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Educational reach funnel of the program and its evaluation across all activ...
Published: 18 April 2025
Fig. 1.
Educational reach funnel of the program and its evaluation across all activity components.
Journal Article
Promoting real-world evidence use for antimicrobial stewardship in Latin America: evaluation of impact of a two-part educational webinar series
JAC-Antimicrobial Resistance, Volume 7, Issue 2, April 2025, dlaf056, https://doi.org/10.1093/jacamr/dlaf056
Published: 18 April 2025
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Frequency of learners highly likely to perform relevant behaviours.
Published: 18 April 2025
Fig. 2.
Frequency of learners highly likely to perform relevant behaviours.
Journal Article
Impact of milbemycin oxime on fluconazole resistance in Candida auris
JAC-Antimicrobial Resistance, Volume 7, Issue 2, April 2025, dlaf060, https://doi.org/10.1093/jacamr/dlaf060
Published: 12 April 2025
Journal Article
Sulbactam for carbapenem-resistant Acinetobacter baumannii infections: a literature review
JAC-Antimicrobial Resistance, Volume 7, Issue 2, April 2025, dlaf055, https://doi.org/10.1093/jacamr/dlaf055
Published: 12 April 2025
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The rationale behind the use of high-dose sulbactam against CRAB infections...
Published: 12 April 2025
Figure 1.
The rationale behind the use of high-dose sulbactam against CRAB infections. (a) Conventional-dose therapy with sulbactam may not be effective against CRAB, as this molecule can be hydrolysed by class A, ADC-type class C, OXA-type class D β-lactamases, and MBLs, which can be produced by CRAB isolate
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Measurement of the fluorescent ABC transporter substrate R6G in different ...
Published: 12 April 2025
Figure 1.
Measurement of the fluorescent ABC transporter substrate R6G in different C. auris isolates in the absence or presence of milbemycin oxime (MO). (a–d) Clinical isolates. (e–h) Laboratory-generated strains and their background strain (IV.1). Relative fluorescence was calculated from the initial flu
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Effect of pre-exposure of HSEs and PBECs to SAAP-148 on colonization by MRS...
Published: 11 April 2025
Figure 1.
Effect of pre-exposure of HSEs and PBECs to SAAP-148 on colonization by MRSA. Bacterial counts from cell-free (CF; grey) and cell-associated (CA; red) fractions of HSE and PBEC cultures after pretreatment with SAAP-148 and infection with MRSA LUH14616. HSE (a) and PBEC (b) cultures were pretreated w
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Relationship between the PK/PD indices and the antibiotic efficacy (bacteri...
Published: 11 April 2025
Figure 1.
Relationship between the PK/PD indices and the antibiotic efficacy (bacterial count at 24 h) in mice for the rich dose fractionation designs of meropenem (top row) and polymyxin B (bottom row). The simulated bacterial counts at 24 h for the different dose groups (shapes), the stasis line (horizontal
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R2 values for the different PK/PD indices (top row) and...
Published: 11 April 2025
Figure 2.
R 2 values for the different PK/PD indices (top row) and f T > MIC values required to achieve efficacy targets at 24 h (bottom row) based on E max models fitted to simulated meropenem dose fractionation studies with different alterations to the study design (first column: changes to the low
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Relative estimation errors (REEs) of parameter estimates for polymyxin B fo...
Published: 11 April 2025
Figure 5.
Relative estimation errors (REEs) of parameter estimates for polymyxin B for scenarios evaluating the inclusion of one (top row) or two (bottom row) extra time points (in hours after the start of treatment) for the evaluation of bacterial count in treatment groups. Shown are the median (solid line),
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RRMSEs of parameter estimates for PMB for scenarios evaluating the inclusio...
Published: 11 April 2025
Figure 7.
RRMSEs of parameter estimates for PMB for scenarios evaluating the inclusion of one (top row) or two (bottom row) extra time points (in hours after the start of treatment) for the evaluation of bacterial count in treatment groups. Each column presents RRMSEs for one parameter. Scenarios are indicate
Journal Article
Simulation-based evaluation of the impact of dose fractionation study design on antibiotic PKPD analyses
JAC-Antimicrobial Resistance, Volume 7, Issue 2, April 2025, dlaf057, https://doi.org/10.1093/jacamr/dlaf057
Published: 11 April 2025
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Expression of host defence peptides and inflammatory cytokines by HSEs and ...
Published: 11 April 2025
Figure 5.
Expression of host defence peptides and inflammatory cytokines by HSEs and PBECs in response to SAAP-148. HSEs and PBECs were exposed to SAAP-148 (red) or—as control—to PBS (black) for up to 24 h, and then RNA was extracted from the models for assessment of mRNA levels of LL-37 (a, CAMP ), hBD-1 (b
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Relative estimation errors (REEs) of parameter estimates for meropenem for ...
Published: 11 April 2025
Figure 4.
Relative estimation errors (REEs) of parameter estimates for meropenem for scenarios evaluating the inclusion of one (top row) or two (bottom row) extra time points (in hours after the start of treatment) for the evaluation of bacterial count in treatment groups. Shown are the median (solid line), 2
Journal Article
SAAP-148 and halicin exhibit synergistic antimicrobial activity against antimicrobial-resistant bacteria in skin but not airway epithelial culture models
JAC-Antimicrobial Resistance, Volume 7, Issue 2, April 2025, dlaf050, https://doi.org/10.1093/jacamr/dlaf050
Published: 11 April 2025
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Effect of pre-exposure of HSEs and PBECs to SAAP-148 on colonization by AMR...
Published: 11 April 2025
Figure 2.
Effect of pre-exposure of HSEs and PBECs to SAAP-148 on colonization by AMR P. aeruginosa . Bacterial counts from cell-free (CF; grey) and cell-associated (CA; red) fractions of HSE and PBEC cultures after pretreatment with SAAP-148 and infection with P. aeruginosa LUH15103. HSE (a) and PBEC (b)
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Confocal microscopy of HSEs exposed to FITC-SAAP-148. HSEs were exposed to ...
Published: 11 April 2025
Figure 3.
Confocal microscopy of HSEs exposed to FITC-SAAP-148. HSEs were exposed to either PBS for 1 h (a) or FITC-SAAP-148 (green) for 1 h (b), 6 h (c) or 24 h (d), washed, and stained with DAPI (blue, nucleus). Apical layer images (i) and orthogonal z-stack projections (ii) are shown. FITC-SAAP-148 localiz
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Confocal microscopy of PBECs treated with FITC-SAAP-148. PBEC cultures were...
Published: 11 April 2025
Figure 4.
Confocal microscopy of PBECs treated with FITC-SAAP-148. PBEC cultures were exposed to either PBS for 1 h (a) or FITC-SAAP-148 (green) for 1 h (b), 6 h (c) or 24 h (d), washed, incubated with goat anti-human EpCAM antibody overnight, then washed and stained with rabbit anti-goat IgG-Alexa Fluor™ 594
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R2 values for the different PK/PD indices (top row) and...
Published: 11 April 2025
Figure 3.
R 2 values for the different PK/PD indices (top row) and f AUC/MIC values required to achieve efficacy targets at 24 h (bottom row) based on E max models fitted to simulated polymyxin B dose fractionation studies with different alterations to the study design (first column: changes to the lowe
