pathogen genome evolution

...) The impact of DNA repair on genome evolution. We pay special attention to filamentous pathogens in section four, as previous observations on genome variation and evolution have detailed biased genome evolution, and we suggest this may be driven in part by variation in DNA repair, which could influence...

... of this organism with humans, variability is observed at multiple time frames and spatial scales so that H. pylori represents a good model to comprehend the diversification of bacterial pathogens. Helicobacter pylori genomics evolution restriction-modification systems methylome transcriptome...

... et al., 2009 ). However, this paradigm of reductive genome evolution does not hold for microorganisms living in amoebal hosts. These pathogens rather exhibit an opposite trend in genome evolution when compared with those associated to lice ( Fig. 3 ). Indeed, amoebal intracellular parasites...

.... Alternatively, genomic variations in reticulate bacteria, such as many intestinal and plant cell-associated Proteobacteria, will depend not only on these processes, but also on their genetic interactions with other bacterial strains. Common pathogenic domains necessary for the invasion and survival...

... of a non-host-restricted lineage, which served as a valuable reference of the ancestral state to infer genome evolution (Clayton et al. 2012 ; Oakeson et al. 2014 ). This particular lineage, Sodalis praecaptivus, was described as an opportunistic human pathogen, isolated from...

... of strain W14 [12] . Sample sequencing of the W14 genome was achieved by sequencing approximately 2000 random DNA clones. These sequences were then compared against existing protein and nucleotide databases to look for genes known to be involved in symbiosis or pathogenicity in other systems...

... scabies , is also available, though currently not annotated ( ftp://ftp.sanger.ac.uk/pub/pathogens/ssc/Ssc.dbs ). This makes it possible to use comparative genomics to attempt to trace the evolution of Streptomyces development, and in doing this, perhaps to deepen our understanding...

... . Baba T Bae T Schneewind O Takeuchi F Hiramatsu K ( 2008 ) Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands . J Bacteriol 190 : 300...

... are independent of clonality and provide another view on S. aureus evolution. Genome sequencing of nine S. aureus strains has helped identify a number of virulence factors, but the key determinants for infection are still unknown. Comparison of commensal and pathogenic strains shows...

... bacteria. horizontal gene transfer genomic island evolution pathogenicity biodegradation Genomes of bacterial species can evolve through a variety of processes including mutations, rearrangements or horizontal gene transfer. Information gathered over the past few years from a rapidly increasing number...

... in the generation of antigenic variation, an interesting mechanism whereby some bacterial pathogens are able to avoid the host immune system. In this review, we analyze examples of bacterial gene conversion (some of them spawned from the current genomic revolution), as well as the molecular models that explain gene...

...-T3SSs have been discovered (often more than one per genome) in a highly diverse group of clinically and/or economically important animal and human pathogens ( Table 1 and Fig. 1 ). Many, if not most, of these have been discovered through genome sequencing. Some have already been linked to virulence...

... of bacterial genomic islands that can be transferable by conjugation, their intra- and intercellular mobility, and the mechanisms involved in their evolution and plasticity. conjugative transposon mobilizable transposon pathogenicity island mobilization in trans mobilization in cis site...

... transfers (HGTs) in prokaryotes disguises their evolutionary relationships and have led to questioning of the Darwinian model of evolution for prokaryotes. These inferences are critically examined in the light of comparative genome analysis, characteristic synapomorphies, phylogenetic trees and Darwin's...

... an advantage in their ecological niches. lignin degradation fungi bacteria ecology evolution Wood-decaying fungal Basidiomycota ecologically represent white and brown rot, litter-decomposing, plant-pathogenic and ectomycorrhizal (ECM) fungi, although over 90% of all known wood-rotting species belong...

.... 2012 ; Jones et al. 2013 ; Vanaerschot et al. 2013 ). A trans-kingdom tendency for increased pathogen virulence (hypervirulence) is beginning to emerge and be noted. The genetic flexibility of pathogens, most of which have haploid genomes, permits rapid evolutionary changes, which can...

..., for example during trophallaxis, the bee is exposed to DWV via the gut, an organ shaped by evolution to provide protection from environmental pathogens (Mikonranta et al. 2014 ). Altering the transmission route leads to significant changes in the virus population, including a large increase...

... pathogens) is valuable in screening for new antibiotics and identifying bacterial factors necessary to cause disease. 19 10 2022 07 03 2023 10 03 2023 28 03 2023 © The Author(s) 2023. Published by Oxford University Press on behalf of FEMS. 2023 This is an Open...

... with the combination of nuclear and organelle genomes, such as mitochondrial genomes, in the zygote. This allows recombination events to accelerate evolution. However, a common process in eukaryotic sex is uniparental mitochondrial inheritance, a process that results in the asexual inheritance of the organelle genome...

... investigations into the evolution of transcriptional patterns of bacterial pathogens during infection, starting from the colonization step to host damage. Such a comprehensive analysis was even called the ‘holy grail’ of gene expression measurement ( Boyce et al., 2004a ). Therefore, in the last few...