Retracted: Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington’s disease

Human Molecular Genetics, 2013, 22(6), 1112–1131.

doi: 10.1093/hmg/dds516

The corresponding author requests retraction of the above referenced article due to inappropriate manipulation and fabrication of data by the first author Dr. Antonio Valencia related to Figures 1 A–D and Figure 9 C and F. This misrepresentation led to an incorrect conclusion in the paper that NADPH activity is elevated in Huntington’s disease (HD). Some original data were missing and efforts to replicate findings using the reported method or an alternative approach were unsuccessful. An institutional faculty panel supports the decision and the reasons for the retraction.