Volume 71, Issue 9, September 2016
Leading article
Addressing resistance to antibiotics in systematic reviews of antibiotic interventions
Garrod Lecture
The 2016 Garrod Lecture: The role of the healthcare epidemiologist in antimicrobial chemotherapy—a view from the USA
Reviews
Pneumocystis jirovecii pneumonia: still a concern in patients with haematological malignancies and stem cell transplant recipients
The risk of patients with ALL and recipients of an allogeneic HSCT developing Pneumocystis jirovecii pneumonia is sufficiently high to warrant guidelines for the laboratory diagnosis, prevention and treatment of the disease. In this issue, the European Conference on Infections in Leukemia (ECIL) presents its recommendations in three companion papers.
ECIL guidelines for the diagnosis of Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients
ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients
ECIL guidelines for treatment of Pneumocystis jirovecii pneumonia in non-HIV-infected haematology patients
ORIGINAL RESEARCH
Ten years later: still a high prevalence of MRSA in slaughter pigs despite a significant reduction in antimicrobial usage in pigs the Netherlands
A novel resistance mutation in eccC5 of the ESX-5 secretion system confers ofloxacin resistance in Mycobacterium tuberculosis
Description of compensatory gyrA mutations restoring fluoroquinolone susceptibility in Mycobacterium tuberculosis
Loss and gain of aminoglycoside resistance in global clone 2 Acinetobacter baumannii in Australia via modification of genomic resistance islands and acquisition of plasmids
Emergence and evolution of an international cluster of MDR Bacteroides fragilis isolates
Adaptive responses to cefotaxime treatment in ESBL-producing Escherichia coli and the possible use of significantly regulated pathways as novel secondary targets
Glutathione-S-transferase FosA6 of Klebsiella pneumoniae origin conferring fosfomycin resistance in ESBL-producing Escherichia coli
Novel penA mutations identified in Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone isolated between 2000 and 2014 in Japan
Molecular epidemiology and mechanisms of resistance of azithromycin-resistant Neisseria gonorrhoeae isolated in France during 2013–14
Development of a Luminex xTAG® assay for cost-effective multiplex detection of β-lactamases in Gram-negative bacteria
Benchmarking of methods for identification of antimicrobial resistance genes in bacterial whole genome data
A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication
Comparison of the antifungal activity of micafungin and amphotericin B against Candida tropicalis biofilms
What about confidence intervals? A word of caution when interpreting PTA simulations
Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling
A pharmacokinetic–pharmacodynamic model characterizing the emergence of resistant Escherichia coli subpopulations during ertapenem exposure
Pharmacodynamics of carbapenems for the treatment of Pseudomonas aeruginosa ventilator-associated pneumonia: associations with clinical outcome and recurrence
The authors were unable to find a relationship between clinical pharmacodynamic cut-offs for carbapenems for treating a patient population suffering from Pseudomonas aeruginosa ventilator-associated pneumonia despite in vitro data that suggested such a link exists.
A model-based analysis of the predictive performance of different renal function markers for cefepime clearance in the ICU
Hepatic cyst penetration of cefazolin in patients receiving aspiration sclerotherapy
Characterization of the haematological profile of 21 days of tedizolid in healthy subjects
Microbiological efficacy and tolerability of a single-dose regimen of 1 g of ceftriaxone in men with gonococcal urethritis
Treatment of MDR urinary tract infections with oral fosfomycin: a retrospective analysis
An observational study of the universal use of octenidine to decrease nosocomial bloodstream infections and MDR organisms
Outbreak of IMP-producing carbapenem-resistant Enterobacter gergoviae among kidney transplant recipients
Carriage of antimicrobial-resistant commensal bacteria in Dutch long-term-care facilities
Carriage of ESBL-producing Escherichia coli and MRSA was found to be low among residents of Dutch long-term-care facilities. However, the large variation between centres warrants integrated surveillance by linking antimicrobial usage, microbiological test results, clinical background data and epidemiological data to allow regular analysis of predictors of carriage of resistant microorganisms and evaluation of the effects of interventions considered necessary.