LOWER ANKLE-BRACHIAL INDEX (ABI) AS A PREDICTOR OF FUTURE COGNITIVE DECLINE AMONG COMMUNITY-DWELLING OCTOGENARIANS: THE KOCOA PROJECT.

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T. Tokashiki ¹ , A. Ishida ¹ , Y. Namihira ¹ , J. Nishihira ¹ , Y. Higashiuesato ² , Y. Ohya ¹ , 1. Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, Okinawa, Japan,2. Department of Clinical Laboratory, University of the Ryukyus, Okinawa, Japan

The aim of this study was to determine the association between the ankle brachial index (ABI), brachial-ankle pulse wave velocity (baPWV) and cognitive decline among community-dwelling octogenarians living in Okinawa, Japan.The data came from the KOCOA project, a pilot longitudinal cohort study of healthy volunteers aged 80 and older. Out of 197 participants assessed in 2007 (baseline) with ABI and baPWV information by an automatic oscillometric method, fifty-nine participants were reassessed 4 years later and used in this study. Cognitive decline was defined as decline in Mini Mental State Examination (MMSE) scores by 5 or more points. Eight participants had cognitive declines. ABI at baseline was lower among the cognitive decliners compared with non-decliners. In the multiple logistic regression analyses, lower ABI at baseline was significantly associated with cognitive decline, while baPWV was not.ABI measurement is useful for identifying those at risk of cognitive declines.