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DNA damage response
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RFC/sliding clamp-dependent regulation of various DNA damage response pathw...
Published: 24 June 2015
Figure 3.
RFC/sliding clamp-dependent regulation of various DNA damage response pathways. Various RFC complexes affect PCNA and 9–1–1 complex in different ways. Each RFC complex has distinct ability to load/unload of sliding clamps and their modified forms and/or to stimulate particular modification
Journal Article
DNA damage-induced gene expression in Saccharomyces cerevisiae
FEMS Microbiology Reviews, Volume 32, Issue 6, November 2008, Pages 908–926, https://doi.org/10.1111/j.1574-6976.2008.00126.x
Published: 10 October 2008
...: [email protected] 15 2 2008 27 5 2008 28 5 2008 Saccharomyces cerevisiae DNA damage transcriptional regulation SOS response cell-cycle checkpoint signal transduction DNA is the carrier of genetic information in most organisms. Any damage to the molecular structure of DNA has...
Journal Article
DNA damage bypass pathways and their effect on mutagenesis in yeast
FEMS Microbiology Reviews, Volume 45, Issue 1, January 2021, fuaa038, https://doi.org/10.1093/femsre/fuaa038
Published: 25 August 2020
... by Rad5 PCNA-EF DDT Error-free DNA damage bypass controlled by PCNA ssDNA Single-stranded DNA CPD Cyclobutane pyrimidine dimer UBM Ubiquitin-binding domain DDR DNA damage response DC DNA damage checkpoint RC Replication checkpoint The genomes of all organisms...
Journal Article
Aeons of distress: an evolutionary perspective on the bacterial SOS response
FEMS Microbiology Reviews, Volume 31, Issue 6, November 2007, Pages 637–656, https://doi.org/10.1111/j.1574-6976.2007.00082.x
Published: 01 November 2007
... initially that the SOS response might be a universal adaptation of bacteria to DNA damage. Indeed, later work in other bacterial species has mainly confirmed this idea. Functional LexA homologues regulating genes involved in DNA repair have been characterized for instance in the Actinobacterium...
Journal Article
DNA repair in Mycobacterium tuberculosis revisited
FEMS Microbiology Reviews, Volume 33, Issue 3, May 2009, Pages 471–487, https://doi.org/10.1111/j.1574-6976.2009.00170.x
Published: 01 May 2009
... in mycobacteria ( Della et al., 2004 ). Does NHEJ promote mycobacterial survival during latency or reactivation from latency? RecA and the DNA damage response The existence of a recA-independent mechanism of gene regulation, which is important for DNA repair in M. tuberculosis ( Rand et...
Journal Article
DNA repair in the archaea—an emerging picture
FEMS Microbiology Reviews, Volume 42, Issue 4, July 2018, Pages 514–526, https://doi.org/10.1093/femsre/fuy020
Published: 05 May 2018
... deamination, oxidation or methylation, is the most common and unavoidable type of DNA damage. Therefore, it is perhaps not surprising that the DNA repair pathway responsible for detection and correction of these lesions, BER, is ubiquitous and fundamentally conserved across all domains of life. The canonical...
Journal Article
DNA replication fidelity in Escherichia coli: a multi-DNA polymerase affair
FEMS Microbiology Reviews, Volume 36, Issue 6, November 2012, Pages 1105–1121, https://doi.org/10.1111/j.1574-6976.2012.00338.x
Published: 01 November 2012
... ). There are 30–50 molecules of Pol II per cell, which is several times more than the number of Pol III HE molecules (Qui & Goodman, 1997 ). The level of Pol II increases about sevenfold following SOS induction (global response to DNA damage) (Bonner et al., 1990 ; Iwasaki et al., 1990...
Journal Article
The endoplasmic reticulum unfolded protein response – homeostasis, cell death and evolution in virus infections
FEMS Microbiology Reviews, Volume 45, Issue 5, September 2021, fuab016, https://doi.org/10.1093/femsre/fuab016
Published: 25 March 2021
... DENV Dengue virus DDR DNA damage response DnaK Bacterial chaperone Hsp70 EDEM ERAD enhancing α-mannosidase-like proteins eIF2α Eukaryotic translation initiation factor 2 subunit1 ERAD ER-associated degradation ERdj4 ER-localised J-protein 4 ERSE ER-stress...
Journal Article
The contribution of DNA repair pathways to genome editing and evolution in filamentous pathogens
FEMS Microbiology Reviews, Volume 46, Issue 6, November 2022, fuac035, https://doi.org/10.1093/femsre/fuac035
Published: 09 July 2022
... to the different types of physiochemical DNA damage, generally referred to as the DNA-damage response (Jackson and Bartek 2009 ). This review focuses on one specific type of DNA damage, termed DNA double-strand breaks (DSBs), in which the covalent phosphodiester bond between adjacent sugar atoms of DNA...
Journal Article
The Roles of Bacterial DNA Double-Strand Break Repair Proteins in Chromosomal DNA Replication
FEMS Microbiology Reviews, Volume 44, Issue 3, May 2020, Pages 351–368, https://doi.org/10.1093/femsre/fuaa009
Published: 14 April 2020
.... 2007 ; Costes et al. 2010 ). Interestingly, the DNA damage response also determines the coupling between sporulation and DNA replication, sporulation being inhibited in a recA-dependent manner following DNA damage (Ireton and Grossman 1992 ). Additionally, RecA, RecO, AddAB...
Journal Article
Biology of telomeres: lessons from budding yeast
FEMS Microbiology Reviews, Volume 38, Issue 2, March 2014, Pages 144–171, https://doi.org/10.1111/1574-6976.12054
Published: 01 March 2014
... stability aging cancer DNA replication DNA damage response The genome of most eukaryotic organisms is divided into linear chromosomes. Each chromosomal end is protected by a special nucleoprotein structure called telomere. Telomeres play central roles in maintaining the stability of the genome...
Journal Article
Genetic instability in budding and fission yeast—sources and mechanisms
FEMS Microbiology Reviews, Volume 39, Issue 6, November 2015, Pages 917–967, https://doi.org/10.1093/femsre/fuv028
Published: 24 June 2015
...RFC/sliding clamp-dependent regulation of various DNA damage response pathways. Various RFC complexes affect PCNA and 9–1–1 complex in different ways. Each RFC complex has distinct ability to load/unload of sliding clamps and their modified forms and/or to stimulate particular modification...
Journal Article
DNA base repair – recognition and initiation of catalysis
FEMS Microbiology Reviews, Volume 33, Issue 6, November 2009, Pages 1044–1078, https://doi.org/10.1111/j.1574-6976.2009.00188.x
Published: 01 November 2009
... 12 06 2009 © 2009 Federation of European Microbiological Societies. 2009 Abstract Endogenous DNA damage induced by hydrolysis, reactive oxygen species and alkylation modifies DNA bases and the structure of the DNA duplex. Numerous mechanisms have evolved to protect cells from these deleterious...
Journal Article
DNA interstrand cross-link repair in Saccharomyces cerevisiae
FEMS Microbiology Reviews, Volume 31, Issue 2, March 2007, Pages 109–133, https://doi.org/10.1111/j.1574-6976.2006.00046.x
Published: 01 March 2007
... and export, all these factors have to be considered to gain a complete insight into the cytotoxic effects of ICL-forming agents. In addition, there is emerging evidence that naturally occurring cross-linking agents might be responsible for some of the DNA damage burden of certain cells. For example...
Journal Article
Escherichia coli DNA replication: the old model organism still holds many surprises
FEMS Microbiology Reviews, Volume 48, Issue 4, July 2024, fuae018, https://doi.org/10.1093/femsre/fuae018
Published: 09 July 2024
...), is responsible for the lion’s share of DNA replication. Pol III HE is a complex of 10 distinct proteins that can be organized into three subassemblies: the polymerase core (Pol III), the sliding clamp, and the clamp loader complex (CLC; Fig. 1A ) (McHenry 2011 , Yao and O’Donnell 2016 ). An important integral...
Journal Article
Pulses and delays, anticipation and memory: seeing bacterial stress responses from a single-cell perspective
FEMS Microbiology Reviews, Volume 44, Issue 5, September 2020, Pages 565–571, https://doi.org/10.1093/femsre/fuaa022
Published: 18 June 2020
... damage response in a series of pulses, whose number scaled with the UV dose in E. coli (Friedman et al. 2005 ). In contrast, continuous treatments with chemical DNA damaging agents do not cause pulses but stable SOS gene expression in E. coli (Henrikus et al. 2018...
Journal Article
Microbial antigenic variation mediated by homologous DNA recombination
FEMS Microbiology Reviews, Volume 36, Issue 5, September 2012, Pages 917–948, https://doi.org/10.1111/j.1574-6976.2011.00321.x
Published: 01 September 2012
... to the identification of RecXEc as a negative regulator of RecAEc during the SOS response (Stohl et al., 2003 ). A similar activity was subsequently described for RecXNg, which acts on RecANg to limit the extent of RecA polymerization onto single-stranded DNA...
Journal Article
The Escherichia coli heat shock response and bacteriophage λ development
FEMS Microbiology Reviews, Volume 17, Issue 1-2, August 1995, Pages 159–169, https://doi.org/10.1111/j.1574-6976.1995.tb00198.x
Published: 01 August 1995
.... Their biological roles include a direct involvement in A DNA replication and morphogenesis, the
protection of proteins from aggregation, the disaggregation of various protein aggregates, the manipulation of protein
structure and function, as well as the autoregulation of the heat shock response. The evolution...
Journal Article
Learning from the master: targets and functions of the CtrA response regulator in Brucella abortus and other alpha-proteobacteria
FEMS Microbiology Reviews, Volume 42, Issue 4, July 2018, Pages 500–513, https://doi.org/10.1093/femsre/fuy019
Published: 03 May 2018
... CtrA-controlled functions, for instance motility and DNA repair, are proposed to be more ancestral. Altogether, these analyses provide an interesting example of the plasticity of a regulation network, subject to the constraints of inherent imperatives such as cell division and the adaptations...
Journal Article
Archaeal DNA replication and repair: new genetic, biophysical and molecular tools for discovering and characterizing enzymes, pathways and mechanisms
FEMS Microbiology Reviews, Volume 42, Issue 4, July 2018, Pages 477–488, https://doi.org/10.1093/femsre/fuy017
Published: 18 April 2018
...), genetics (green) and capillary electrophoresis (blue). As cells grow and divide, they are continuously exposed to DNA-damaging agents that arise endogenously by cellular metabolism, or from external environmental factors. The exposure to DNA-damaging agents leads to the formation of a variety of DNA...
