Molecular basis of pluripotency

Chen, Lingyi; Daley, George Q.

doi:10.1093/hmg/ddn050

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Molecular basis of pluripotency

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Abstract

Embryonic stem (ES) cells are pluripotent and capable of self-renewal, thus holding promise for regenerative medicine. Recent studies have begun to provide insights into the molecular mechanisms underlying pluripotency and self-renewal. In this article, we discuss the roles of transcriptional regulation, epigenetic regulation and miRNAs in the maintenance of pluripotency and the differentiation of ES cells.

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Molecular basis of pluripotency

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