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Best of Journal of Antimicrobial Chemotherapy 2024
As we usher in the new year, Dr Peter Donnelly, the Editor-in-Chief of BSAC’s Journal of Antimicrobial Chemotherapy (JAC) would like to warmly thank all authors and expert peer reviewers who have contributed to the success of the journal in 2024.
To celebrate the research published in JAC, the Editor-in-Chief has selected a sample of 7 outstanding 2024 papers for you to peruse. These papers have played their part in furthering a better understanding of antimicrobial chemotherapy and resistance.
Lenacapavir is a very recent first-in-class capsid inhibitor approved for HIV-1 treatment. 1 It is a long-acting antiretroviral intended for dosing twice a year by subcutaneous injection. In combination with other antiretrovirals, lenacapavir is indicated in heavily treatment-experienced adults ...
Background MRSA is a major contributor to AMR-related deaths. The WHO’s global action plan emphasizes a One Health approach, acknowledging the connection between humans and their companion animals. It is agreed on that comprehensive AMR surveillance is needed. Objectives This study provides a ...
Background Pharmacokinetic/pharmacodynamic (PK/PD) indices are widely used for the selection of optimum antibiotic doses. For β-lactam antibiotics, fT >MIC , best relates antibiotic exposure to efficacy and is widely used to guide the dosing of β-lactam/β-lactamase inhibitor (BLI) combinations, ...
Background Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is increasing worldwide, with Mycobacterium avium complex (MAC) and Mycobacterium abscessus as the predominant pathogens. Current treatments are poorly tolerated and modestly effective, highlighting the need for new treatments. ...
Current tuberculosis and non-tuberculous mycobacterial disease guidelines recommend the use of clofazimine in a 100 mg once-daily dose. The rationale behind this exact dose is not provided. I performed a literature review to determine the reasoning behind the current dosing regimen. The current 100 ...
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