Human Reproduction Update (HRU) celebrates its 30th anniversary in 2025. During these three decades, HRU has benefited from the leadership of five exceptional Editors-in-Chief (EICs), each serving a six-year term. The journal was founded in 1995 by Sir Robert (Bob) Edwards, who was followed by ...
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BACKGROUND The advent of organoid culture systems has revolutionized our ability to model and study complex tissues in vitro . The placenta is one of the last human organs to have a functional organoid model developed: trophoblast organoids. These 3-dimensional structures, derived from placental ...
Mitochondrial DNA (mtDNA) diseases pose unique challenges for genetic counselling and require tailored approaches to address recurrence risks and reproductive options. The intricate dynamics of mtDNA segregation and heteroplasmy shift significantly impact the chances of having affected children. In ...
BACKGROUND Sperm head shaping, controlled by the acrosome-acroplaxome-manchette complex, represents a significant morphological change during spermiogenesis and involves numerous proteins expressed in a spatially and temporally specific manner. Defects in sperm head shaping frequently lead to ...
BACKGROUND Ovarian aging occurs earlier than the aging of many other organs and has a lasting impact on women’s overall health and well-being. However, effective interventions to slow ovarian aging remain limited, primarily due to an incomplete understanding of the underlying molecular mechanisms ...
BACKGROUND mRNA splicing is a fundamental process in the reproductive system, playing a pivotal role in reproductive development and endocrine function, and ensuring the proper execution of meiosis, mitosis, and gamete function. Trans-acting factors and cis-acting elements are key players in mRNA ...
INTRODUCTION The embryonic period in human development is the foundation of lifelong and even transgenerational health. Although previously believed to be uniform, there is increasing evidence that embryonic growth is influenced by the conditions and modifiable lifestyle factors of parents in the ...
BACKGROUND Transgender and gender diverse (TGD) people seek gender-affirming care at any age to manage gender identities or expressions that differ from their birth gender. Gender-affirming hormone treatment (GAHT) and gender-affirming surgery may alter reproductive function and/or anatomy, ...
BACKGROUND The ovarian response to gonadotropin stimulation varies widely among women, and could impact the probability of live birth as well as treatment risks. Many studies have evaluated the impact of different gonadotropin starting doses, mainly based on predictive variables like ovarian ...
BACKGROUND Varicocele is an abnormal dilation and torsion of the pampiniform venous plexus in the scrotum due to venous reflux, primarily affecting the left side. It affects 15% of men and is a prevalent contributor to male infertility. Varicocele is a complex disorder influenced by genetic, ...
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Journal Impact Factor and Ranking
Impact Factor: 14.8
5 Year Impact Factor: 17.8
Rank in Obstetrics & Gynecology: 1 out of 136
Rank in Reproductive Biology: 1 out of 39
*This information is taken from the Journal Citation ReportsTM from Clarivate, 2024.
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Dr Madelon van Wely
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