Immunologic Memory 5 Years after Meningococcal A/C Conjugate Vaccination in Infancy

Abstract

Infant vaccination with meningococcal conjugates may provide long-term protection against disease. Antibody levels and immunologic memory were assessed in 5-year-old Gambian children who received meningococcal A/C conjugate vaccination (MenA/C) in infancy. At 2 years, they were randomized to receive a booster of MenA/C (conjugate group), meningococcal A/C polysaccharide (MPS group), or inactivated polio vaccine (IPV group). All groups were revaccinated with 10 µg MPS at 5 years of age, as were 39 previously unvaccinated agematched control subjects. Before revaccination, titers were higher in the conjugate and MPS groups than in control subjects (P < .001); titers for the IPV group were similar to those for control subjects. Ten days after revaccination, the conjugate and IPV groups had similar serogroup C serum bactericidal antibody titers (3421 vs. 2790, respectively). These levels were significantly higher than those in the MPS (426) and control (485) groups (P < .001). Thus, immunologie memory was sustained for ⩾5 years; however, MPS challenge at 2 years interfered with a subsequent memory response.