T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo

Abstract

The role of IL-4, -6 and -7 in the survival of T lymphocytes was studied in vivo. The decay of polyclonal populations of CD4⁺ and CD8⁺ T cells was monitored in thymectomized anti-cytokine receptor mAb-treated and/or cytokine-deficient mice. The lack of IL-4 or -6 did not have any detectable effect on T cell survival, but IL-7 played an important role in the survival of the naive T cell compartment, especially of naive CD4⁺ T cells.

cytokine, homeostasis, IL, signaling, survival, T cell

B6 C57/Bl6, IL-7R IL-7 receptor, PE phycoerythrin