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Ali Amin Al Olama, Zsofia Kote-Jarai, Fredrick R. Schumacher, Fredrik Wiklund, Sonja I. Berndt, Sara Benlloch, Graham G. Giles, Gianluca Severi, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, David J. Hunter, Brian E. Henderson, Michael J. Thun, Michael Gaziano, Edward L. Giovannucci, Afshan Siddiq, Ruth C. Travis, David G. Cox, Federico Canzian, Elio Riboli, Timothy J. Key, Gerald Andriole, Demetrius Albanes, Richard B. Hayes, Johanna Schleutker, Anssi Auvinen, Teuvo L.J. Tammela, Maren Weischer, Janet L. Stanford, Elaine A. Ostrander, Cezary Cybulski, Jan Lubinski, Stephen N. Thibodeau, Daniel J. Schaid, Karina D. Sorensen, Jyotsna Batra, Judith A. Clements, Suzanne Chambers, Joanne Aitken, Robert A. Gardiner, Christiane Maier, Walther Vogel, Thilo Dörk, Hermann Brenner, Tomonori Habuchi, Sue Ingles, Esther M. John, Joanne L. Dickinson, Lisa Cannon-Albright, Manuel R. Teixeira, Radka Kaneva, Hong-Wei Zhang, Yong-Jie Lu, Jong Y. Park, Kathleen A. Cooney, Kenneth R. Muir, Daniel A. Leongamornlert, Edward Saunders, Malgorzata Tymrakiewicz, Nadiya Mahmud, Michelle Guy, Koveela Govindasami, Lynne T. O'Brien, Rosemary A. Wilkinson, Amanda L. Hall, Emma J. Sawyer, Tokhir Dadaev, Jonathan Morrison, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas Van As, Christopher J. Woodhouse, Alan Thompson, Tim Dudderidge, Chris Ogden, Colin S. Cooper, Artitaya Lophatonanon, Melissa C. Southey, John L. Hopper, Dallas English, Jarmo Virtamo, Loic Le Marchand, Daniele Campa, Rudolf Kaaks, Sara Lindstrom, W. Ryan Diver, Susan Gapstur, Meredith Yeager, Angela Cox, Mariana C. Stern, Roman Corral, Markus Aly, William Isaacs, Jan Adolfsson, Jianfeng Xu, S. Lilly Zheng, Tiina Wahlfors, Kimmo Taari, Paula Kujala, Peter Klarskov, Børge G. Nordestgaard, M. Andreas Røder, Ruth Frikke-Schmidt, Stig E. Bojesen, Liesel M. FitzGerald, Suzanne Kolb, Erika M. Kwon, Danielle M. Karyadi, Torben Falck Orntoft, Michael Borre, Antje Rinckleb, Manuel Luedeke, Kathleen Herkommer, Andreas Meyer, Jürgen Serth, James R. Marthick, Briony Patterson, Dominika Wokolorczyk, Amanda Spurdle, Felicity Lose, Shannon K. McDonnell, Amit D. Joshi, Ahva Shahabi, Pedro Pinto, Joana Santos, Ana Ray, Thomas A. Sellers, Hui-Yi Lin, Robert A. Stephenson, Craig Teerlink, Heiko Muller, Dietrich Rothenbacher, Norihiko Tsuchiya, Shintaro Narita, Guang-Wen Cao, Chavdar Slavov, Vanio Mitev, The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, The UK ProtecT Study Collaborators, The Australian Prostate Cancer Bioresource, The PRACTICAL Consortium, Stephen Chanock, Henrik Gronberg, Christopher A. Haiman, Peter Kraft, Douglas F. Easton, Rosalind A. Eeles, A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease, Human Molecular Genetics, Volume 22, Issue 2, 15 January 2013, Pages 408–415, https://doi.org/10.1093/hmg/dds425
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Abstract
Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03–1.21), P = 1.4 × 10−8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.
