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Research Article
Predictive role of CD36 expression in HER2-positive breast cancer patients receiving neoadjuvant trastuzumab
Francesca Ligorio, MD et al.
Background Despite huge efforts to identify biomarkers associated with long-term clinical outcomes in patients with early-stage Human Epidermal growth factor Receptor 2 (HER2)-positive Breast Cancer (HER2+ BC) treated with (neo)adjuvant anti-HER2 therapy, no reliable predictors have been identified so far. Fatty Acid uptake, a process mediated by the transmembrane transporter CD36, has recently ...
Research Article
Radiotherapy-related dose and irradiated volume effects on breast cancer risk among Hodgkin lymphoma survivors
Sander Roberti, MSc et al.
Background Breast cancer (BC) risk is increased among Hodgkin lymphoma (HL) survivors treated with chest radiotherapy. Case-control studies showed a linear radiation dose-response relationship for estimated dose to the breast tumor location. However, these relative risks cannot be used for absolute risk prediction of BC anywhere in the breasts. Furthermore, the independent and joint effects of ...
Editorial
Can breast cancer prevention strategies be tailored to biologic subtype and unique reproductive windows?
Pepper Schedin, PhD, Julie R Palmer, ScD
Research Article
Distinct reproductive risk profiles for intrinsic-like breast cancer subtypes: pooled analysis of population-based studies
Audrey Y Jung, PhD et al.
Background Reproductive factors have been shown to be differentially associated with risk of estrogen receptor (ER) positive and ER-negative breast cancer. However, their associations with intrinsic-like subtypes are less clear. Methods Analyses included up to 23,353 cases, and 71,072 controls pooled from 31 population-based case-control or cohort studies in the Breast Cancer Association ...
Correction
Correction to: Nitrogen-based Bisphosphonate Use and Ovarian Cancer Risk in Women Aged 50 Years and Older
This is a correction to: Karen M Tuesley, MEPI, Penelope M Webb, DPhil, Melinda M Protani, PhD, Katrina Spilsbury, PhD, Sallie-Anne Pearson, PhD, Michael D Coory, PhD, Peter Donovan, MBBS, Christopher Steer, MBBS, Louise M Stewart, PhD, Nirmala Pandeya, PhD, Susan J Jordan, PhD, Nitrogen-based Bisphosphonate Use and Ovarian Cancer Risk in Women Aged 50 Years and Older, JNCI: Journal of the ...

Editor's Choice & Editorials

Editorials
Do Cell Phones Cause Brain Tumors? Another Piece of the Puzzle
Douglas L Weed, MD, MPH, PhD
JNCI: Journal of the National Cancer Institute, Volume 114, Issue 5, May 2022, Pages 643–644, https://doi.org/10.1093/jnci/djac043
—You can’t blow an uncertain trumpet. Reverend Theodore Hesburgh,  Time magazine No greater puzzle exists in epidemiology than trying to determine what causes diseases like cancer. It is a puzzle with metaphysical roots that can be traced back to the ancient Greeks. And it is a puzzle with great complexity that tests our ingenuity and skill. We work so hard to solve it because its solutions can ...
Editorials
Room to Grow: The Need for Cancer Site–Specific Research Into Biomarkers of Aging and Immunity in People With HIV
Anna E Coghill, PhD, MPH, Brittney L Dickey, PhD, MPH
JNCI: Journal of the National Cancer Institute, Volume 114, Issue 6, June 2022, Pages 790–791, https://doi.org/10.1093/jnci/djac056
HIV and cancer have been inextricably linked since the beginning of the HIV epidemic in the United States. The unexpected clustering of Kaposi sarcoma (KS) diagnoses was one of the first pieces of evidence that a new epidemic was emerging ( 1 ). Immunosuppression resulting from HIV-mediated depletion of host CD4+ T cells impairs the ability of people with HIV (PWH) to control infections, ...
Editor's Choice Articles
Enduring Cancer Disparities by Persistent Poverty, Rurality, and Race: 1990-1992 to 2014-2018
Jennifer L Moss, PhD et al.
JNCI: Journal of the National Cancer Institute, Volume 114, Issue 6, June 2022, Pages 829–836, https://doi.org/10.1093/jnci/djac038
Background Most persistent poverty counties are rural and contain high concentrations of racial minorities. Cancer mortality across persistent poverty, rurality, and race is understudied. Methods We gathered data on race and cancer deaths (all sites, lung and bronchus, colorectal, liver and intrahepatic bile duct, oropharyngeal, breast and cervical [females], and prostate [males]) from the ...
Editorials
How Can We Pursue Equity in Cervical Cancer Prevention With Existing HPV Genotype Differences?
Sarah P Huepenbecker, MD, Larissa A Meyer, MD, MPH
JNCI: Journal of the National Cancer Institute, Volume 114, Issue 6, June 2022, Pages 787–789, https://doi.org/10.1093/jnci/djac035
Persistent infection with high-risk human papillomavirus (HPV) is the cause of most cervical cancers ( 1 , 2 ). Over the past decades, there has been significant progress in primary and secondary prevention of cervical cancer through HPV vaccination and screening. The first HPV vaccines approved for use in the United States targeted the most common oncogenic genotypes, HPV16 and HPV18 ( 3 , 4 ), ...
Editorials
The Unrelenting Impact of Poverty on Cancer: Structural Inequities Call for Research and Solutions on Structural Determinants
Scarlett Lin Gomez, PhD et al.
JNCI: Journal of the National Cancer Institute, Volume 114, Issue 6, June 2022, Pages 783–784, https://doi.org/10.1093/jnci/djac040
Over the past several years, there has been greater appreciation for the impact of structural and contextual factors on disease outcomes, including cancer ( 1 , 2 ). Given that these structural and contextual factors are distributed inequitably across population groups, there is also increased attention and research focused on understanding how these factors produce and sustain health inequities ...

Opioids and Cancer Collection

Explore a selection of articles from JNCI and JNCI Cancer Spectrum on opioid use in cancer patients and survivors. 

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Colorectal Cancer Collection

JNCI and JNCI Cancer Spectrum have collated a collection of some of the best papers on colorectal cancer published by both journals in recent years.

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COVID-19 Collection

JNCI and JNCI Cancer Spectrum have published a number of peer-reviewed, cancer-relevant manuscripts related to the pandemic. Explore the freely available articles in this collection.  

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JNCI Collections

Read specially curated collections of articles from JNCI and JNCI Cancer Spectrum on timely topics related to cancer. Collections include the top articles in the field identified by the JNCI editors.

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JNCI Cancer Spectrum

JNCI Cancer Spectrum is a peer-reviewed, open-access journal that publishes 6 issues per year online. The journal publishes manuscripts that describe new findings of particular significance across a full range of clinical and translational cancer research, including prevention, screening, and treatment, as well as clinically relevant epidemiologic, public health, and policy research.

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