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Journal Article
ACCEPTED MANUSCRIPT
Weiqi Guo and others
Journal of Applied Microbiology, lxaf097, https://doi.org/10.1093/jambio/lxaf097
Published: 24 April 2025
Journal Article
ACCEPTED MANUSCRIPT
Fernanda Carolina Veiga and others
Journal of Applied Microbiology, lxaf095, https://doi.org/10.1093/jambio/lxaf095
Published: 24 April 2025
Journal Article
ACCEPTED MANUSCRIPT
Hala R Ali and others
Journal of Applied Microbiology, lxaf099, https://doi.org/10.1093/jambio/lxaf099
Published: 23 April 2025
Journal Article
ACCEPTED MANUSCRIPT
Nathan van Wyk and others
Journal of Applied Microbiology, lxaf098, https://doi.org/10.1093/jambio/lxaf098
Published: 23 April 2025
Journal Article
ACCEPTED MANUSCRIPT
Jianqiu Chen and others
Journal of Applied Microbiology, lxaf091, https://doi.org/10.1093/jambio/lxaf091
Published: 18 April 2025
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Published: 18 April 2025
Figure 1. Representation of the reaction for the synthesis of 4C p C.
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Published: 18 April 2025
Figure 3. Measurement of death microbial time of strain MRSA NCTC13373 under the action of the 4C p C. Results are presented as mean ± SD of three independent experiments performed in triplicate (ANOVA with Tukey’s post-test, P  < .0001, except 4C p C 8 µg ml −1  vs. control at 0 h and 4C p C 16 µg ml −1
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Published: 18 April 2025
Figure 6. Transmission electron micrographs of MRSA NCTC 13373 and Enterococcus faecalis (EF) ATCC 29212 (a and b) treated with vancomycin (c and d) and 4C p C (e, f, g, and h) for 3 h. Ctrl (untreated groups), Van (vancomycin), and 4C p C (4-chlorobenzyl p -coumarate).
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Published: 18 April 2025
Figure 10. Systemic toxicity of 4C p C in a Galleria mellonella larvae model. The larvae received treatment with 4C p C at concentrations of 3.47, 6.94, 13.89, 27.77, 55.54, 111.09, 222.18, 444.37, and 888.73 µmol l −1 (1, 2, 4, 8, 16, 32, 64, 128, and 256 µg ml −1 ) and DMSO vehicle (0.6%), and specific si
Journal Article
Éverton Paredes Falcão and others
Journal of Applied Microbiology, Volume 136, Issue 4, April 2025, lxaf065, https://doi.org/10.1093/jambio/lxaf065
Published: 18 April 2025
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Published: 18 April 2025
Figure 2. Microbial growth curve of the strain E. faecalis ATCC 29212 (a), MRSA NCTC13373 (b), and S. aureus NCTC 12981 (c) under the action of the 4C p C. Results presented as mean ± SD of three independent experiments performed in triplicate (one-way ANOVA with Tukey’s post-test, P  < .0001 for all
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Published: 18 April 2025
Figure 5. (a) Representative images of membrane damage assessment using PI staining of MRSA NCTC13373, Staphylococcus aureus (SA) NCTC 12981, and Enterococcus faecalis (EF) ATCC 29212 cells incubated with Van and 4C p C for 3 h of treatment. (b) Percentage of fluorescence of bacterial cells with damaged m
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Published: 18 April 2025
Figure 7. Evaluation of cell lysis by visible spectrum (OD 600nm ) of MRSA NCTC13373, Staphylococcus aureus (SA) NCTC 12981, and Enterococcus faecalis (EF) ATCC 29212 cells incubated with DMSO, Van, and 4C p C for 24 h of treatment. The assay was performed in triplicate, and data are expressed as mean ± S
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Published: 18 April 2025
Figure 8. Bacterial biofilms of MRSA NCTC13373 before and after treatment with 4C p C 27.77, 111.09, and 277.73 µmol l −1 (8, 32, and 80 µg ml −1 ) and vancomycin 1.38, 5.52, and 13.80 µmol l −1 (2, 8, and 20 µg ml −1 ), stained with AO and PI, and analyzed by CLSM. Ctrl (Untreated group).
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Published: 18 April 2025
Figure 9. Percentage of cell viability in human gingival fibroblast (HGF). HGF were treated in culture medium (M); 4C p C at 3.47, 6.94, 13.89, 27.77, 55.54, 111.09, 222.18, 444.37, and 888.73 µmol l −1 (1, 2, 4, 8, 16, 32, 64, 128, and 256 µg ml −1 ) and DMSO vehicle (0.6%). Fibroblast viability was determi
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Published: 18 April 2025
Figure 4. Inhibitory effect of 4C p C and vancomycin on MRSA NCTC 113373 biofilm. Results presented as mean ± SD of three independent experiments. All groups were compared with each other, and different letters indicate statistical difference (one-way ANOVA followed by Tukey’s post-test, P  < .05).
Journal Article
ACCEPTED MANUSCRIPT
Daniela Silva Gonçalves and others
Journal of Applied Microbiology, lxaf094, https://doi.org/10.1093/jambio/lxaf094
Published: 17 April 2025
Journal Article
ACCEPTED MANUSCRIPT
Sean D Kelly and others
Journal of Applied Microbiology, lxaf093, https://doi.org/10.1093/jambio/lxaf093
Published: 17 April 2025
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Published: 16 April 2025
Figure 2. (a) UMAP dimension reduction visualization of taxonomic profiles based on MetaPhlAn3 species abundance profiles. Color legend is shared with Fig.  2b . Axes are arbitrary and without meaningful scale. (b) NMDS visualization of Beta Diversity using the Bray–Curtis dissimilarity metric separating samp
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Published: 16 April 2025
Figure 3. (a) Relative abundance of metabolic pathways identified across all samples related to aromatic compound degradation (within the sub-class of DUA). (b) Correlation plot depicting the subset of pathways within the class of Aromatic Compound Degradation that were attributed to specific species.