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Nurgul K Bakirhan, Sıla Ozlem Sener, Merve Yuzbasioglu Baran, Khadija Bahend, Ufuk Ozgen, Electrochemical Approach on a Flavonoid: Miquelianin via Carbon Based Electrodes and Its Analysis from Calystegia Silvatica, Journal of AOAC INTERNATIONAL, 2025;, qsaf032, https://doi.org/10.1093/jaoacint/qsaf032
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Abstract
Miquelianin (MIQ) is a natural phenolic compound found in various plants, including Salvia species, with potential health benefits due to its antioxidant and anti-inflammatory properties.
This study presents the investigation of electrochemical oxidation pathway and sensitive analysis of MIQ which is isolated from the aerial parts of Calystegia silvatica that grows in Trabzon, Türkiye.
Electrochemical determination methods have gained significant attention for the quantitative analysis of bioactive compounds due to their simplicity, sensitivity, and cost-effectiveness. The electrochemical determination of MIQ primarily involves the utilization of electrochemical techniques such as cyclic voltammetry and differential pulse voltammetry.
Under optimum experimental conditions, calibration plot for MIQ with a limit of detection of 99.3 × 10−9 M and 145 × 10−9 M were obtained using differential pulse voltammetry for GCE and BDDE in the range of 2.0 × 10−6 to 3.6 × 10−5 M. The presented method was validated and successfully performed for the determination of the MIQ from plant extracts with excellent recovery values as 104.7, 101.8, and 102.1%.
This study explores the electrochemical oxidation pathway and sensitive analysis of MIQ, isolated from Calystegia silvatica in Trabzon, Türkiye. GCE and BDDE as carbon-based electrodes have been used for the sensitive analysis of MIQ in PB solution at pH 7.0 solution. MIQ was detected by GCE and BDDE with limits of 99.3 × 10−9 M and 145 × 10−9 M, respectively, within a concentration range of 2.0 × 10−6 to 3.6 × 10−5 M. The validated method demonstrated excellent recovery values of 104.7, 101.8, and 102.1% for determining MIQ from plant extracts.
This electrochemical developed method offers promising opportunities for accurate and sensitive analysis of miquelianin. Continued research and technological advancements in this field can contribute to a deeper understanding of the electrochemical behavior of miquelianin and facilitate its practical applications in pharmaceutical, food, and nutraceutical industries, promoting its utilization as a valuable bioactive compound.