Sir,

We read with interest the recent intention to treat analysis by Murugappan and colleagues comparing the pregnancy outcomes of PGS versus the expected management approach in patients with recurrent pregnancy loss (RPL) (Murugappan et al., 2016). Although the effort of performing this kind of study is commendable, since very few data are available and no general consensus has been reached to date about the usefulness of the PGS procedure in this subpopulation of patients, there are nevertheless several questionable issues related to the methodology of the study and to the clinical management of cycles that might seriously compromise the quality of the comparison made.

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The first concern relates to the allocation procedure of couples to the PGS or...

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