Collection
Nobel Laureates Collection
To name a few: McClintock’s research on maize genetics and cytogenetics (1929 ff.); Luria and Delbruck’s pioneering work on bacterial mutation to resistance to phage infection (1943); Lewis’ invention of the cis-trans test for position effect (1945), which led to his prize-winning research on the Drosophila Bithorax Complex mutants; Lederberg’s discovery of genetic recombination in E. coli (1947); Hershey and Rotman’s and Luria and Dulbecco’s discovery of genetic recombination in phage (1949); Snell’s analysis of histocompatibility genes in mouse (1951); Arber’s analysis of host specificity in E. coli (1965); Hartwell’s screens for cell cycle genes in budding yeast (1973); Brenner and Sulston’s establishment of C. elegans as a genetic model (1974). Not all of the papers in the collection led to the Nobel Prize. Some of the papers will come as a surprise: Did you know that Jacques Monod, of E. coli lac operon fame, carried out ovary transplants in Drosophila in 1937? Did you know that Oliver Smithies, of site-directed mutagenesis fame, studied inherited variations of serum proteins in cattle (1958)? This collection is testimony to the high esteem that GENETICS has had, and continues to have, for the worldwide community of geneticists. As GENETICS continues to publish important work in genetics and genomics it is always worth remembering that, to paraphrase Isaac Newton, if we see further now, it is by standing on the shoulders of giants.
Hermann J Muller
GENETICS, Volume 3, Issue 5, 1 September 1918, Pages 422–499, https://doi.org/10.1093/genetics/3.5.422
In numerous breeding experiments there is positive evidence that the factors concerned undergo no sensible fluctuation, nor sensible contamination during segregation. But, unfortunately for a clear and simple proof or disproof of the generality of these principles…H J Muller
GENETICS, Volume 13, Issue 4, 1 July 1928, Pages 279–357, https://doi.org/10.1093/genetics/13.4.279
Biologists are in general agreed that the basic problems of organic evolution are concerned largely with the nature. the causation, and the modes of transmission of heritable variations…
Barbara McClintock
GENETICS, Volume 14, Issue 2, 1 March 1929, Pages 180–222, https://doi.org/10.1093/genetics/14.2.180
During the course of investigation on the chromosome number and behavior of different genetic strains of maize a triploid individual appeared in an otherwise diploid culture…A H Sturtevant, G W Beadle
GENETICS, Volume 21, Issue 5, 1 September 1936, Pages 554–604, https://doi.org/10.1093/genetics/21.5.554
Studies of chromosome aberrations such as polyploidy and trans- S locations have contributed much to the understanding of the meiotic behavior of chromosomes. One of the commonest types of structural difference in chromosomes…
Jacques Monod, D F Poulson
GENETICS, Volume 22, Issue 2, 1 March 1937, Pages 257–263, https://doi.org/10.1093/genetics/22.2.257
The transplantation of ovaries in Drosophila was realized for the first T time by EPHRUSSI and BEADLE (1935b), using the technique which they had devised and applied with such success to the transplantation of the eye discs and other anlagen...
Barbara McClintock
GENETICS, Volume 23, Issue 4, 1 July 1938, Pages 315–376, https://doi.org/10.1093/genetics/23.4.315
It is the purpose of this paper to describe the method by which viable I tissues, homozygous deficient for a known region of a chromosome, ray be produced in maize. The chromosomal region involved includes the locus of the gene Bm 1 in chromosome V…Barbara McClintock
GENETICS, Volume 26, Issue 2, 8 March 1941, Pages 234–282, https://doi.org/10.1093/genetics/26.2.234
If chromosomes are broken by various means, the broken ends I appear to be adhesive and tend to fuse with one another 2-by-2. This has been abundantly illustrated in the studies of chromosomal aberrations induced by X-ray treatment…
S E Luria, M Delbrück
GENETICS, Volume 28, Issue 6, 20 November 1943, Pages 491–511, https://doi.org/10.1093/genetics/28.6.491
When a pure bacterial culture is. attacked by a bacterial virus, the culture will clear after a few hours due to destruction of the sensitive ceIls by the virus. However, after further incubation for a few hours, or sometimes days, the culture will often become turbid again…
E B Lewis
GENETICS, Volume 30, Issue 2, 15 March 1945, Pages 137–166, https://doi.org/10.1093/genetics/30.2.137
In drosophila melanogaster it has been established that the action of at least some genes is affected by their position in the chromosomes. Critical evidence for this phenomenon of position effect has been given by STURTEVANT (1g25), DUBININ and SIDOROW (1g35), and PANSHIN (1935)…
Joshua Lederberg
GENETICS, Volume 32, Issue 5, 1 September 1947, Pages 505–525, https://doi.org/10.1093/genetics/32.5.505
The occurrence of factor recombination in the bacterium, Escherichia coli, T has been described in previous reports (LEDERBERG and TATUM, 1946 b, c, TATUM and LEDERBERG, 1947). In an attempt to elucidate further the genetic structure of this organism, these studies have been extended to crosses involving several characters…S E Luria, R Dulbecco
GENETICS, Volume 34, Issue 2, 1 March 1949, Pages 93–125, https://doi.org/10.1093/genetics/34.2.93
The potentialities of bacteriophage genetics have been revealed by the T discovery of genetic recombinations among related phage particles infecting the same bacterial cell (DELBRUCK and BAILEY 1946). The complexities of these genetic systems have been further illustrated by the work of HERSHEY and ROTMA…
George D Snell, George F Higgins
GENETICS, Volume 36, Issue 3, 1 May 1951, Pages 306–310, https://doi.org/10.1093/genetics/36.3.306
Previously published data (GORER 1942; GORER, LYMAN and SNELL P 1948) have shown that alleles at the histocompatibility-2 locus in the mouse have a dual effect, determining a blood group antigen and also susceptibility or resistance to certain transplantable tumors…
Joshua Lederberg, Luigi L Cavalli, Esther M Lederberg
GENETICS, Volume 37, Issue 6, 1 November 1952, Pages 720–730, https://doi.org/10.1093/genetics/37.6.720
Genetic recombination in bacteria was first successfully studied in strain G K-12 of Esclzericlzia coli (TATUM and LEDERBERG 1947; LEDERBERG 1951). Since the nutritional mutants used in the crosses were derived directly from this strain under clonal propagation, their conipatibility implied a homothallic or self-compatible sexual system…
O Smithies, C G Hickman
GENETICS, Volume 43, Issue 3, 1 May 1958, Pages 374–385, https://doi.org/10.1093/genetics/43.3.374
The recent demonstration of permanent differences in the serum proteins (SMITHIES and WALKER 1955, 1956) suggested the value of a similar investigation of the serum proteins of cattle. We have consequently examined serum samples from over 140 dairy cattle…
Eugene W Nester, Marion Schafer, Joshua Lederberg
GENETICS, Volume 48, Issue 4, 1 April 1963, Pages 529-551, https://doi.org/10.1093/genetics/48.4.529
Studies on the structure of the segmental genetic map in Bacillus subtilis have revealed a close linkage relationship between genes of indole and histidine biosynthesis ( EPHRATI-ELIZUR, SINIVASAN and ZAMENHOF 196 1 ; NESTER and LEDERBERG 1961). More recently, ANAGNOSTOPOULOS and CRAWFORD (1961) showed that…
Werner Arber, M L Morse
GENETICS, Volume 51, Issue 1, 8 January 1965, Pages 137–148, https://doi.org/10.1093/genetics/51.1.137
Bacterial host cells endow the DNA of bacteriophage h and that of the transducing phage hdg with host specificity (ARBER and DUSSOIX 1962; ARBER 1964). This label on the DNA plays an important role in phage infection. In the absence of the required host specificity...Dan L Lindsley, L Sandler, Bruce S Baker, Adelaide T C Carpenter, R E Denell, et al.
GENETICS, Volume 71, Issue 1, 1 May 1972, Pages 157–184, https://doi.org/10.1093/genetics/71.1.157
The following is an account of a procedure designed to examine the effects, in Theterozygous condition, of a set of non-overlapping autosomal deletions that cover the entire autosomal complement of Drosophila as well as the effects of the duplication corresponding to each deletion…
Leland H Hartwell, Robert K Mortimer, Joseph Culotti, Marilyn Culotti
GENETICS, Volume 74, Issue 2, 1 June 1973, Pages 267–286, https://doi.org/10.1093/genetics/74.2.267
Saccharomyces cerevisiae is an appropriate organism for the genetic dissection of the mitotic cell division cycle. First, this organism undergoes the same sequence of events during cell division in both the haplophase and diplophase…
S Brenner
GENETICS, Volume 77, Issue 1, 1 May 1974, Pages 71–94, https://doi.org/10.1093/genetics/77.1.71
How genes might specify the complex structures found in higher organisms is a major unsolved problem in biology. Many of the molecular mechanisms involved in gene expression in prokaryotic microorganisms have already been found to exist in a relatively unmodified form in eukaryotic cells…
J E Sulston, S Brenner
GENETICS, Volume 77, Issue 1, 1 May 1974, Pages 95–104, https://doi.org/10.1093/genetics/77.1.95
Chemical analysis and a study of renaturation kinetics show that the nematode, Caenorhabditis elegans, has a haploid DNA content of 8 x IO7 base pairs (20 times the genome of E. coli). Eighty-three percent of the DNA sequences are unique…
Jonathan Hodgkin, H Robert Horvitz, Sydney Brenner
GENETICS, Volume 91, Issue 1, 10 January 1979, Pages 67–94, https://doi.org/10.1093/genetics/91.1.67
The frequency of males (5AA; XO) among the self progeny of wild-type Caenorhabditis elegans hermaphrodites (5AA; XX) is about one in 500. Fifteen him (for "high incidence of males") mutations have been identified that increase this frequency by a factor of ten to 150, as a result of increased X-chromosome nondisjunction…Carol Trent, Nancy Tsung, H Robert Horvitz
GENETICS, Volume 104, Issue 4, 1 August 1983, Pages 619–647, https://doi.org/10.1093/genetics/104.4.619
We have isolated 145 fertile mutants of C. elegans that are defective in egg laying and have characterized 59 of them genetically, behaviorally and pharmacologically. These 59 mutants define 40 new genes called egl, for egg-lay ing abnormal. Most of the other mutants are defective…
Edwin L Ferguson, H Robert Horvitz
GENETICS, Volume 110, Issue 1, 1 May 1985, Pages 17–72, https://doi.org/10.1093/genetics/110.1.17
Ninety-five mutants of the nematode Caenorhabditis elegans altered in the cell lineages of the vulva have been isolated on the basis of their displaying one of two phenotypes, Vulvaless or Multivulva. In Vulvaless mutants, which define 12 genes, no vulva is present. In Multivulva mutants, which define ten genes…
Leland H Hartwell, David Smith
GENETICS, Volume 110, Issue 3, 1 July 1985, Pages 381–395, https://doi.org/10.1093/genetics/110.3.381
Thirteen of 14 temperature-sensitive mutants deficient in successive steps of mitotic chromosome transmission (cdc2, 4, 5, 6, 7, 8, 9, 13, 14, 15, 16, 17 and 20) from spindle pole body separation to a late stage of nuclear division exhibited a dramatic increase in the frequency of chromosome loss and/or mitotic recombination…G Ruvkun and others
Genetics, Volume 121, Issue 3, 1 March 1989, Pages 501–516, https://doi.org/10.1093/genetics/121.3.501
We describe a general strategy for the genetic mapping in parallel of multiple restriction fragment length polymorphism (RFLP) loci. This approach allows the systematic identification for cloning of physical genetic loci within about 100 kb of any gene in Caenorhabditis elegans. We have used this strategy of parallel RFLP mapping to clone the heterochronic gene lin-14, which controls the timing and sequence of many C. elegans postembryonic developmental events.
T Schüpbach, E Wieschaus
GENETICS, Volume 129, Issue 4, 1 December 1991, Pages 1119–1136, https://doi.org/10.1093/genetics/129.4.1119
In mutagenesis screens for recessive female sterile mutations on the second chromosome of Drosophila melanogaster 528 lines were isolated which allow the homozygous females to survive but cause sterility. In 62 of these lines early stages of oogenesis are affected, and these females usually do not lay any eggs…R E Ellis, D M Jacobson, H R Horvitz
GENETICS, Volume 129, Issue 1, 1 September 1991, Pages 79–94, https://doi.org/10.1093/genetics/129.1.79
After programmed cell death, a cell corpse is engulfed and quickly degraded by a neighboring cell. For degradation to occur, engulfing cells must recognize, phagocytose and digest the corpses of dying cells. Previously, three genes were known to be involved in eliminating cell corpses in the nematode Caenorhabditis elegans…
L C Kadyk, L H Hartwell
GENETICS, Volume 132, Issue 2, 1 October 1992, Pages 387–402, https://doi.org/10.1093/genetics/132.2.387
A diploid Saccharomyces cerevisiae strain was constructed in which the products of both homolog recombination and unequal sister chromatid recombination events could be selected. This strain was synchronized in G1 or in G2, irradiated with X-rays to induce DNA damage…
P G Okkema, S W Harrison, V Plunger, A Aryana, A Fire
GENETICS, Volume 135, Issue 2, 1 October 1993, Pages 385–404, https://doi.org/10.1093/genetics/135.2.385
Four Caenorhabditis elegans genes encode muscle-type specific myosin heavy chain isoforms: myo-1 and myo-2 are expressed in the pharyngeal muscles; unc-54 and myo-3 are expressed in body wall muscles. We have used transformation-rescue and lacZ fusion assays…
William G Kelly, SiQun Xu, Mary K Montgomery, Andrew Fire
GENETICS, Volume 146, Issue 1, 1 May 1997, Pages 227–238, https://doi.org/10.1093/genetics/146.1.227
In screening for embryonic-lethal mutations in Caernorhabditis elegans, we defined an essential gene (let-858) that encodes a nuclear protein rich in acidic and basic residues. We have named this product nucampholin…
Siyuan Le, J Kent Moore, James E Haber, Carol W Greider
GENETICS, Volume 152, Issue 1, 1 May 1999, Pages 143–152, https://doi.org/10.1093/genetics/152.1.143
Telomere length is maintained by the de novo addition of telomere repeats by telomerase, yet recombination can elongate telomeres in the absence of telomerase. When the yeast telomerase RNA component, TLC1, is deleted, telomeres shorten and most cells die…
Anuranjan Anand, Adriana Villella, Lisa C Ryner, Troy Carlo, Stephen F Goodwin, et al.
GENETICS, Volume 158, Issue 4, 1 August 2001, Pages 1569–1595, https://doi.org/10.1093/genetics/158.4.1569
A multibranched hierarchy of regulatory genes controls all aspects of somatic sexual development in Drosophila melanogaster. One branch of this hierarchy is headed by the fruitless (fru) gene and functions in the central nervous system, where it is necessary for male courtship…
Joshua A Arribere, Ryan T Bell, Becky X H Fu, Karen L Artiles, Phil S Hartman, et al
GENETICS, Volume 198, Issue 3, 1 November 2014, Pages 837–846, https://doi.org/10.1534/genetics.114.169730
Facilitated by recent advances using CRISPR/Cas9, genome editing technologies now permit custom genetic modifications in a wide variety of organisms. Ideally, modified animals could be both efficiently made and easily identified with minimal initial screening and without introducing exogenous…
Ann K Corsi, Bruce Wightman, Martin Chalfie
GENETICS, Volume 200, Issue 2, 1 June 2015, Pages 387–407, https://doi.org/10.1534/genetics.115.176099
A little over 50 years ago, Sydney Brenner had the foresight to develop the nematode (round worm) Caenorhabditis elegans as a genetic model for understanding questions of developmental biology and neurobiology…
Nobel Laureates Published in GENETICS
Click on the links below to access papers by all of the Nobel Laureates published by GENETICS.
Chemistry
Paul ModrichMartin Chalfie
Sidney Altman
Paul Berg
Physiology or Medicine
Svante Pääbo
Victor Ambros
Gary Ruvkun
Jeffrey C. Hall
Michael Rosbash
Michael W. Young
Randy W. Schekman
Elizabeth H. Blackburn
Carol W. Greider
Jack W. Szostak
Mario Capecchi
Martin J. Evans
Oliver Smithies
Andrew Z. Fire
Craig C. Mello
Sydney Brenner
H. Robert Horvitz
John E. Sulston
Leland H. Hartwell
Paul M. Nurse
Eric R. Kandel
Stanley B. Prusiner
Edward B. Lewis
Christiane Nüsslein-Volhard
Eric F. Wieschaus
Barbara McClintock
George D. Snell
Werner Arber
Renato Dulbecco
Gerald M. Edelman
Max Delbrück
Alfred D. Hershey
Salvador E. Luria
François Jacob
Jaques Monod
George W. Beadle
Edward L. Tatum
Joshua Lederberg
Hermann J Muller
