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Explore our collection of all-time top-scoring Altmetric articles from the Journal of Molecular Cell Biology

Generation of gene-target dogs using CRISPR/Cas9 system
Qingjian Zou, Xiaomin Wang, Yunzhong Liu, Zhen Ouyang, Haibin Long, Shu Wei, Jige Xin, Bentian Zhao, Sisi Lai, Jun Shen, Qingchun Ni, Huaqiang Yang, Huilin Zhong, Li Li, Minhua Hu, Quanjun Zhang, Zhidong Zhou, Jiaxin He, Quanmei Yan, Nana Fan, Yu Zhao, Zhaoming Liu, Lin Guo, Jiao Huang, Guanguan Zhang, Jun Ying, Liangxue Lai, and Xiang Gao 

Hypoxia and miscoupling between reduced energy efficiency and signaling to cell proliferation drive cancer to grow increasingly faster
Juan Cui, Xizeng Mao, Victor Olman, P. J. Hastings, and Ying Xu

A key role for PTP1B in dendritic cell maturation, migration, and T cell activation
Cristina Martin-Granados, Alan R. Prescott, Samantha Le Sommer, Izabela P. Klaska, Tian Yu, Elizabeth Muckersie, Claudiu V. Giuraniuc, Louise Grant, Mirela Delibegovic, and John V. Forrester

Okazaki fragment maturation: nucleases take centre stage
Li Zheng and Binghui Shen 

The lysosome: from waste bag to potential therapeutic target
Hanna Appelqvist, Petra Wäster, Katarina Kågedal, and Karin Öllinger 

Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1
Rong Wang, Zhijing Wang, Kaikai Wang, Tianlong Zhang, and Jianping Ding 

Integrative analyses of RNA editing, alternative splicing, and expression of young genes in human brain transcriptome by deep RNA sequencing
Dong-Dong Wu, Ling-Qun Ye, Yan Li, Yan-Bo Sun, Yi Shao, Chunyan Chen, Zhu Zhu, Li Zhong, Lu Wang, David M. Irwin, Yong E. Zhang, and Ya-Ping Zhang

DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage
Laura Zannini, Giacomo Buscemi, Ja-Eun Kim, Enrico Fontanella, and Domenico Delia 

Hot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation
Nickolai A. Tchurikov, Daria M. Fedoseeva, Dmitri V. Sosin, Anastasia V. Snezhkina, Nataliya V. Melnikova, Anna V. Kudryavtseva, Yuri V. Kravatsky, and Olga V. Kretova 

Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives
Ori Bar-Nur, Inbal Caspi, and Nissim Benvenisty
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