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Volume 161, Issue 2
February 2017
ISSN 0021-924X
EISSN 1756-2651
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JB Special Reviews—Recent Topics in Ubiquitin-Proteasome System and Autophagy

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    COVER: Discovery in Japan. Ubiquitination is one of the protein modifications and regulates many cellular functions including signal transduction, metabolism, transcription, cell cycle, immunity and development. Ubiquitination reaction uses three types of enzymes including E1, E2 and E3, and E3 ubiquitin ligases directly recognize target proteins. Almost TRIM family proteins (approximately 70 genes in human) are E3 ubiquitin ligases (1). Dr. Shigetsugu Hatakeyama and his colleagues revealed that TRIM family proteins regulate cell growth and differentiation, carcinogenesis, innate immunity and DNA repair (2, 3).

    The cover image shows Oil Red O staining of 3T3-L1 preadipocytes after stimulation with several hormones. The differentiation to mature adipocyte of 3T3-L1 cells is evaluated by determination of lipid accumulation using Oil Red O staining. One of the TRIM family proteins, TRIM23, enhances lipid accumulation in 3T3-L1 cells via stabilization of PPARγ, indicating that TRIM23 serves as a positive regulator for adipocyte differentiation (4).


    1. Hatakeyama, S. (2011) TRIM proteins and cancer. Nat. Rev. Cancer. 11, 792–804

    2. Sato, T., Okumura, F., Ariga, T., and Hatakeyama, S. (2012) TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells. J. Cell Sci. 125, 1544–1555

    3. Masuda, Y., Takahashi, H., Sato, S., Tomomori-Sato, C., Saraf, A., Washburn, M.P., Florens, L., Conaway, R.C., Conaway, J.W., and Hatakeyama, S. (2015) TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nat. Commun. 6, 7299

    4. Watanabe, M., Takahashi, H., Saeki, Y., Ozaki, T., Itoh, S., Suzuki, M., Mizushima, W., Tanaka, K., and Hatakeyama, S. (2015) The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ. Elife. 4, e05615

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