MUSIC ENGAGEMENT AND EPISODIC MEMORY AMONG MIDDLE-AGED AND OLDER ADULTS: A NATIONAL LONGITUDINAL ANALYSIS MODERATORS OF THE OF

Recent research suggests that engagement with particular activities, such as music, can influence age-related changes in episodic memory. However, it is unclear whether, and to what, extent music engagement is associated with the tra-jectory of episodic memory. The objective of this study is to examine how passive (i.e., listening to music) and/or ac-tive (i.e., singing or playing an instrument) music engagement influences episodic memory over a period of 12 years. Secondary data analysis of a sample (N=5095) of cognitively healthy adults from the Health and Retirement Study were used for this study. Linear mixed effects models were used to examine the independent effect of different levels of music engagement (i.e., low, medium, and high) on changes in performance on episodic memory tasks, while controlling for confounding factors. Compared to those with low engagement (i.e., neither listening nor singing/ playing an instrument), respondents who reported being engaged at the medium (i.e., either listening or singing/ playing an in-strument) or high (i.e., both listening and singing/ playing an instrument) level performed 0.24 (p=0.003) and 0.52 (p<0.001) points better, respectively. We found evidence that music engagement attenuated the decline in episodic memory. The findings suggest that music engagement may be a protective factor against aged-related decline in episodic memory. Therefore, music engagement may offer a prom-ising non-pharmacological intervention for dementia risk mitigation among community-living middle-aged and older adults. Future research should examine whether interven-tions to increase music engagement can affect the trajectories of aged-related decline in cognition in this large and growing population. between to examine the effects of individ-uals, cities, and time on older people’s cognitive function in the the of and


NEUROANATOMICAL MODERATORS OF THE IMPACT OF MILD BEHAVIORAL IMPAIRMENT ON COGNITION
Hillary Rouse, 1 and Brent Small, 2 , 1. University of South Florida, TAMPA,Florida,United States,2. University of South Florida,Tampa,Florida,United States Older adults with mild behavioral impairment (MBI), or the presence of late-life neuropsychiatric symptoms, have a unique cognitive phenotype. However, the neural correlates associated with MBI-related cognitive changes is not well understood. The goal of this study is to examine if specific regions of the brain moderate the relationship between the presence of MBI and performance on tasks of cognition. Data from the National Alzheimer's Coordinating Center was utilized for this study. Participants (N=1,451) were included in our analyses if they were cognitively healthy or had mild cognitive impairment (MCI). Multiple domains of cognitive performance were evaluated. The neuroanatomical regions included hippocampus, caudal anterior cingulate (ACC), rostral ACC, entorhinal, and parahippocampal gray matter volume; and caudal ACC, rostral ACC, entorhinal, and parahippocampal mean cortical thickness. Hippocampal, entorhinal, and parahippocampal cortical gray matter volume moderated the relationship between MBI and performance on tasks of episodic memory. Left rostral ACC cortical gray matter volume and entorhinal and parahippocampal mean cortical thickness moderated the relationship between MBI and performance on language tasks. Hippocampi cortical gray matter volume also moderated the relationship between MBI and performance on processing speed tasks. Persons with smaller brain sizes in these areas were more negatively affected in these cognitive domains if they had MBI. These results suggest that the association between smaller brain volumes and cognition was stronger among persons with MBI. These findings suggest that older adults with MBI may perform worse on these tasks due to neurodegeneration that is present.

Hui-chuan Hsu, and Chyi-Huey Bai, Taipei Medical University, Taipei, Taipei, Taiwan (Republic of China)
Purpose: Individual's factors across time or combined with area characteristics related to cognitive function for older people have been widely explored, but little research examined person, place, and time effects altogether. The purpose of this study was to examine the effects of individuals, cities, and time on older people's cognitive function in Taiwan.
Methods: A nation-representative longitudinal individual data were from Taiwan Longitudinal Survey on Aging (TLSA) 1999-2015 panel data (analysis sample n=6349 persons, observations=12042). Cognitive function was scored 0-19. Individual's factors included demographics, health conditions and health behaviors, mental health and stress, social support and social participation, etc. Eleven city-level indicators were based on 22 cities and data were from the government open data sources. Mixed linear modeling analysis was applied.
Results: Better cognitive function was significantly related to individuals' working, ethnicity, younger age, better education level, better self-rated health, less psychological stress, receiving more emotional support, having higher economic satisfaction at the intercept. Sex, ethnicity, age, education, self-rated health, physical function, and social connectedness were significant at the time slope. When controlling for individuals' factors, population density and green land were significant at the intercept and at the time slope. Interactions of individual-and city-level factors were not significant.
Discussion: Individual's social participation and social support are protective factors of cognitive function for older adults. And an age-friendly environment providing appropriate cognitive stimulation and chances of social participation may be beneficial for cognitive function.