Mastic gum has no effect on Helicobacter pylori load in vivo

Abstract

Objective: To determine whether mastic gum suppresses or eradicates Helicobacter pylori infection in humans.

Patients and methods: Nine patients with H. pylori infection, and without gastroduodenal ulceration, were recruited from day-case endoscopy lists and treated with mastic 1 g four times daily for 14 days. [¹³C]Urea breath tests (UBTs) were carried out immediately before, on day 15 and 5 weeks after treatment with mastic.

Results: Mastic had no effect on H. pylori status in any of the eight completed patients; all remained H. pylori positive by UBT with no change in δ scores [pre-treatment mean ± s.e.m. 19.1 ± 3.7, day 15 (post-treatment) 18.7 ± 3.8, P = 0.8, paired t-test].

Conclusion: Despite reported anti-H. pylori action in vitro, this preliminary study shows that mastic has no effect on H. pylori in humans.

Keywords: peptic ulcers, natural treatments, dyspepsia