Patient Information Page from The Hormone Foundation

Diabetes and Incretin-based Therapy

Mark E. Molitch; Guillermo Umpierrez

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La diabetes y la terapia basada en la incretina

Mark E. Molitch; Guillermo Umpierrez

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The Endocrine Society

Endocrinology & Metabolism News, April 2007

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Special Features

Approach to the Growth Hormone-Deficient Child during Transition to Adulthood

Sally Radovick; Sara DiVall

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Tags: adolescent, adult, child, persistence, hormone

Transient Hypophysitis after Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA4) Blockade

Stephanie A. Shaw; Luis H. Camacho; Ian E. McCutcheon; Steven G. Waguespack

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Tags: antigens, hypophysitis, lymphocyte

Adult Hypophosphatasia Treated with Teriparatide

Michael P. Whyte; Steven Mumm; Chad Deal

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Tags: adult, diagnostic radiologic examination, fracture, hypophosphatasia, teriparatide

Hyperandrogenism and Polycystic Ovary Syndrome in Women with Type 1 Diabetes Mellitus

Ethel Codner; Héctor F. Escobar-Morreale

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Tags: hyperandrogenism, polycystic ovary syndrome, insulin, diabetes mellitus, type 1

Current Treatment of Malignant Pheochromocytoma

Tim Scholz; Graeme Eisenhofer; Karel Pacak; Henning Dralle; Hendrik Lehnert

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Tags: 3-iodobenzylguanidine, adrenal glands, cancer, catecholamines, chemotherapy regimen

Clinical Translation of “A Diabetes Outcome Progression Trial”: ADOPT Appropriate Combination Oral Therapies in Type 2 Diabetes

Barry J. Goldstein

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Tags: diabetes mellitus, type 2

Editorials

Of the Fit and the Fat: Mitochondrial Abnormalities and Type 2 Diabetes Mellitus

Patrick Schrauwen

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Thiazolidinediones: New Evidence of Bone Loss

Ann V. Schwartz; Deborah E. Sellmeyer

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Ruling Out a Suspect: the Role of β-Catenin Mutation in Benign Parathyroid Neoplasia

William F. Simonds

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Endocrine Care

Fluorine-18-l-Dihydroxyphenylalanine (¹⁸F-DOPA) Positron Emission Tomography as a Tool to Localize an Insulinoma or β-Cell Hyperplasia in Adult Patients

Saila Kauhanen; Marko Seppänen; Heikki Minn; Risto Gullichsen; Anna Salonen ...

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Tags: adult, dihydroxyphenylalanine, fluorine, hyperplasia, insulinoma

Malignant Paragangliomas Associated with Mutations in the Succinate Dehydrogenase D Gene

B. Havekes; E. P. M. Corssmit; J. C. Jansen; A. G. L. van der Mey; A. H. J. T. Vriends ...

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Tags: catecholamines, genes, malignant paraganglionic neoplasms, mutation, paraganglioma

The Dipeptidyl Peptidase IV Inhibitor Vildagliptin Suppresses Endogenous Glucose Production and Enhances Islet Function after Single-Dose Administration in Type 2 Diabetic Patients

Bogdan Balas; Muhammad R. Baig; Catherine Watson; Beth E. Dunning; Monica Ligueros-Saylan ...

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Tags: diabetes mellitus, dipeptidyl-peptidase iv inhibitors, glucose, insulin, plasma

Relationship between Vascular Reactivity and Lipids in Mexican-Americans with Type 2 Diabetes Treated with Pioglitazone

Estela Wajcberg; Apiradee Sriwijitkamol; Nicolas Musi; Ralph A. DeFronzo; Eugenio Cersosimo

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Tags: adiponectin, diabetes mellitus, type 2, lipids, mexican americans, pioglitazone

The Influence of Selenium Supplementation on Postpartum Thyroid Status in Pregnant Women with Thyroid Peroxidase Autoantibodies

Roberto Negro; Gabriele Greco; Tiziana Mangieri; Antonio Pezzarossa; Davide Dazzi ...

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Tags: postpartum period, pregnancy, selenium, thyroid, hypothyroidism

High Plasma Level of Remnant-Like Particles Cholesterol in Familial Combined Hyperlipidemia

Jacqueline de Graaf; Gerly M. van der Vleuten; Ewoud ter Avest; Geesje M. Dallinga-Thie; Anton F. H. Stalenhoef

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Tags: cardiovascular diseases, cholesterol, plasma, hyperlipidemia, familial combined, lipoproteins

Prevalence of Permanent Neonatal Diabetes in Slovakia and Successful Replacement of Insulin with Sulfonylurea Therapy in KCNJ11 and ABCC8 Mutation Carriers

Juraj Stanik; Daniela Gasperikova; Magdalena Paskova; Lubomir Barak; Jana Javorkova ...

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Tags: insulin, mutation, neonatal diabetes mellitus, slovakia, diabetes mellitus

Annual Zoledronate Increases Bone Density in Highly Active Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Men: A Randomized Controlled Trial

Mark J. Bolland; Andrew B. Grey; Anne M. Horne; Simon E. Briggs; Mark G. Thomas ...

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Tags: bone mineral density, hiv infection, zoledronic acid, antiretroviral therapy, highly active, bone turnover rate

Endogenous Sex Hormones and Glucose Tolerance Status in Postmenopausal Women

Sherita Hill Golden; Adrian S. Dobs; Dhananjay Vaidya; Moyses Szklo; Susan Gapstur ...

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Tags: dehydroepiandrosterone, diabetes mellitus, type 2, fasting blood glucose measurement, glucose tolerance, gonadal steroid hormones

Effect of Monitoring Bone Turnover Markers on Persistence with Risedronate Treatment of Postmenopausal Osteoporosis

Pierre D. Delmas; Bernard Vrijens; Richard Eastell; Christian Roux; Huibert A. P. Pols ...

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Tags: bone turnover rate, fracture, osteoporosis, osteoporosis, postmenopausal, risedronate

The Peroxisome Proliferator-Activated Receptor-γ Agonist Rosiglitazone Decreases Bone Formation and Bone Mineral Density in Healthy Postmenopausal Women: A Randomized, Controlled Trial

Andrew Grey; Mark Bolland; Greg Gamble; Diana Wattie; Anne Horne ...

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Tags: agonists, bone mineral density, osteogenesis, peroxisome, postmenopause

Women Produce Fewer but Triglyceride-Richer Very Low-Density Lipoproteins than Men

Faidon Magkos; Bruce W. Patterson; B. Selma Mohammed; Samuel Klein; Bettina Mittendorfer

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Tags: apolipoproteins b, bodily secretions, lipoproteins, vldl, low-density lipoproteins, plasma

Association of Total Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1), and IGFBP-3 Levels with Incident Coronary Events and Ischemic Stroke

Robert C. Kaplan; Aileen P. McGinn; Michael N. Pollak; Lewis H. Kuller; Howard D. Strickler ...

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Tags: cardiovascular diseases, insulin-like growth factor binding protein 3, insulin-like growth factor i, insulin-like growth-factor binding protein 1, ischemic stroke

Announcements and Resources

Erratum

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Endocrine Care

Factors Influencing the Adrenocorticotropin Test: Role of Contemporary Cortisol Assays, Body Composition, and Oral Contraceptive Agents

Marianne Klose; Martin Lange; Aase Krogh Rasmussen; Niels Erik Skakkebæk; Linda Hilsted ...

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Tags: body composition, hydrocortisone, oral contraceptives, nephrotic syndrome, corticotropin

Androgens in Women with Anorexia Nervosa and Normal-Weight Women with Hypothalamic Amenorrhea

K. K. Miller; E. A. Lawson; V. Mathur; T. L. Wexler; E. Meenaghan ...

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Tags: androgens, anorexia nervosa, body composition, bone mineral density, hypothalamic amenorrhea

Urinary Free Cortisol: An Intermediate Phenotype and a Potential Genetic Marker for a Salt-Resistant Subset of Essential Hypertension

Bindu Chamarthi; Nikheel S. Kolatkar; Steven C. Hunt; Jonathan S. Williams; Ellen W. Seely ...

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Tags: cortisol measurement, free, urine, diet, diet, sodium-restricted, gender, genetic markers

Pharmacokinetic Factors Contribute to the Inverse Relationship between Luteinizing Hormone and Body Mass Index in Polycystic Ovarian Syndrome

Serene S. Srouji; Yanira L. Pagán; Fernando D’Amato; Amsalu Dabela; Yarisie Jimenez ...

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Tags: body mass index procedure, gonadotropin-releasing hormone, polycystic ovary syndrome, half-life, obesity

Pituitary-Gonadal Function in Adolescent Males Born Appropriate or Small for Gestational Age with or without Intrauterine Growth Restriction

Rikke Beck Jensen; Signe Vielwerth; Torben Larsen; Gorm Greisen; Johannes Veldhuis ...

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Tags: adolescent, fetal growth, fetal growth retardation, gonads, hormone

Adrenal Gland Volume and Dexamethasone-Suppressed Cortisol Correlate with Total Daily Salivary Cortisol in African-American Women

Sherita Hill Golden; Saurabh Malhotra; Gary S. Wand; Frederick L. Brancati; Daniel Ford ...

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Tags: adrenal glands, african american, dexamethasone, hydrocortisone, hypothalamic-pituitary-adrenal axis

Conditional Cardiovascular Response to Growth Hormone Therapy in Adult Patients with Prader-Willi Syndrome

Paolo Marzullo; Claudio Marcassa; Riccardo Campini; Ermanno Eleuteri; Alessandro Minocci ...

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Tags: adult, cardiovascular system, diastole, dobutamine, echocardiography

Increased Oxidative Stress in Prepubertal Children Born Small for Gestational Age

Angelika Mohn; Valentina Chiavaroli; Marina Cerruto; Annalisa Blasetti; Cosimo Giannini ...

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Tags: child, infant, small for gestational age, oxidative stress, prepuberty, antioxidants

Beneficial Effects of a Three-Month Structured Exercise Training Program on Cardiopulmonary Functional Capacity in Young Women with Polycystic Ovary Syndrome

Carlo Vigorito; Francesco Giallauria; Stefano Palomba; Teresa Cascella; Francesco Manguso ...

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Tags: exercise, functional capacity, polycystic ovary syndrome, body mass index procedure

Alendronate Prevents Bone Loss in Patients with Acute Spinal Cord Injury: A Randomized, Double-Blind, Placebo-Controlled Study

N. L. Gilchrist; C. M. Frampton; R. H. Acland; M. G. Nicholls; R. L. March ...

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Tags: alendronate, osteopenia, spinal cord injuries, calcium, hip joint

Impaired Sexual and Reproductive Outcomes in Women with Classical Forms of Congenital Adrenal Hyperplasia

F. Gastaud; C. Bouvattier; L. Duranteau; R. Brauner; E. Thibaud ...

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Tags: adolescent, child, coitus, congenital adrenal hyperplasia, female sexual function

Effect of a Mandatory Iodization Program on Thyroid Gland Volume Based on Individuals’ Age, Gender, and Preceding Severity of Dietary Iodine Deficiency: A Prospective, Population-Based Study

Pernille Vejbjerg; Nils Knudsen; Hans Perrild; Allan Carlé; Peter Laurberg ...

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Tags: goiter, iodine, iodine deficiency, thyroid, diet

Final Height Outcome after Three Years of Growth Hormone and Gonadotropin-Releasing Hormone Agonist Treatment in Short Adolescents with Relatively Early Puberty

Sandy A. van Gool; Gerdine A. Kamp; Hanneke Visser-van Balen; Dick Mul; Johan J. J. Waelkens ...

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Tags: adolescent, child, gonadotropin-releasing hormone analog, withdrawing treatment, infant, small for gestational age

Announcements and Resources

OCTOBER 9–11, 2007—San Miguel Island, Azores 8th Workshop on Resistance to Thyroid Hormone and Action

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Endocrine Care

The Effect of Sibutramine on Energy Expenditure and Body Composition in Obese Adolescents

Edgar G. A. H. Van Mil; Klaas R. Westerterp; Arnold D. M. Kester; Henriette A. Delemarre-van de Waal; Willem J. M. Gerver ...

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Tags: adolescent, body composition, body mass index procedure, energy metabolism, follow-up

Need for Additional Calcium to Reduce the Risk of Hip Fracture with Vitamin D Supplementation: Evidence from a Comparative Metaanalysis of Randomized Controlled Trials

Steven Boonen; Paul Lips; Roger Bouillon; Heike A. Bischoff-Ferrari; Dirk Vanderschueren ...

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Tags: calcium, hip fractures, meta-analysis, vitamin d, risk reduction

Assessment of Basal and Gonadotropin-Releasing Hormone-Stimulated Gonadotropins by Immunochemiluminometric and Immunofluorometric Assays in Normal Children

E. A. M. R. Resende; B. H. J. Lara; J. D. Reis; B. P. Ferreira; G. A. Pereira ...

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Tags: fluoroimmunoassay, gonadotrophin releasing hormone test, gonadotropin, gonadotropin-releasing hormone, hormone

Insulin Resistance Increases the Risk of Spontaneous Abortion after Assisted Reproduction Technology Treatment

Li Tian; Huan Shen; Qun Lu; Robert J. Norman; Jim Wang

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Tags: abortion, spontaneous, insulin resistance, polycystic ovary syndrome, obesity, reproductive techniques, assisted

Recombinant Thyrotropin in the Diagnosis of Congenital Hypothyroidism

Dov Tiosano; Lea Even; Zila Shen Orr; Ze’ev Hochberg

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Tags: child, congenital hypothyroidism, diagnosis, pharmacokinetics, radionuclide imaging

Increased Adiposity Enhances Intrafollicular Estradiol Levels in Normoandrogenic Ovulatory Women Receiving Gonadotropin-Releasing Hormone Analog/Recombinant Human Follicle-Stimulating Hormone Therapy for in Vitro Fertilization

Daniel A. Dumesic; Timothy G. Lesnick; David H. Abbott

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Tags: estradiol, fertilization in vitro, gonadotropin-releasing hormone analog, hair follicle, hormone

A 10-Year, Prospective Study of the Metabolic Effects of Growth Hormone Replacement in Adults

G. Götherström; B.-Å. Bengtsson; I. Bosæus; G. Johannsson; J. Svensson

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Tags: adult, body composition, body fat, hemoglobin a, glycosylated, insulin-like growth factor i

Other Original Articles

Amylin and Hypertension: Association of an Amylin −G132A Gene Mutation and Hypertension in Humans and Amylin-Induced Endothelium Dysfunction in Rats

Anna Novials; Leocadio Rodriguez-Mañas; Ana Chico; Mariam El Assar; Sílvia Casas ...

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Tags: endothelium, hypertension, iapp gene, mutation, rats

Thyroglobulin Gene Mutations Producing Defective Intracellular Transport of Thyroglobulin Are Associated with Increased Thyroidal Type 2 Iodothyronine Deiodinase Activity

Yasuhiko Kanou; Akira Hishinuma; Katsuhiko Tsunekawa; Koji Seki; Yutaka Mizuno ...

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Tags: iodide peroxidase, mutation, pulse, thyroglobulin, thyroid

RbAp48 is a Target of Nuclear Factor-κB Activity in Thyroid Cancer

Francesco Pacifico; Michele Paolillo; Gennaro Chiappetta; Elvira Crescenzi; Simona Arena ...

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Tags: anaplastic thyroid carcinoma, apoptosis, cell line, consensus sequence, genes

Markers of Mitochondrial Biogenesis and Metabolism Are Lower in Overweight and Obese Insulin-Resistant Subjects

Leonie K. Heilbronn; Seng Khee Gan; Nigel Turner; Lesley V. Campbell; Donald J. Chisholm

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Tags: exercise, insulin, insulin sensitivity, metabolism, mitochondria

Postprandial Lipoprotein Metabolism in Familial Hypobetalipoproteinemia

Amanda J. Hooper; Ken Robertson; P. Hugh R. Barrett; Klaus G. Parhofer; Frank M. van Bockxmeer ...

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Tags: abetalipoproteinemia, apolipoproteins b, lipoprotein metabolism, plasma, postprandial period

Protein Metabolism in Acromegaly: Differential Effects of Short- and Long-Term Treatment

James Gibney; Troels Wolthers; Morton G. Burt; Kin-Chuen Leung; A. Margot Umpleby ...

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Tags: acromegaly, leucine, oxidation, protein metabolism, protein turnover

Iodine-131 Given for Therapeutic Purposes Modulates Differently Interferon-γ-Inducible α-Chemokine CXCL10 Serum Levels in Patients with Active Graves’ Disease or Toxic Nodular Goiter

Alessandro Antonelli; Mario Rotondi; Poupak Fallahi; Mariano Grosso; Giuseppe Boni ...

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Tags: autoimmunity, chemokine, graves' disease, human leukocyte interferon, hyperthyroidism

Vitamin D Receptor Gene Haplotype Is Associated with Body Height and Bone Size

Yue Fang; Joyce B. J. van Meurs; Fernando Rivadeneira; Natasja M. van Schoor; Johannes P. T. van Leeuwen ...

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Tags: alleles, body height, genes, genotype, haplotypes

Effects of the Type 2 Diabetes-Associated PPARG P12A Polymorphism on Progression to Diabetes and Response to Troglitazone

Jose C. Florez; Kathleen A. Jablonski; Maria W. Sun; Nick Bayley; Steven E. Kahn ...

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Tags: diabetes mellitus, diabetes mellitus, type 2, genotype, polymorphism, troglitazone

Plasma Adiponectin Concentrations and Risk of Incident Breast Cancer

Shelley S. Tworoger; A. Heather Eliassen; Theodoros Kelesidis; Graham A. Colditz; Walter C. Willett ...

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Tags: adiponectin, breast cancer, national health service (uk), plasma, postmenopause

Serum Adiponectin and Bone Mineral Density in Women

J. B. Richards; A. M. Valdes; K. Burling; U. C. Perks; T. D. Spector

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Tags: adiponectin, bone mineral density, postmenopause, body mass index procedure, serum leptin measurement

Short-Term Manipulation of Plasma Free Fatty Acids Does Not Change Skeletal Muscle Concentrations of Ceramide and Glucosylceramide in Lean and Overweight Subjects

M. J. Serlie; A. J. Meijer; J. E. Groener; M. Duran; E. Endert ...

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Tags: ceramides, fatty acids, nonesterified, obesity, overweight, plasma

Altered Skeletal Muscle Fiber Composition and Size Precede Whole-Body Insulin Resistance in Young Men with Low Birth Weight

Christine B. Jensen; Heidi Storgaard; Sten Madsbad; Erik A. Richter; Allan A. Vaag

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Tags: biopsy, birth weight, blood capillaries, diabetes mellitus, type 2, glucose

Modulation of the Homocysteine-Betaine Relationship by Methylenetetrahydrofolate Reductase 677 C->T Genotypes and B-Vitamin Status in a Large-Scale Epidemiological Study

Pål I. Holm; Steinar Hustad; Per Magne Ueland; Stein Emil Vollset; Tom Grotmol ...

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Tags: betaine, folic acid, genotype, homocysteine, methylenetetrahydrofolate reductase (nadph2)

A Familial Insulin-Like Growth Factor-I Receptor Mutant Leads to Short Stature: Clinical and Biochemical Characterization

Kenjiro Inagaki; Anatoly Tiulpakov; Petr Rubtsov; Polina Sverdlova; Valentina Peterkova ...

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Tags: cell proliferation, fibroblast, insulin-like growth factor i, insulin-like-growth factor i receptor, mutation

Adiponectin Levels in Prepubertal Children with Prader-Willi Syndrome before and during Growth Hormone Therapy

D. A. M. Festen; A. van Toorenenbergen; H. J. Duivenvoorden; A. C. S. Hokken-Koelega

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Tags: adiponectin, body composition, child, insulin, prader-willi syndrome

Human Adipose Tissue Cannabinoid Receptor 1 Gene Expression Is Not Related to Fat Cell Function or Adiponectin Level

Patrik Löfgren; Eva Sjölin; Kerstin Wåhlen; Johan Hoffstedt

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Tags: adipocytes, adiponectin, adipose tissue, cannabinoid receptor, gene expression

Sympathetic Vasomotor Tone Determines Blood Pressure Response to Long-Term Sibutramine Treatment

Karsten Heusser; Stefan Engeli; Jens Tank; Andre Diedrich; Susanne Wiesner ...

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Tags: blood pressure, sibutramine, plasma, catecholamines, adrenergic receptor

Absence of Stabilizing Mutations of β-Catenin Encoded by CTNNB1 Exon 3 in a Large Series of Sporadic Parathyroid Adenomas

Jessica Costa-Guda; Andrew Arnold

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Tags: beta catenin, exons, mutation, parathyroid adenoma, neoplasms

Announcements and Resources

Endocrine-Related Resources from the National Institutes of Health

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National Hormone & Peptide Program (NHPP): New Recombinant Hormones, Hypothalamic Peptides, Natural Hormones, New Antisera, & Expanded Hormone Assay Services Available

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