Norepinephrine Uptake by the Myocardium of the Senescent Mouse in Vitro

Hody, George; Jonec, Viliam; Morton-smith, William; Finch, Caleb E.

doi:10.1093/geronj/30.3.275

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Norepinephrine Uptake by the Myocardium of the Senescent Mouse in Vitro

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Abstract

Age-related delays in the uptake of norepinephrine (NE) by the rat myocardium were observed after subcutaneous injection of NE (Gey, Burkard, & Pletscher, 1965). We report here that in vitro uptake of ³H-NE by myocardial slices from healthy C57BL/6J male mice is not impaired by aging (8-28 mo.) at O.1 ng/ml, 2.0 ng/ml, 1000 ng/ml of NE. Additionally, no age-related changes of inulin space in myocardial slices were observed. Hence, the delayed uptake observed in vivo by Gey et al. may be attributed to age-related changes in the absorption from the subcutaneous site.

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Norepinephrine Uptake by the Myocardium of the Senescent Mouse in Vitro

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