Volume 93 Issue 4 | The Journal of Clinical Endocrinology & Metabolism

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Patient Information Page from The Hormone Foundation

The Hormone Foundation’s Patient Guide to the Evaluation and Treatment of Hirsutism in Premenopausal Women

Jeffrey Chang; Kathryn A. Martin; Robert A. Vigersky

The Endocrine Society

Endocrinology & Metabolism News, April 2008

Special Features

Update on the Molecular Diagnosis of Endocrine Tumors: Toward –omics-Based Personalized Healthcare?

Frank Weber; Charis Eng

Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline

Kathryn A. Martin; R. Jeffrey Chang; David A. Ehrmann; Lourdes Ibanez; Rogerio A. Lobo ...

Massive Soft Tissue Calcifications and Cinacalcet

Simona Zerbi; Pio Ruggiero; Luciano A. Pedrini

Insulinoma and Gastrinoma Syndromes from a Single Intrapancreatic Neuroendocrine Tumor

Maya B. Lodish; Anathea C. Powell; Mones Abu-Asab; Craig Cochran; Petra Lenz ...

Association of a Homozygous Nonsense Caveolin-1 Mutation with Berardinelli-Seip Congenital Lipodystrophy

C. A. Kim; Marc Delépine; Emilie Boutet; Haquima El Mourabit; Soazig Le Lay ...

Insulin Sensitizers for the Treatment of Hirsutism: A Systematic Review and Metaanalyses of Randomized Controlled Trials

Mihaela Cosma; Brian A. Swiglo; David N. Flynn; David M. Kurtz; Matthew L. LaBella ...

Tags: hirsutism, insulin sensitizer, metformin, thiazolidinedione

The Role of Advanced Glycation End Products in Progression and Complications of Diabetes

Su-Yen Goh; Mark E. Cooper

Tags: age, diabetes mellitus, diabetes mellitus, type 2, rage, complications of diabetes mellitus

Antiandrogens for the Treatment of Hirsutism: A Systematic Review and Metaanalyses of Randomized Controlled Trials

Brian A. Swiglo; Mihaela Cosma; David N. Flynn; David M. Kurtz; Matthew L. LaBella ...

Tags: androgen antagonists, hirsutism, metformin

Piecing the Puzzle Together: ACCORDing to Whom?

Irl B. Hirsch

Tags: cardiovascular diseases, cardiovascular event, diabetes mellitus, type 2, glucose control, dcct trial

The United States Endocrinology Workforce: A Supply-Demand Mismatch

Andrew F. Stewart

Tags: endocrinologists, endocrinology, mismatch, workforce, diabetes mellitus

Thyrotropin Suppressive Therapy in Thyroid Carcinoma: What Are the Targets?

G. Brabant

Tags: thyroid carcinoma, thyrotropin

Editorials

Do Cardiovascular Risk Factors in Polycystic Ovarian Syndrome Result in More Cardiovascular Events?

David S. Guzick

Thyroid Hormone Treatment to Mend a Broken Heart

Irwin Klein; Sara Danzi

Reproductive Hormones and Skeletal Health in Young Women

Susan M. Ott

Whole-Body Dual-Energy X-Ray Absorptiometry Comes of Age: Bone Structural Measures and Their Physiological Determinants in Anorexia Nervosa

Richard L. Prince; Kun Zhu

Should We Still Use Glucose-Suppressed Growth Hormone Levels for the Evaluation of Acromegaly?

Annamaria Colao; Gaetano Lombardi

Caveolin-1: A New Locus for Human Lipodystrophy

Abhimanyu Garg; Anil K. Agarwal

Endocrine Care

Onset of Ovulation after Menarche in Girls: A Longitudinal Study

Katie Zhang; Staci Pollack; Ali Ghods; Carrie Dicken; Barbara Isaac ...

Tags: adult, hormone, menarche, menstruation, ovulation

Evaluation of Gene Expression Profiles in Thyroid Nodule Biopsy Material to Diagnose Thyroid Cancer

Stéphanie Durand; Carole Ferraro-Peyret; Samia Selmi-Ruby; Christian Paulin; Michelle El Atifi ...

Tags: biopsy, cancer, diagnosis, gene expression, gene expression profiling

Selective Loss of Somatostatin Receptor 2 in Octreotide-Resistant Growth Hormone-Secreting Adenomas

Ursula Plöckinger; Susann Albrecht; Christian Mawrin; Wolfgang Saeger; Michael Buchfelder ...

Tags: adenoma, neoplasms, octreotide, somatostatin receptor, antibodies

Low Levels of Raf Kinase Inhibitory Protein in Growth Hormone-Secreting Pituitary Adenomas Correlate with Poor Response to Octreotide Treatment

Stine Lyngvi Fougner; Jens Bollerslev; Fahim Latif; John K. Hald; Terje Lund ...

Tags: adenoma, octreotide, pebp1 gene, phosphotransferases, western blotting

Effect of Vitamin K Supplementation on Bone Loss in Elderly Men and Women

Sarah L. Booth; Gerard Dallal; M. Kyla Shea; Caren Gundberg; James W. Peterson ...

Tags: calcium, diet, elderly, neck of femur, osteopenia

Thyrotropin Levels in a Population with No Clinical, Autoantibody, or Ultrasonographic Evidence of Thyroid Disease: Implications for the Diagnosis of Subclinical Hypothyroidism

Thomas E. Hamilton; Scott Davis; Lynn Onstad; Kenneth J. Kopecky

Tags: diagnosis, subclinical hypothyroidism, thyroid diseases, thyrotropin, ultrasonography

Weight Gain and Restoration of Menses as Predictors of Bone Mineral Density Change in Adolescent Girls with Anorexia Nervosa-1

Madhusmita Misra; Rajani Prabhakaran; Karen K. Miller; Mark A. Goldstein; Diane Mickley ...

Tags: adolescent, anorexia nervosa, bone mineral density, menstruation, weight gain

Growth Hormone Treatment of Adults with Prader-Willi Syndrome and Growth Hormone Deficiency Improves Lean Body Mass, Fractional Body Fat, and Serum Triiodothyronine without Glucose Impairment: Results from the United States Multicenter Trial

Harriette R. Mogul; Phillip D. K. Lee; Barbara Y. Whitman; William B. Zipf; Michael Frey ...

Tags: adult, body composition, glucose, lean body mass, prader-willi syndrome

Elevated Cocaine- and Amphetamine-Regulated Transcript Immunoreactivity in the Circulation of Patients with Neuroendocrine Malignancy

Paul Bech; Virginia Winstanley; Kevin G. Murphy; Amir H. Sam; Karim Meeran ...

Tags: amphetamine, cancer, chromatography, chromogranin a, cocaine

Growth Hormone Response during Oral Glucose Tolerance Test: The Impact of Assay Method on the Estimation of Reference Values in Patients with Acromegaly and in Healthy Controls, and the Role of Gender, Age, and Body Mass Index

Ayman M. Arafat; Matthias Möhlig; Martin O. Weickert; Frank H. Perschel; Johannes Purschwitz ...

Tags: acromegaly, body mass index procedure, diagnosis, gender, laboratory

High Serum Inhibin Concentration Discriminates Autoimmune Oophoritis from Other Forms of Primary Ovarian Insufficiency

Anastasia Tsigkou; Stefania Marzotti; Lavinia Borges; Annalisa Brozzetti; Fernando Reis ...

Tags: autoimmune oophoritis, autoimmunity, inhibin, inhibin b, turner's syndrome

Urinary Cortisol and Catecholamine Excretion after Burn Injury in Children

William B. Norbury; David N. Herndon; Ludwik K. Branski; David L. Chinkes; Marc G. Jeschke

Tags: burns, catecholamines, child, hydrocortisone, urinary tract

Withdrawn: Postmenopausal Women with a History of Irregular Menses and Elevated Androgen Measurements at High Risk for Worsening Cardiovascular Event-Free Survival: Results from the National Institutes of Health—National Heart, Lung, and Blood Institute Sponsored Women’s Ischemia Syndrome Evaluation

Leslee J. Shaw; C. Noel Bairey Merz; Ricardo Azziz; Frank Z. Stanczyk; George Sopko ...

Tags: angiogram, cardiovascular event, cardiovascular system, heart, lung

Abdominal Obesity in Older Women: Potential Role for Disrupted Fatty Acid Reesterification in Insulin Resistance

Catherine W. Yeckel; James Dziura; Loretta DiPietro

Tags: abdomen, abdominal circumference, adipose tissue, elderly, fatty acids

Prognostic Indicators of Changes in Bone Density Measures in Adolescent Girls with Anorexia Nervosa-II

Madhusmita Misra; Rajani Prabhakaran; Karen K. Miller; Mark A. Goldstein; Diane Mickley ...

Tags: adolescent, anorexia nervosa, bone mineral density, ghrelin, hydrocortisone

3α-Hydroxysteroid Dehydrogenase Type III Deficiency: A Novel Mechanism for Hirsutism

Anne Z. Steiner; Lilly Chang; Qing Ji; Murad Ookhtens; Andrew Stolz ...

Tags: androgens, genital system, hirsutism, hydroxysteroids, metabolism

Androgen Receptor Gene CAG Repeat Polymorphism and X-Chromosome Inactivation in Children with Premature Adrenarche

Saila Lappalainen; Pauliina Utriainen; Tiina Kuulasmaa; Raimo Voutilainen; Jarmo Jääskeläinen

Tags: androgen receptor, body mass index procedure, child, genes, polymorphism

A Functional Anti-Müllerian Hormone Gene Polymorphism Is Associated with Follicle Number and Androgen Levels in Polycystic Ovary Syndrome Patients

Marlies E. Kevenaar; Joop S. E. Laven; Sharon Lie Fong; André G. Uitterlinden; Frank H. de Jong ...

Tags: androgens measurement, hair follicle, hormone, isoleucine, mullerian-inhibiting hormone

Effects of Depot Medroxyprogesterone Acetate on Bone Density and Bone Metabolism before and after Peak Bone Mass: A Case-Control Study

Jennifer S. Walsh; Richard Eastell; Nicola F. A. Peel

Tags: bone mineral density, medroxyprogesterone acetate, bone turnover rate, hip joint, hip region

Divergence between Growth Hormone and Insulin-Like Growth Factor-I Concentrations in the Follow-Up of Acromegaly

Orsalia Alexopoulou; Marie Bex; Roger Abs; Guy T’Sjoen; Brigitte Velkeniers ...

Tags: acromegaly, insulin-like growth factor i

Associations of Insulin-Like Growth Factor (IGF)-I, IGF-II, IGF Binding Protein (IGFBP)-2 and IGFBP-3 with Ultrasound Measures of Atherosclerosis and Plaque Stability in an Older Adult Population

Richard M. Martin; David Gunnell; Elise Whitley; Andrew Nicolaides; Maura Griffin ...

Tags: atherosclerosis, igfbp2 protein, human, insulin-like growth factor binding protein 3, insulin-like growth factor i, insulin-like growth factor ii

Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin

Christian Benedict; Werner Kern; Bernd Schultes; Jan Born; Manfred Hallschmid

Tags: eating, insulin, memory, hippocampus (brain), brain

Post-Meal Glucose Peaks at Home Associate with Carotid Intima-Media Thickness in Type 2 Diabetes

Katherine Esposito; Miryam Ciotola; Diego Carleo; Bruno Schisano; Luigi Sardelli ...

Tags: carotid intima-media thickness, diabetes mellitus, diabetes mellitus, type 2, glucose, hemoglobin a, glycosylated

Acute Effects of Triiodothyronine (T₃) Replacement Therapy in Patients with Chronic Heart Failure and Low-T₃ Syndrome: A Randomized, Placebo-Controlled Study

Alessandro Pingitore; Elena Galli; Andrea Barison; Annalisa Iervasi; Maria Scarlattini ...

Tags: aldosterone, cardiac mri, diastole, heart failure, chronic, heart ventricle

Factors Predicting the Near-Final Height in Growth Hormone-Treated Children and Adolescents with Chronic Kidney Disease

Richard Nissel; Anders Lindberg; Otto Mehls; Dieter Haffner; on behalf of the Pfizer International Growth Database (KIGS) International Board

Tags: conservative treatment, hemodialysis, kidney failure, chronic, prepuberty, puberty

Roles of Clinical Criteria, Computed Tomography Scan, and Adrenal Vein Sampling in Differential Diagnosis of Primary Aldosteronism Subtypes

Paolo Mulatero; Chiara Bertello; Denis Rossato; Giulio Mengozzi; Alberto Milan ...

Tags: adrenal glands, aldosterone, computed tomography, conn adenoma, diagnosis

Association between the Metabolic Syndrome and Serum Cortisol in Overweight Latino Youth

Marc J. Weigensberg; Claudia M. Toledo-Corral; Michael I. Goran

Tags: child, hispanics or latinos, hydrocortisone, insulin sensitivity, metabolic syndrome x

Growth Hormone Exerts Acute Vascular Effects Independent of Systemic or Muscle Insulin-like Growth Factor I

Guolian Li; Juan-Pablo del Rincon; Linda A. Jahn; Yangsong Wu; Bruce Gaylinn ...

Tags: forearm, infusion procedures, insulin-like growth factor i, nitric oxide synthase, phosphorylation

Normal Growth and Muscle Dysfunction in X-Linked Hypophosphatemic Rickets Associated with a Novel Mutation in the PHEX Gene

Polyzois Makras; Neveen A. T. Hamdy; Sarina G. Kant; Socrates E. Papapoulos

Tags: familial hypophosphatemic bone disease, genes, mothers, mutation, myopathy

TFF3-Based Candidate Gene Discrimination of Benign and Malignant Thyroid Tumors in a Region with Borderline Iodine Deficiency

Kerstin Krause; Markus Eszlinger; Oliver Gimm; Stefan Karger; Cornelia Engelhardt ...

Tags: candidate disease gene, galectin 3, genes, iodine deficiency, malignant neoplasm of thyroid

The Complex Relationship between Hypothalamic Amenorrhea and Polycystic Ovary Syndrome

Jeff G. Wang; Rogerio A. Lobo

Tags: hypothalamic amenorrhea, polycystic ovary syndrome, gonadotropin, hyperandrogenism, androgens

Failure to Detect Measles Virus Ribonucleic Acid in Bone Cells from Patients with Paget’s Disease

Brya G. Matthews; Muhammad A. Afzal; Philip D. Minor; Usha Bava; Karen E. Callon ...

Tags: measles virus, osteitis deformans, polymerase chain reaction, rna, osteoblasts

The Endocrine Phenotype in Silver-Russell Syndrome Is Defined by the Underlying Epigenetic Alteration

Gerhard Binder; Ann-Kathrin Seidel; David D. Martin; Roland Schweizer; C. Philipp Schwarze ...

Tags: 11p15, child, epigenetics, infant, small for gestational age, insulin-like growth factor binding protein 3

Prevalence of Polycystic Ovary Syndrome and Hyperandrogenemia in Female-to-Male Transsexuals

Andreas Mueller; Louis J. Gooren; Susanne Naton-Schötz; Susanne Cupisti; Matthias W. Beckmann ...

Tags: hyperandrogenemia, polycystic ovary syndrome, united states national institutes of health, hyperandrogenism, diagnosis

Correlation of in Vitro and in Vivo Somatotropic Adenoma Responsiveness to Somatostatin Analogs and Dopamine Agonists with Immunohistochemical Evaluation of Somatostatin and Dopamine Receptors and Electron Microscopy

Diego Ferone; Wouter W. de Herder; Rosario Pivonello; Johan M. Kros; Peter M. van Koetsveld ...

Tags: adenoma, dopamine agonists, dopamine receptor, immunohistochemistry, insulin-like growth factor i

Endocrine Research

Carboxyl-Terminal Mutations in 3β-Hydroxysteroid Dehydrogenase Type II Cause Severe Salt-Wasting Congenital Adrenal Hyperplasia

Maik Welzel; Nele Wüstemann; Gunter Ŝimić-Schleicher; Helmuth G. Dörr; Egbert Schulze ...

Tags: cachexia, congenital adrenal hyperplasia, dehydroepiandrosterone, hydroxysteroids, mutation

Analysis of the GCM2 Gene in Isolated Hypoparathyroidism: A Molecular and Biochemical Study

Alexander Maret; Changlin Ding; Sara Levine Kornfield; Michael A. Levine

Tags: alleles, dna, exons, genes, hypoparathyroidism

Activation of Peroxisome Proliferator-Activated Receptor Pathway Stimulates the Mitochondrial Respiratory Chain and Can Correct Deficiencies in Patients’ Cells Lacking Its Components

Jean Bastin; Flore Aubey; Agnès Rötig; Arnold Munnich; Fatima Djouadi

Tags: bezafibrate, enzymes, genes, mitochondria, peroxisome proliferator-activated receptors

Evaluation of Telomere Length Maintenance Mechanisms in Adrenocortical Carcinoma

Tobias Else; Thomas J. Giordano; Gary D. Hammer

Tags: adrenocortical carcinoma, diagnosis, telomerase, telomere, telomere maintenance

Regional Brain Activation during Hypoglycemia in Type 1 Diabetes

Gail Musen; Donald C. Simonson; Nicolas R. Bolo; Amy Driscoll; Katie Weinger ...

Tags: brain, brain activity, diabetes mellitus, glucose, hypoglycemia

Akt Phosphorylation in Lymphocytes Provides an Index of in Vitro Insulin-Like Growth Factor I Sensitivity Associated with Growth Hormone-Induced Growth

Chantal Lotton; Danielle Rodrigue; Caroline Elie; Anya Rothenbühler; Najiba Lahlou ...

Tags: insulin-like growth factor i, lymphocyte, phosphorylation, proto-oncogene proteins c-akt, child

Elevated Serum Levels of Estradiol, Dihydrotestosterone, and Inhibin B in Adult Males Born Small for Gestational Age

K. Allvin; C. Ankarberg-Lindgren; H. Fors; J. Dahlgren

Tags: adult, estradiol, infant, small for gestational age, inhibin b, stanolone

Plasma α-Defensin Is Associated with Cardiovascular Morbidity and Mortality in Type 1 Diabetic Patients

Gowsini Joseph; Lise Tarnow; Anne Sofie Astrup; Troels Krarup Hansen; Hans-Henrik Parving ...

Tags: cardiovascular diseases, defensins, morbidity, mortality, plasma

Ghrelin Inhibits Steroid Biosynthesis by Cultured Granulosa-Lutein Cells

Isabella Viani; Alessandra Vottero; Francesco Tassi; Giulia Cremonini; Chiara Sartori ...

Tags: ghrelin, lutein, steroidogenesis

High Levels of Inflammatory Biomarkers Are Associated with Increased Allele-Specific Apolipoprotein(a) Levels in African-Americans

Erdembileg Anuurad; Jill Rubin; Alan Chiem; Russell P. Tracy; Thomas A. Pearson ...

Tags: african american, alleles, apolipoproteins, fibrinogen, whites

Prognostic Value of Adiponectin for Cardiovascular Disease and Mortality

Jacqueline M. Dekker; Tohru Funahashi; Giel Nijpels; Stefan Pilz; Coen D. A. Stehouwer ...

Tags: adiponectin, cardiovascular diseases, mortality, cardiovascular disease risk factors, morbidity

Variations in PPARD Determine the Change in Body Composition during Lifestyle Intervention: A Whole-Body Magnetic Resonance Study

Claus Thamer; Jürgen Machann; Norbert Stefan; Silke A. Schäfer; Fausto Machicao ...

Tags: adipose tissue, body composition, diabetes mellitus, type 2, insulin sensitivity, life style

The Association between the FTO Gene and Fat Mass in Humans Develops by the Postnatal Age of Two Weeks

Abel López-Bermejo; Clive J. Petry; Marta Díaz; Giorgia Sebastiani; Francis de Zegher ...

Tags: abdomen, fto gene, newborn, single nucleotide polymorphism, birth weight

Announcements and Resources

Erratum

Endocrine-Related Resources from the National Institutes of Health

National Hormone & Peptide Program (NHPP): New Recombinant Hormones, Hypothalamic Peptides, Natural Hormones, New Antisera, & Expanded Hormone Assay Services Available

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