EFFECT OF A 6-MONTH HOME-BASED WALKING PROGRAM ON COGNITIVE FITNESS IN OLDER ADULTS WITH CHRONIC KIDNEY DISEASE

Abstract We have previously demonstrated that cognitive status and white matter integrity are highly associated with physical fitness in older adult patients with chronic kidney disease (CKD). We present data from a two group RCT determining effect of a 6-month home-based walking intervention on physical and cognitive fitness compared to usual care. The intervention included use of a wearable activity monitor, weekly didactic phone meetings, interactive tools and monthly coach-delivered feedback. The intervention group had a 78% compliance rate to the 6-month exercise program (159.9 (149.2) minutes/week). Executive function composite score and global cognitive for intervention group > than control group. Additionally, global white matter integrity and functional connectivity improved in the intervention group and declined in the usual care group. We conclude that a home-based physical activity intervention can have significant improvement on cognitive health and neuroplasticity in older adults with CKD and lowering their risk of developing AD/ADRD

Dr. Bhatt will discuss the differences in types of cognitive motor interference patterns experienced for different tasks (gaitand volitional versus reactive balance) in cognitively intact versus people with mild cognitive impairment. She will discuss the effectiveness of dualtask training and exergaming on gait, volitional and reactive balance control in older adults with mild cognitive impairment. After 4 weeks of such training, the results showed beneficial effects on improving volitional based performance when performed with a cognitive task (i.e., spatial memory and executive function) and had significant improvement in NIH toolbox (cognitive-increased working memory, episodic memory and executive function, and motor-increased gait speed). However, its positive effects on dual task reactive balance control were limited. Additionally, the speaker will go on to discuss the associations of balance control deficits in mild cognitive impairment with neural correlates (structural and functional brain integrity) to understand the attributing factors to increased fall risk in people with mild cognitive impairment.

ENHANCING WELL-BEING THROUGH EXERCISE DURING OLDER AGE David Marquez, University of Illinois Chicago, Chicago, Illinois, United States
Dr. Marquez's Roybal pilot Enhancing Well-Being Through Exercise During Older Age piloted an adaptation of a group exercise evidence-based program for people with arthritis symptoms, Fit & Strong!, that included education on emotional wellbeing and mental health. The pilot used a waitlist design to test the 8-week program among Black residents reporting depressive symptoms living in a senior housing facility. A battery of physical, emotional, and cognitive outcomes were collected pre and post intervention and a subset of participants (n=11) received MRIs pre and post. The sample included 28 participants (n=13 intervention, n=15 waitlist) who had a mean age of 69.8, were 89% female, reported a mean of 3.6 chronic conditions, and an average WOMAC pain score of 5.7 (moderate pain). Though under-powered, analyses show greater improvements in key physical activity and cognitive domains among the intervention group compared to the waitlist group.

EFFECT OF A 6-MONTH HOME-BASED WALKING PROGRAM ON COGNITIVE FITNESS IN OLDER ADULTS WITH CHRONIC KIDNEY DISEASE Ulf Bronas, University of Illinois Chicago, Chicago, Illinois, United States
We have previously demonstrated that cognitive status and white matter integrity are highly associated with physical fitness in older adult patients with chronic kidney disease (CKD). We present data from a two group RCT determining effect of a 6-month home-based walking intervention on physical and cognitive fitness compared to usual care. The intervention included use of a wearable activity monitor, weekly didactic phone meetings, interactive tools and monthly coach-delivered feedback. The intervention group had a 78% compliance rate to the 6-month exercise program (159.9 (149.2) minutes/week). Executive function composite score and global cognitive for intervention group > than control group. Additionally, global white matter integrity and functional connectivity improved in the intervention group and declined in the usual care group. We conclude that a home-based physical activity intervention can have significant improvement on cognitive health and neuroplasticity in older adults with CKD and lowering their risk of developing AD/ADRD

NOVEL GENOMIC AND EXCEPTIONAL LONGEVITY FINDINGS FROM THE LONG LIFE FAMILY STUDY Chair: Mary Wojczynski Co-Chair: Nancy W. Glynn Discussant: Evan Hadley
The Long Life Family Study (LLFS), funded by the National Institute on Aging, is an international collaborative study of the genetics and familial components of exceptional longevity and healthy aging. We phenotyped 4,953 individuals from 539 two-generational families (1,727 proband; 3,226 offspring) at baseline (2006)(2007)(2008)(2009). A second visit (2014-2017) was conducted for 2,904 (478 proband; 2,426 offspring) participants. The longitudinal, comprehensive in-person visits measured domains of healthy aging, including physical performance, cognition, and blood markers. Extensive genetic analyses were performed using the baseline blood draw, including genotyping with the Illumina 2.5M Human Omni array, linkage analyses with the families, whole genome sequencing using the TopMED protocol, and metabolomic assays. Collectively, this symposium will present novel findings that examined differences in end of life events and cause of death between non-exceptional and exceptional long-lived women, elucidate potential rare variants associated with exceptional longevity, and examine new potential metabolomics pathways involved in gait speed and cardiovascular disease. Specifically, Dr. Galvin will share results from three Danish nationwide studies (including LLFS) on different end of life events in long-lived female siblings. Then, Dr. Gurinovich will share findings on new uncommon variants associated with extreme longevity. Next, Dr. Kuipers will discuss associations between lipid metabolomics and vascular health. Lastly, Dr. Santanasto will discuss lipid metabolomics associated with lower odds of slow gait speed. Dr. Evan Hadley, NIA, will be the discussant and will share insights and propose future directions for LLFS.

END-OF-LIFE EVENTS AND CAUSES OF DEATH IN DANISH LONG-LIVED FEMALE SIBLINGS
Angeline Galvin 1 , Svetlana Ukraintseva 2 , Konstantin Arbeev 2 , Mary Feitosa 3 , Anne Newman 4 , and Kaare Christensen 5 , 1. University of Southern Denmark,Odense,Syddanmark,Denmark,2. Duke University,Durham,North Carolina,United States,3. Washington University,St Louis,Missouri,United States,4. University of Pittsburgh,Pittsburgh,Pennsylvania,United States,5. Southern Denmark University,Odense,Syddanmark,Denmark Long-lived siblings have better health and survival compared to "sporadic" long-lived individuals, but it is unknown whether they also differ in end-of-life events and causes of death. Deceased Danish long-lived female siblings (n=833, mean age at death=95.6) were identified through national health registers compared to controls matched on sex, year-of-birth, and year-of-death. End-oflife events (hospitalizations, emergency room visits, medication within the five years before death) and causes of death were analyzed using linear models with fixed effects and multinomial logistic models, respectively. End-of-life events and causes of death were not statistically significantly different between long-lived female siblings and "sporadic" long-lived individuals. However, long-lived female siblings presented non-significant higher risk of ischemic heart disease and cancer -and lower risk of mental diseases and accidents. The analyses will be extended to include men, a longer follow-up, and focus on dementia in the last years of life.