Associative Imagery as a Strategy to Improve Destination Memory in Younger and Older Adults

Abstract Destination memory errors (inability to remember to whom information was shared) affects all ages, but older adults are particularly vulnerable due to poor source monitoring. Individuals may assume information was already shared when it was not or repeat previously shared information. The current study explored two mental imagery strategies (vivid imagery, visualizing context) to improve destination memory. Using a software program, younger and older adults told randomly generated facts to random celebrity faces. Participants were unaware of the upcoming memory tests. The control group did not use a strategy. The imagery group used vivid imagery to connect the fact and face (e.g., visualize Oprah on a dime to remember Oprah was told that dimes have 118 ridges). The context group visualized a provided context (e.g., grocery store) when telling a fact to a face. Assessments of performance on item memory (facts, faces) as well as destination memory (face-fact pairings) were counterbalanced. Results indicated an associative memory deficit among older adults, which was driven by a higher rate of false alarms. However, across all adults, the vivid imagery condition was more accurate than the control condition, and they demonstrated fewer false alarms. These findings suggest that older adults can use mental imagery to reduce false alarms and improve destination memory performance. Implications include reducing age stereotypes, improving conversations, and decreasing potentially dangerous situations (e.g., withholding important health information thinking it already was shared with a doctor).


5-COG STUDY: CROSS-CULTURAL COMPARISON OF SUBJECTIVE COGNITIVE COMPLAINTS IN A DIVERSE PRIMARY CARE POPULATION
Emmeline Ayers, 1 Erica F. Weiss, 2 and Joe Verghese, 1 1. Albert Einstein College of Medicine,Bronx,New York,United States,2. Montefiore Medical Center,Bronx,New York,United States Subjective cognitive complaints (SCC) are risk factors for cognitive decline in older adults. A link between SCC and depressive symptoms has also been reported. These associations have not been much studied in non-White populations. We examined the relationship of SCC with cognitive function and depressive symptoms in adults aged 65 and older attending a primary care clinic in the Bronx. Five common SCC questions (four memory-related and one non-memoryrelated) were identified by literature review. Linear regressions, adjusted for age, sex and education years, were used to examine associations between individual SCC and cognitive function (Montreal Cognitive Assessment (MoCA) score and Hopkins Verbal Learning Test (HVLT) recall score) and depressive symptoms (Geriatric Depression Scale (GDS) score) for Hispanic (n=53) and non-Hispanic Black (n=47) adults. Mean number of SCC was similar for Blacks and Hispanics (2.3 vs. 2.4, p=0.752). Hispanics performed worse on the MoCA than Blacks (16.4 vs. 18.5,p=0.012), but education explained this difference. GDS and HVLT were similar across groups. For Hispanics only, a response of fair or poor to the question "how is your memory for a person your age?" was associated with worse MoCA scores (β -2.6; p=0.008). SCC were not associated with HVLT scores for either group. Four SCC for Blacks and two for Hispanics were associated with worse GDS scores. In an urban clinic population, SCC for Blacks and Hispanics were associated more with depressive symptoms than cognition. Further research is needed to identify SCC that better correlate with cognitive function in diverse populations.

AGE-RELATED PATTERNS IN THE SUBJECTIVE APPRAISAL OF COGNITION
Claudia Jacova, 1 Samantha Smith, 2 and Frank Robertson, 1 1. Pacific University,Hillsboro,Oregon,United States,2. Student,Hillsboro,Oregon,United States Subjective cognitive decline (SCD) is a construct of high interest in aging and dementia because individuals endorsing it are at higher risk of developing cognitive problems. It is unclear how individuals arrive at the judgement that they have SCD. Here we aimed to understand which SCD symptoms give rise to the perception of decline as older adults age. Community-dwelling adults (N=494, mean age=63.6, SD=5.44), completed the Subjective Cognitive Decline Questionnaire (SCD-Q) online, using an online crowdsourcing site. The SCD-Q consists of one global question regarding self-perceived decline (yes/no) and 24 questions about everyday functioning which we utilized to form a memory, language, and executive functioning domain score, higher for greater perceived decline. Logistic regression revealed that memory and language domains predicted the likelihood of endorsing SCD for adults aged >64 (Memory: OR=1.76, CI=1.47-2.05; Language: OR=1.66, CI=1.30-2.02). Only the memory domain predicted the likelihood of endorsing SCD for adults <63 (OR=2.69, CI=2.35-3.02). Executive functioning domain scores did not play a role in the relationship between SCD likelihood in either age group. The higher the self-perceived memory or language decline, the more likely older adults are to conclude they have SCD. Our results suggest there is an age-related trajectory in how people evaluate their cognition, with younger people only considering memory and older people considering both memory and language. Clinicians should be aware of this trajectory when examining patients with SCD. Executive functions should be specifically queried because they may not emerge from older adults' self-reported cognitive problems. Destination memory errors (inability to remember to whom information was shared) affects all ages, but older adults are particularly vulnerable due to poor source monitoring. Individuals may assume information was already shared when it was not or repeat previously shared information. The current study explored two mental imagery strategies (vivid imagery, visualizing context) to improve destination memory. Using a software program, younger and older adults told randomly generated facts to random celebrity faces. Participants were unaware of the upcoming memory tests. The control group did not use a strategy. The imagery group used vivid imagery to connect the fact and face (e.g., visualize Oprah on a dime to remember Oprah was told that dimes have 118 ridges). The context group visualized a provided context (e.g., grocery store) when telling a fact to a face. Assessments of performance on item memory (facts, faces) as well as destination memory (face-fact pairings) were counterbalanced. Results indicated an associative memory deficit among older adults, which was driven by a higher rate of false alarms. However, across all adults, the vivid imagery condition was more accurate than the control condition, and they demonstrated fewer false alarms. These findings suggest that older adults can use mental imagery to reduce false alarms and improve destination memory performance. Implications include reducing age stereotypes, improving conversations, and decreasing potentially dangerous situations (e.g., withholding important health information thinking it already was shared with a doctor).

CHRONIC STRESS, C-REACTIVE PROTEIN, AND COGNITION AMONG RACIALLY AND ETHNICALLY DIVERSE OLDER ADULTS Emily Morris, and Laura Zahodne, University of Michigan, Ann Arbor, Michigan, United States
Objective: Previous research suggests that chronic stress is associated with worse cognitive aging, but minimal research has examined potential mechanisms and moderators of these associations. Chronic stress is known to increase inflammation (e.g., C-reactive protein [CRP]), which has in turn been associated with worse cognition among older adults. The present study examined whether (1) CRP mediates associations between chronic stress and episodic memory and verbal fluency; and (2) these relationships differ by race/ ethnicity. Methods: Participants included 18,968 adults (64% non-Hispanic White; 19% non-Hispanic Black; 14% Hispanic; 3% non-Hispanic other race/ethnicity; Mage=71.8; SDage=6.0) from the Health and Retirement Study. Chronic stress was operationalized as the occurrence and impact of eight ongoing stressors. Cross-sectional, stratified mediation models were conducted for three cognitive outcomes: immediate recall, delayed recall, and verbal fluency. Covariates included sociodemographics and vascular disease burden. Results: Chronic stress was associated worse immediate recall (beta=-.028). Higher CRP was not associated with any cognitive domains. Non-Hispanic Black participants reported more chronic stress than non-Hispanic White and Hispanic participants. Chronic stress was less strongly associated with higher CRP in non-Hispanic Black (beta=-.035) participants than non-Hispanic White (beta=.046) or Hispanic (beta=.059) participants. Discussion: Chronic stress may negatively influence episodic memory, but findings do not suggest that CRP mediates links between chronic stress and cognition. CRP may not track as closely with chronic stress among non-Hispanic Black older adults who may experience additional risk factors for inflammation and/ or adapt to increased chronic stress.

CORTISOL RESPONSES TO A LABORATORY CHALLENGE: THE MODERATING ROLE OF COGNITIVE PERFORMANCE
Elise Grimm, 1 and Stefan Agrigoroaei, 2 1. Universite Catholique de Louvain,Belgium,2. UCLouvain,Belgium,Belgium Recent theoretical and empirical studies have considered higher cognitive performance as a protective factor with respect to reactivity, recovery and habituation to acute stressors. The goal of our study was to examine the individual role of inhibition, working memory, processing speed, reasoning, and category fluency in the regulation of the cortisol response to a laboratory challenge. Younger, middle-aged, and older participants (N =109,M=55.90,SD=16.35) were invited to a laboratory session comprising a driving simulation and a set of cognitive tasks. At least one week in advance, baseline cognitive performance was measured using the Brief Test of Adult Cognition by Telephone (BTACT). Throughout the lab session, five saliva samples were taken, which allowed for the computation of a global measure of cortisol release (area under the curve (AUC)). Cortisol AUC was regressed on the individual BTACT cognitive tests, while controlling for age, sex, education, body mass index, physical activity, and time since awakening. The results revealed that inhibition and working memory significantly accounted for the cortisol response. These associations remained significant when other factors such as smoking, caffeine consumption, and medication use were included as covariates. The contributions of reasoning and speed of processing approached significance. Our findings contribute to the emerging evidence that cognitive functioning modulates stress responses to acute stressors. The findings are discussed in the context of cognitive interventions with transfers and implications for stress processes and healthy aging.

DEVELOPMENTAL TRAJECTORY OF THEORY-OF-MIND DECLINE IN OLDER ADULTS
W. Quin Yow, Xiaoqian Li, and Jiawen Lee, Singapore University of Technology & Design, Singapore, Singapore Theory-of-Mind (ToM) is critical to individual social competence and mental health across the lifespan (Frith, 2008). Though it is often discussed as one broad construct, ToM abilities can be viewed as following a developmental trajectory: from early emotion recognition and gaze following to more advanced inferences about others' beliefs, perspectives, and intentions (Hutchins et al., 2012). Despite current literature suggesting that ToM abilities may be impaired in late adulthood, there is no consensus regarding whether ToM abilities are differentially affected by age. In this study, we examined younger adults (N=18, aged 19-30) and older adults (N=13, aged 58-76) on their ToM competence across three levels of ToM abilities: Early-ToM (e.g.,