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Volume 9, Issue 1
February 2017
ISSN 1674-2788
EISSN 1759-4685
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p53 and MDM2: Their Yin-Yang Intimacy

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    Cover: The tangled and intimate relationship between evolutionarily conserved MDM2 and p53, analogized by the fine balance of Yin (p53) and Yang (MDM2) in a negative feedback regulatory axis, is essentially important for embryogenesis, stem cell renewal, organogenesis, adult homeostasis, genomic stability, and cancer development in the animal kingdom including humans. If off balance, on one hand, cancer develops due to the inactivation of p53 by MDM2 or other oncogenes, such as MDMX, and on the other hand, aberrant development occurs as a result of abnormally activated p53 caused by loss or inactivation of MDM2 or MDMX. Hence, a fine balance is required for normal life, i.e. higher eukaryotic cells to proliferate and grow happily, embryos to develop normally, specific organs to form correctly, and animals to live healthily. See pages 1–2 by Lu for details.

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