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antimicrobial resistant biofilms

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Journal Article

Toxin–antitoxin systems and their role in disseminating and maintaining antimicrobial resistance

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Qiu E. Yang and Timothy R. Walsh
FEMS Microbiology Reviews, Volume 41, Issue 3, May 2017, Pages 343–353, https://doi.org/10.1093/femsre/fux006
Published: 16 March 2017
... that biofilms are closely linked to antibiotic resistance and that a biofilm can form slimy layers that surround the bacteria and act as a barrier to antimicrobial agents, decreasing the penetration of antibiotics to the bacterium's surface (Davies 2003 ). When cells are embedded in a biofilm, their MIC has...
Journal Article

Viscoelasticity of biofilms and their recalcitrance to mechanical and chemical challenges

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Brandon W. Peterson and others
FEMS Microbiology Reviews, Volume 39, Issue 2, March 2015, Pages 234–245, https://doi.org/10.1093/femsre/fuu008
Published: 25 February 2015
... process yielding relaxation to an original shape over time. (B) Structure and composition govern the resistance of biofilms against chemical challenge in combination with altered phenotypes that are intrinsically more resistant to antimicrobials. (C) Composition and structure are jointly reflected...
Journal Article

Survival proteomes: the emerging proteotype of antimicrobial resistance

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Amber J. Park and others
FEMS Microbiology Reviews, Volume 40, Issue 3, May 2016, Pages 323–342, https://doi.org/10.1093/femsre/fuv051
Published: 19 January 2016
... spectrometry studies that examine the proteomes of antimicrobial-resistant bacteria. 22 12 2015 16 09 2015 © FEMS 2016. All rights reserved. For permissions, please e-mail: [email protected] 2016 Antimicrobial resistance is one of the greatest challenges...
Journal Article

Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria

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Clayton W. Hall and Thien-Fah Mah
FEMS Microbiology Reviews, Volume 41, Issue 3, May 2017, Pages 276–301, https://doi.org/10.1093/femsre/fux010
Published: 25 March 2017
... to withstand antimicrobial therapy. biofilm bacteria antibiotic antimicrobial resistance tolerance Biofilms are microbial communities that adhere to biotic or abiotic surfaces, and the cells within a biofilm are encased in self-produced matrix. Biofilms are medically important because they have been...
Journal Article

Multi-species biofilms: living with friendly neighbors

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Sivan Elias and Ehud Banin
FEMS Microbiology Reviews, Volume 36, Issue 5, September 2012, Pages 990–1004, https://doi.org/10.1111/j.1574-6976.2012.00325.x
Published: 01 September 2012
... beneficial interactions, which include for example, changes in extracellular polymeric substances (EPS) composition, biofilm resistance to antimicrobial agents and environmental stress conditions, improved utilization of nutritional resources and the spatial distribution within the mixed biofilm community...
Journal Article

Impact of nanosystems in Staphylococcus aureus biofilms treatment

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Rita M Pinto and others
FEMS Microbiology Reviews, Volume 43, Issue 6, November 2019, Pages 622–641, https://doi.org/10.1093/femsre/fuz021
Published: 17 August 2019
... approach. Besides bacterial resistance, other drawbacks are also associated to the treatment against bacterial biofilms. Antimicrobial drugs are commonly administered through the oral route, with a poor bioavailability and efficacy of drugs (Pinto et al. 2017 ). Additionally, the systemic...
Journal Article

Role of the extracellular matrix in Candida biofilm antifungal resistance

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Justin Massey and others
FEMS Microbiology Reviews, Volume 47, Issue 6, November 2023, fuad059, https://doi.org/10.1093/femsre/fuad059
Published: 10 October 2023
... : e00680 – 18 . Harriott MM , Noverr MC . Candida albicans and Staphylococcus aureus form polymicrobial biofilms: effects on antimicrobial resistance . Antimicrob Agents Chemother . 2009 ; 53 : 3914 – 22 . Harriott MM , Noverr MC . Ability...
Journal Article
EDITOR'S CHOICE

Protozoan predation as a driver of diversity and virulence in bacterial biofilms

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M Mozammel Hoque and others
FEMS Microbiology Reviews, Volume 47, Issue 4, July 2023, fuad040, https://doi.org/10.1093/femsre/fuad040
Published: 17 July 2023
... and resistance to antimicrobial agents (Personnic et al. 2019 , 2021 ). T. pyriformis predation of A. hydrophila results in SCV with increased capacity to form biofilms (Liu et al. 2018 ). Predation of L. pneumophila by H. vermiformis in a mixed species potable water...
Journal Article

What’s in a name? Characteristics of clinical biofilms

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Mads Lichtenberg and others
FEMS Microbiology Reviews, Volume 47, Issue 5, September 2023, fuad050, https://doi.org/10.1093/femsre/fuad050
Published: 01 September 2023
... precisely characterized new functional metabolites that regulate biofilm formation in Escherichia coli . Anal Chim Acta . 2021 ; 1145 : 26 – 36 . Gupta K , Liao J , Petrova OE et al. Elevated levels of the second messenger c-di-GMP contribute to antimicrobial resistance...
Journal Article

Emergent heterogeneous microenvironments in biofilms: substratum surface heterogeneity and bacterial adhesion force-sensing

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Yijin Ren and others
FEMS Microbiology Reviews, Volume 42, Issue 3, May 2018, Pages 259–272, https://doi.org/10.1093/femsre/fuy001
Published: 09 January 2018
...Yijin Ren; Can Wang; Zhi Chen; Elaine Allan; Henny C van der Mei; Henk J Busscher The biofilm phenotype of bacteria is distinguished from the planktonic state by emergent properties (‘localized gradients, sorption and retention, cooperation and competition, tolerance and resistance’: see Text Box...
Journal Article

The sociobiology of biofilms

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Carey D. Nadell and others
FEMS Microbiology Reviews, Volume 33, Issue 1, January 2009, Pages 206–224, https://doi.org/10.1111/j.1574-6976.2008.00150.x
Published: 03 December 2008
..., but it appears to promote surface attachment and provide structural support; mutants that cannot produce EPS are often deficient in biofilm formation ( Davies, 1993 ; Danese, 2000 ; Hammer & Bassler, 2003 ; Kearns, 2005 ). EPS may also afford protection from external threats, such as antimicrobial...
Journal Article

The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosis

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Rhastin A D Castro and others
FEMS Microbiology Reviews, Volume 45, Issue 4, July 2021, fuaa071, https://doi.org/10.1093/femsre/fuaa071
Published: 15 December 2020
... Graphical Abstract Figure. Heteroresistance is an important stepping-stone to how an initially monoclonal and drug-susceptible population of Mycobacterium tuberculosis becomes fully resistant to a given antimicrobial during the course of an infection, and this review discusses how bacterial...
Journal Article

Structural analysis of novel drug targets for mitigation of Pseudomonas aeruginosa biofilms

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Moumita Ghosh and others
FEMS Microbiology Reviews, Volume 47, Issue 5, September 2023, fuad054, https://doi.org/10.1093/femsre/fuad054
Published: 28 September 2023
..., the diagnosis and treatment of infections associated with biofilms remain a considerable hurdle in healthcare, with treatment strategies for such infections still in their infancy. Biofilm development is also a primary factor contributing to the emergence of antimicrobial resistance. Long, aggressive treatment...
Journal Article

Gut biofilms: Bacteroides as model symbionts to study biofilm formation by intestinal anaerobes

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Nathalie Béchon and Jean-Marc Ghigo
FEMS Microbiology Reviews, Volume 46, Issue 2, March 2022, fuab054, https://doi.org/10.1093/femsre/fuab054
Published: 25 November 2021
... antimicrobials properties (Urdaneta and Casadesús 2017 ). Bile has been shown to induce biofilm formation in a wide range of gut bacteria including symbionts such as B. thetaiotaomicron, Lactobacillus and Bifidobacterium and the pathogens C. difficile, B. fragilis, Listeria monocytogenes...
Journal Article

Multi-species biofilms: how to avoid unfriendly neighbors

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Olaya Rendueles and Jean-Marc Ghigo
FEMS Microbiology Reviews, Volume 36, Issue 5, September 2012, Pages 972–989, https://doi.org/10.1111/j.1574-6976.2012.00328.x
Published: 01 September 2012
... have often focused on antagonisms impairing fitness of bacterial competitors via, for instance, the production of toxins, scavenger molecules, and antimicrobials. However, biofilm formation is a complex process involving multiple adhesion and dispersion events which, from initial surface contact to tri...
Journal Article

Do phenothiazines possess antimicrobial and efflux inhibitory properties?

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Elizabeth M Grimsey and Laura J V Piddock
FEMS Microbiology Reviews, Volume 43, Issue 6, November 2019, Pages 577–590, https://doi.org/10.1093/femsre/fuz017
Published: 19 June 2019
... Graphical Abstract Figure. The use of phenothiazines as antibiotic adjuvants could be invaluable in the fight against antimicrobial resistance. 25 01 2019 12 06 2019 © The Author(s) 2019. Published by Oxford University Press on behalf of FEMS. 2019 This article...
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Schematic overview of the major antimicrobial resistance and tolerance mech...

Schematic overview of the major antimicrobial resistance and tolerance mech...

Published: 25 March 2017
Figure 1. Schematic overview of the major antimicrobial resistance and tolerance mechanisms employed by bacterial biofilms. Biofilm cells (yellow rectangles) are embedded in a mushroom-shaped matrix (shown in green). The biofilm is attached to a surface (grey rectangle), which can be biotic or abiotic
Journal Article

Perspectives for clinical use of engineered human host defense antimicrobial peptides

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María Eugenia Pachón-Ibáñez and others
FEMS Microbiology Reviews, Volume 41, Issue 3, May 2017, Pages 323–342, https://doi.org/10.1093/femsre/fux012
Published: 18 May 2017
... the emergence of resistance, often observed with other antimicrobial therapies. More than 2700 HDPs have been described so far from the six Kingdoms (bacteria, archaea, protists, fungi, plants and animals; http://aps.unmc.edu/AP/main.php ) (Wang, Li and Wang 2016 ). They can be classified in four groups: (i...
Journal Article

Potential targets for next generation antimicrobial glycoconjugate vaccines

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Francesca Micoli and others
FEMS Microbiology Reviews, Volume 42, Issue 3, May 2018, Pages 388–423, https://doi.org/10.1093/femsre/fuy011
Published: 14 March 2018
... the development of efficacious novel well-defined vaccines is also discussed. carbohydrates glycoconjugates vaccines glycoengineering antimicrobial resistance Surface carbohydrates, particularly capsular polysaccharides (CPS), have been proven optimal targets for bacterial vaccines development...
Journal Article

The role of bacterial transport systems in the removal of host antimicrobial peptides in Gram-negative bacteria

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Jessica M A Blair and others
FEMS Microbiology Reviews, Volume 46, Issue 6, November 2022, fuac032, https://doi.org/10.1093/femsre/fuac032
Published: 24 June 2022
... Graphical Abstract Figure. This review describes how Gram-negative bacteria use efflux pumps as a mechanism of resistance against antimicrobial peptides (AMPs), including the efflux of AMPs to the extracellular space and the internalization of AMPs to the cytoplasm followed by proteolytic digestion. We...