A Gne knockout mouse expressing human V572L mutation develops features similar to distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy

Human Molecular Genetics Advance Access published on December 12, 2006 Human Molecular Genetics16 , 115–128; (2007) doi:10.1093/hmg/ddl446

The authors deeply regret that the transgenic mice studied did not have a cDNA with a human GNE transgene containing the V572L missense mutation, which is the most common mutation in Japanese patients with distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy (DMRV/hIBM). Instead, the transgenic mice used in the reported experiments contained a cDNA with the missense mutation D176V, the second most common mutation in Japanese patients with DMRV/hIBM. The authors maintain that all other data remain accurate and have been verified by repeated experiments. Thus, the authors' conclusion that this mouse resembles the human DMRV phenotype prevails. However, in view of potential confusion in the literature, especially that the GNE mutation was explicitly written in the title and repeatedly mentioned in the text, the authors would like to retract the paper from publication. The authors sincerely apologize to the Editors of Human Molecular Genetics and the general public for any inconvenience this has caused.