
)
Binding of Herpes simplex virus to cellular heparan sulphate, an initial step in the adsorption process
.
J. Gen. Virology
 
72
,
1131
1137
.
7
Mc Clure
M.O.
Moore
J.P.
Blanc
D.F.
Scotting
P.
Cook
G.M.W.
Keynes
R.J.
Weber
J.N.
Davies
D.
Weiss
R.A.
(
1992
)
Investigations into the mechanism by which sulphated polysaccharides inhibit HIV infection in vitro
.
AIDS Res. Human Retroviruses
 
8
,
19
26
.
8
Ortega-Barria
E.
Pereira
M.E.A.
(
1992
)
Entry of Trypanosoma cruzi into eukariotic cells
.
Infect. Agents Dis.
 
1
,
136
145
.
9
Pancake
S.J.
Holt
G.D.
Mellouk
S.
Hoffman
S.L.
(
1992
)
Malaria sporozoites and circumsporozoite proteins bind specifically to sulphated glycoconjugates
.
J. Cell Biol.
 
117
,
1351
1357
.
10
Stephens
R.S.
(
1992
)
Molecular mimicry and Chlamydia -host cell interactions
. In:
Proceedings of the European Society for Chlamydia research
  .
Stockholm
Sept. 2–5
(
Mårdh
P.A.
La Placa
M.
Ward
M.
, Eds.).
11
Trybala
E.
Svennerholm
B.
Bergström
T.
Olofsson
S.
Jeansson
S.
Goodman
J.L.
(
1993
)
Herpes simplex virus type 1 induced haemagglutination: glycoprotein C mediates virus binding to erythrocyte surface heparan sulphate
.
J. Virol.
 
67
,
1278
1285
.
12
Vaudaux
P.
Avramoglou
T.
Letourneur
D.
Lew
D.P.
Jozefonvicz
J.
(
1992
)
Inhibition by heparin and derivatized dextrans of Staphylococcus aureus adhesion to fibronectin-coated biomaterials
.
J. Biomater. Sci. Polymer Edn.
 
4
,
89
97
.
13
Liang
O.D.
Ascencio
F.
Fransson
L.-Å.
Wadström
T.
(
1992
)
Binding of heparan sulphate to Staphylococcus aureus
.
Infect. Immun.
 
60
,
899
906
.
14
Ascencio
F.
Fransson
L.-Å.
Wadström
T.
(
1993
)
Affinity of the gastric pathogen Helicobacter pylori for the N-sulphated glycosaminoglycan heparan sulphate
.
J. Med. Microbiol.
 
38
,
240
244
.
15
Fransson
L.-Å.
Havsmark
B.
Silverberg
I.
(
1990
)
A method for the sequence analysis of dermatan sulphate
.
Biochem. J.
 
269
,
381
388
.
16
Lelwala-Guruge
J.
Ljungh
Å.
Wadström
T.
(
1992
)
Haemagglutination patterns of Helicobacter pylori
.
APMIS
 
100
,
908
913
.
17
Soltesz
V.
Schalen
C.
Mårdh
P.A.
(
1988
)
New selective medium for Campylobacter pylori
. In:
Proceedings of the Fourth International Workshop on Campylobacter Infection
  (
Kaijser
B.
Falsen
E.
, Eds.), pp.
433
436
.
Gothenburg, Sweden
.
18
Czinn
S.
Carr
H.
Sheffler
L.
Aronoff
S.
(
1989
)
Serum IgG antibody to the outer membrane proteins of Campylobacter pylori in children with gastroduodenal disease
.
J. Infect. Dis.
 
159
,
586
589
.
19
Laemmli
U.K.
(
1970
)
Cleavage of structural proteins during the assembly of the head of bacteriophage
.
Nature
 
227
,
680
685
.
20
Fransson
L.-Å.
(
1987
)
Structure and functions of cell associated proteoglycans: FIBS 12
  .
406
411
,
Elsevier
,
The Netherlands
.
21
Menozzi
F.D.
Mutombo
R.
Renauld
G.
Gantiez
C.
Hannah
J.H.
Leininger
E.
Brennan
M.J.
Locht
C.
(
1994
)
Heparin-inhibitable lectin activity of the filamentous hemagglutinin adhesin of Bordetella pertussis
.
Infect. Immun.
 
62
,
769
778
.
22
Menozzi
F.D.
Gantiez
C.
Locht
C.
(
1991
)
Interaction of the Bordetella pertussis filamentous hemagglutinin with heparin
.
FEMS Microbiol. Lett.
 
78
,
59
64
.
23
Westerlund
B.
Korhonen
T.K.
(
1993
)
Bacterial proteins binding to the mammalian extracellular matrix
.
Mol. Microbiol.
 
9
,
687
694
.
24
Trust
T.J.
Doig
P.
Emödy
L.
Kienle
Z.
Wadström
T.
O'Toole
P.
(
1991
)
High-affinity binding of the basement membrane proteins collagen type IV and laminin to the gastric pathogen Helicobacter pylori
.
Infect. Immun.
 
59
,
4398
4404
.
25
Valkonen
K.H.
Ringnér
M.
Ljungh
Å.
Wadström
T.
(
1993
)
High-affinity binding of laminin by Helicobacter pylori : Evidence for a lectin-like interaction
.
FEMS Immun. Med. Microbiol.
 
7
,
29
38
.
26
Borén
T.
Falk
P.
Roth
K.A.
Larson
G.
Normark
S.
(
1993
)
Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens
.
Science
 
262
,
1892
1895
.
27
Chen
J.C.-R.
Stephens
R.S.
(
1994
)
Trachoma and LGV biovars of Chlamydia trachomatis share the same glycosaminoglycan dependent mechanism for infection of eukaryotic cells
.
Mol. Microbiol.
 
11
,
501
507
.
28
Ortega-Barria
E.
Pereira
M.E.A.
(
1991
)
A novel T. cruzi heparin-binding protein promotes fibroblast adhesion and penetration of engineered bacteria and Trypanosomes into mammalian cells
.
Cell
 
67
,
411
421
.
29
Blaser
M.J.
(
1992
)
Pathogenesis of Helicobacter pylori -induced inflammation: a “slow” bacterial infection
.
Eur. J. Gastroenterol. Hepatol.
 
4
, (
Suppl 1
),
17
19
.
30
Blaser
M.J.
(
1992
)
Hypothesis on the pathogenesis and natural history of Helicobacter pylori -induced inflammation
.
Gastroenterol.
 
102
,
720
727
.