Mitochondria are the powerhouses of cell and play crucial roles in proper oocyte competence, fertilization, and early embryo development. Maternally inherited mitochondrial DNA (mtDNA) mutations can have serious implications for individuals, leading to life-threatening disorders and contribute to ...
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STUDY QUESTION Do the diagnostic delay and symptoms differ between endometriosis patients with advanced disease, defined as endometriosis involving the vagina, intestine, rectovaginal septum, or bladder (eVIRB), compared to patients without endometriosis in these locations (non-eVIRB)? SUMMARY ANSWER Patients with advanced ...
STUDY QUESTION Is patient consent to research associated with the distribution of population characteristics and study outcomes in ART cohort studies? SUMMARY ANSWER The distribution of population characteristics in the patient consent subset differs from that in the non-consent subset and is not fully representative of ...
STUDY QUESTION What is the optimal sperm concentration threshold for screening Y-chromosome microdeletions (YCMs) in male infertility patients? SUMMARY ANSWER This study identified three clinically relevant screening thresholds: an receiver operating characteristic (ROC)-optimal cutoff at 0.45 million sperm/ml, a ...
STUDY QUESTION Do IVF outcomes differ in patients over the age of 40 using donor oocytes? SUMMARY ANSWER Even with the use of donor oocytes, maternal age appears to have an impact on live birth (LB) rate and perinatal outcomes. WHAT IS KNOWN ALREADY Maternal age has a significant impact on the outcome of IVF, mainly ...
STUDY QUESTION What are the plasma metabolomics profiles associated with endometriosis in adolescents and young adults? SUMMARY ANSWER Our findings show dysregulation of plasma metabolomic profiles in adolescents and young adults with endometriosis, revealing systemic elevation of fatty acyls and ceramides in endometriosis ...
STUDY QUESTION Which phenotypes can be confidently linked to a genetic etiology in males with congenital hypogonadotropic hypogonadism (CHH) resulting in absent or arrested puberty? SUMMARY ANSWER In this systematic review and reclassification of the disease-causing potential of gene variants using the recommendations of ...
STUDY QUESTION What are the key factors that influence couples’ decision not to return for fertility treatment after their first consultation? SUMMARY ANSWER Advanced maternal age, lower ovarian reserve, and eligibility for heterologous fertilization are primary determinants of non-return among couples. WHAT IS KNOWN ...
Mitochondria are the powerhouses of cell and play crucial roles in proper oocyte competence, fertilization, and early embryo development. Maternally inherited mitochondrial DNA (mtDNA) mutations can have serious implications for individuals, leading to life-threatening disorders and contribute to ovarian ageing and female ...
STUDY QUESTION Do the main psychoactive phytocannabinoid delta-9-tetrahydrocannabinol (THC) and its non-psychoactive analog cannabidiol (CBD) affect human sperm function? SUMMARY ANSWER THC and CBD affect the sperm-specific Ca 2+ channel CatSper, suppress activation of the channel by progesterone (P4) and prostaglandin E1 ...
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