Genetic Variation at 9p22.2 and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers

Affiliation of authors: Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London, UK (SJR, SAG); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (CK, LM, SP, MC, CO, DF, ACA); Cancer Research United Kingdom Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (PDPP); Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (OMS); Queensland Institute of Medical Research, Brisbane, Queensland, Australia (JBee, XC, SHe, ABS, HH, GC-T); Department of Laboratory Medicine and Pathology (FJC, XW) and Department of Health Sciences Research (ZF), Mayo Clinic, Rochester, MN; Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy (PP, PR); Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy (SMa, BP, DZ, GR); Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy (MB); Division of Experimental Oncology 1, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy (AV); Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy (AA); Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy (LO); Medical Genetics Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy (LP); Department of Epidemiology and Prevention, IRCCS Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy (VG); Cogentech, Consortium for Genomics Technology, Milan, Italy (FC); Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (MHG, PLM); Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (ILA); Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada (GG); Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (HO); Clinical Genetics, Odense University Hospital, Odense, Denmark (MT, TAK, A-MG); Clinical Genetics, Rigshospital Copenhagen, Denmark (A-MG); Clinical Genetics, Vejle Hospital, Vejle, Denmark (DC); Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark (UBJ); Section of Genetic Oncology, Department of Oncology, University Hospital of Pisa, Pisa, Italy (MAC); Department of Oncology (HO, AB) and Department of Clinical Genetics (UK), Lund University, Lund, Sweden; Department of Clinical Genetics (AL) and Department of Oncology (BA), Karolinska University Hospital, Stockholm, Sweden; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden (PK); Department of Oncology, Linköping University Hospital, Linköping, Sweden (MSA); Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA (SLN, YCD), Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA (KLN, SMD); International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland ( AJ, JL, TH, TB, JGron, BG, CCy, TD); Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (AO); Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain (MD); Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain (M-IT); Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (JB); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (UH); Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (MAR); Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands (SV); Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands (MAT-L); Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands (MPV, CJA); DNA Diagnostics, Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (DB); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (MGEMA); Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands (TAvO); Department of Clinical Genetics, University Hospital Maastricht, Maastricht, the Netherlands (MJB); Department of Clinical Genetics, VU Medical Center, Amsterdam, the Netherlands (HEJM-H); Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK (AMD); Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK (DGE); Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK (RE); Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK (GP); West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK (TCo); Clinical Genetics Department, St George's Hospital, University of London, London, UK (SH); Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK (CB); Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, UK (PJM ); South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK (MP); Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire (MJK); All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK (MTR); North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK (LES);Clinical Genetics Department, St Michael's Hospital, Bristol, UK (AD); North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Aberdeen, UK (HG); Women's Cancer Program, Departrment of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA ( AKG, MBD); INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France (DS-L, VM, LC); Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (SM, LB); CNRS UMR5558, Université Lyon 1, and Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France (VB); Department of Genetics, Centre Hospitalier Universitaire de Grenoble, and Institut Albert Bonniot, Université de Grenoble, Grenoble, France (DL); Centre de Génétique, Centre Hospitalier Universitaire de Dijon, and Centre de Lutte Contre le Cancer Georges François Leclerc, Dijon, France (LF); INSERM U735, Centre René Huguenin, Saint-Cloud, France (RL); Epidémiologie Clinique, Oncogénétique, Centre René Huguenin, Saint-Cloud, France (CN); Département d’Oncogénétique, Centre Jean Perrin, Clermont-Ferrand, France (Y-JB); Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France (FP); Service de Génétique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France (M-ACR); Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France (LV-B); Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France (SFF); Women's Cancers Program, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (AMi); Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT (SSB); Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia (JLH); Cancer Prevention Institute of California (formerly the Northern California Cancer Center), Fremont and Stanford University School of Medicine, Stanford, CA (EMJ); Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, NY (MBT); Department of Dermatology, University of Utah, Utah (DGo); Department of Clinical Biochemistry (TvOH, LJ) and Department of Oncology (BE), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Pathology, University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland (BAA); Clinical Genetics Service, Department of Medicine, Memorial Sloan- Kettering Cancer Center, New York, NY (KO, TK, JV, AVCD-C, JAP); Istituto Oncologico Veneto—IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy (MM, CC); N.N. Petrov Institute of Oncology, St-Petersburg, Russia (ENI); Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Vilnius, Lithuania (RJ); Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain (IB, CL); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (KBM); Women's Cancer Research Institute at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA (BYK, JG); University of California, San Francisco (UCSF) Cancer Risk Program and Department of Medicine, Department of Epidemiology, and Department of Biostatistics, UCSF, San Francisco, CA (MSB); Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany (RS, BW); Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany (AM); Department of Gynaecology and Obstetrics, Ludwig- Maximillians University Munich, Germany (IR); Institute of Human Genetics, University of Regensburg, Regensburg, Germany (BF); Institute of Human Genetics, Department of Human Genetics, Laboratory of Molecular Genetics, University of Heidelberg, Heidelberg, Germany (CS); Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany (NA); Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany (HD); Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany (RV-M); Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany (KK); Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany (DN); Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany (DG); Molecular Oncology Laboratory, Hospital San Carlos, Madrid, Spain (TC, MdlH); Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland (HN); Helsinki University Central Hospital, Department of Clinical Genetics, Helsinki, Finland (KA); Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada (JS, PS); Cancer Research United Kingdom Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom (DFE)

Affiliation of authors: Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London, UK (SJR, SAG); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (CK, LM, SP, MC, CO, DF, ACA); Cancer Research United Kingdom Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (PDPP); Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (OMS); Queensland Institute of Medical Research, Brisbane, Queensland, Australia (JBee, XC, SHe, ABS, HH, GC-T); Department of Laboratory Medicine and Pathology (FJC, XW) and Department of Health Sciences Research (ZF), Mayo Clinic, Rochester, MN; Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy (PP, PR); Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy (SMa, BP, DZ, GR); Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy (MB); Division of Experimental Oncology 1, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy (AV); Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy (AA); Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy (LO); Medical Genetics Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy (LP); Department of Epidemiology and Prevention, IRCCS Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy (VG); Cogentech, Consortium for Genomics Technology, Milan, Italy (FC); Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (MHG, PLM); Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (ILA); Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada (GG); Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (HO); Clinical Genetics, Odense University Hospital, Odense, Denmark (MT, TAK, A-MG); Clinical Genetics, Rigshospital Copenhagen, Denmark (A-MG); Clinical Genetics, Vejle Hospital, Vejle, Denmark (DC); Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark (UBJ); Section of Genetic Oncology, Department of Oncology, University Hospital of Pisa, Pisa, Italy (MAC); Department of Oncology (HO, AB) and Department of Clinical Genetics (UK), Lund University, Lund, Sweden; Department of Clinical Genetics (AL) and Department of Oncology (BA), Karolinska University Hospital, Stockholm, Sweden; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden (PK); Department of Oncology, Linköping University Hospital, Linköping, Sweden (MSA); Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA (SLN, YCD), Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA (KLN, SMD); International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland ( AJ, JL, TH, TB, JGron, BG, CCy, TD); Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (AO); Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain (MD); Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain (M-IT); Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (JB); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (UH); Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (MAR); Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands (SV); Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands (MAT-L); Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands (MPV, CJA); DNA Diagnostics, Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (DB); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (MGEMA); Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands (TAvO); Department of Clinical Genetics, University Hospital Maastricht, Maastricht, the Netherlands (MJB); Department of Clinical Genetics, VU Medical Center, Amsterdam, the Netherlands (HEJM-H); Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK (AMD); Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK (DGE); Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK (RE); Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK (GP); West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK (TCo); Clinical Genetics Department, St George's Hospital, University of London, London, UK (SH); Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK (CB); Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, UK (PJM ); South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK (MP); Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire (MJK); All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK (MTR); North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK (LES);Clinical Genetics Department, St Michael's Hospital, Bristol, UK (AD); North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Aberdeen, UK (HG); Women's Cancer Program, Departrment of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA ( AKG, MBD); INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France (DS-L, VM, LC); Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (SM, LB); CNRS UMR5558, Université Lyon 1, and Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France (VB); Department of Genetics, Centre Hospitalier Universitaire de Grenoble, and Institut Albert Bonniot, Université de Grenoble, Grenoble, France (DL); Centre de Génétique, Centre Hospitalier Universitaire de Dijon, and Centre de Lutte Contre le Cancer Georges François Leclerc, Dijon, France (LF); INSERM U735, Centre René Huguenin, Saint-Cloud, France (RL); Epidémiologie Clinique, Oncogénétique, Centre René Huguenin, Saint-Cloud, France (CN); Département d’Oncogénétique, Centre Jean Perrin, Clermont-Ferrand, France (Y-JB); Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France (FP); Service de Génétique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France (M-ACR); Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France (LV-B); Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France (SFF); Women's Cancers Program, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (AMi); Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT (SSB); Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia (JLH); Cancer Prevention Institute of California (formerly the Northern California Cancer Center), Fremont and Stanford University School of Medicine, Stanford, CA (EMJ); Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, NY (MBT); Department of Dermatology, University of Utah, Utah (DGo); Department of Clinical Biochemistry (TvOH, LJ) and Department of Oncology (BE), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Pathology, University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland (BAA); Clinical Genetics Service, Department of Medicine, Memorial Sloan- Kettering Cancer Center, New York, NY (KO, TK, JV, AVCD-C, JAP); Istituto Oncologico Veneto—IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy (MM, CC); N.N. Petrov Institute of Oncology, St-Petersburg, Russia (ENI); Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Vilnius, Lithuania (RJ); Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain (IB, CL); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (KBM); Women's Cancer Research Institute at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA (BYK, JG); University of California, San Francisco (UCSF) Cancer Risk Program and Department of Medicine, Department of Epidemiology, and Department of Biostatistics, UCSF, San Francisco, CA (MSB); Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany (RS, BW); Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany (AM); Department of Gynaecology and Obstetrics, Ludwig- Maximillians University Munich, Germany (IR); Institute of Human Genetics, University of Regensburg, Regensburg, Germany (BF); Institute of Human Genetics, Department of Human Genetics, Laboratory of Molecular Genetics, University of Heidelberg, Heidelberg, Germany (CS); Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany (NA); Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany (HD); Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany (RV-M); Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany (KK); Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany (DN); Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany (DG); Molecular Oncology Laboratory, Hospital San Carlos, Madrid, Spain (TC, MdlH); Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland (HN); Helsinki University Central Hospital, Department of Clinical Genetics, Helsinki, Finland (KA); Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada (JS, PS); Cancer Research United Kingdom Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom (DFE)

Affiliation of authors: Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London, UK (SJR, SAG); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (CK, LM, SP, MC, CO, DF, ACA); Cancer Research United Kingdom Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (PDPP); Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (OMS); Queensland Institute of Medical Research, Brisbane, Queensland, Australia (JBee, XC, SHe, ABS, HH, GC-T); Department of Laboratory Medicine and Pathology (FJC, XW) and Department of Health Sciences Research (ZF), Mayo Clinic, Rochester, MN; Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy (PP, PR); Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy (SMa, BP, DZ, GR); Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy (MB); Division of Experimental Oncology 1, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy (AV); Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy (AA); Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy (LO); Medical Genetics Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy (LP); Department of Epidemiology and Prevention, IRCCS Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy (VG); Cogentech, Consortium for Genomics Technology, Milan, Italy (FC); Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (MHG, PLM); Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (ILA); Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada (GG); Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (HO); Clinical Genetics, Odense University Hospital, Odense, Denmark (MT, TAK, A-MG); Clinical Genetics, Rigshospital Copenhagen, Denmark (A-MG); Clinical Genetics, Vejle Hospital, Vejle, Denmark (DC); Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark (UBJ); Section of Genetic Oncology, Department of Oncology, University Hospital of Pisa, Pisa, Italy (MAC); Department of Oncology (HO, AB) and Department of Clinical Genetics (UK), Lund University, Lund, Sweden; Department of Clinical Genetics (AL) and Department of Oncology (BA), Karolinska University Hospital, Stockholm, Sweden; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden (PK); Department of Oncology, Linköping University Hospital, Linköping, Sweden (MSA); Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA (SLN, YCD), Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA (KLN, SMD); International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland ( AJ, JL, TH, TB, JGron, BG, CCy, TD); Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (AO); Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain (MD); Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain (M-IT); Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (JB); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (UH); Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (MAR); Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands (SV); Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands (MAT-L); Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands (MPV, CJA); DNA Diagnostics, Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (DB); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (MGEMA); Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands (TAvO); Department of Clinical Genetics, University Hospital Maastricht, Maastricht, the Netherlands (MJB); Department of Clinical Genetics, VU Medical Center, Amsterdam, the Netherlands (HEJM-H); Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK (AMD); Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK (DGE); Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK (RE); Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK (GP); West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK (TCo); Clinical Genetics Department, St George's Hospital, University of London, London, UK (SH); Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK (CB); Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, UK (PJM ); South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK (MP); Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire (MJK); All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK (MTR); North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK (LES);Clinical Genetics Department, St Michael's Hospital, Bristol, UK (AD); North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Aberdeen, UK (HG); Women's Cancer Program, Departrment of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA ( AKG, MBD); INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France (DS-L, VM, LC); Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (SM, LB); CNRS UMR5558, Université Lyon 1, and Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France (VB); Department of Genetics, Centre Hospitalier Universitaire de Grenoble, and Institut Albert Bonniot, Université de Grenoble, Grenoble, France (DL); Centre de Génétique, Centre Hospitalier Universitaire de Dijon, and Centre de Lutte Contre le Cancer Georges François Leclerc, Dijon, France (LF); INSERM U735, Centre René Huguenin, Saint-Cloud, France (RL); Epidémiologie Clinique, Oncogénétique, Centre René Huguenin, Saint-Cloud, France (CN); Département d’Oncogénétique, Centre Jean Perrin, Clermont-Ferrand, France (Y-JB); Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France (FP); Service de Génétique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France (M-ACR); Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France (LV-B); Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France (SFF); Women's Cancers Program, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (AMi); Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT (SSB); Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia (JLH); Cancer Prevention Institute of California (formerly the Northern California Cancer Center), Fremont and Stanford University School of Medicine, Stanford, CA (EMJ); Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, NY (MBT); Department of Dermatology, University of Utah, Utah (DGo); Department of Clinical Biochemistry (TvOH, LJ) and Department of Oncology (BE), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Pathology, University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland (BAA); Clinical Genetics Service, Department of Medicine, Memorial Sloan- Kettering Cancer Center, New York, NY (KO, TK, JV, AVCD-C, JAP); Istituto Oncologico Veneto—IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy (MM, CC); N.N. Petrov Institute of Oncology, St-Petersburg, Russia (ENI); Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Vilnius, Lithuania (RJ); Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain (IB, CL); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (KBM); Women's Cancer Research Institute at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA (BYK, JG); University of California, San Francisco (UCSF) Cancer Risk Program and Department of Medicine, Department of Epidemiology, and Department of Biostatistics, UCSF, San Francisco, CA (MSB); Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany (RS, BW); Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany (AM); Department of Gynaecology and Obstetrics, Ludwig- Maximillians University Munich, Germany (IR); Institute of Human Genetics, University of Regensburg, Regensburg, Germany (BF); Institute of Human Genetics, Department of Human Genetics, Laboratory of Molecular Genetics, University of Heidelberg, Heidelberg, Germany (CS); Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany (NA); Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany (HD); Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany (RV-M); Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany (KK); Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany (DN); Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany (DG); Molecular Oncology Laboratory, Hospital San Carlos, Madrid, Spain (TC, MdlH); Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland (HN); Helsinki University Central Hospital, Department of Clinical Genetics, Helsinki, Finland (KA); Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada (JS, PS); Cancer Research United Kingdom Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom (DFE)

Affiliation of authors: Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London, UK (SJR, SAG); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (CK, LM, SP, MC, CO, DF, ACA); Cancer Research United Kingdom Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (PDPP); Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (OMS); Queensland Institute of Medical Research, Brisbane, Queensland, Australia (JBee, XC, SHe, ABS, HH, GC-T); Department of Laboratory Medicine and Pathology (FJC, XW) and Department of Health Sciences Research (ZF), Mayo Clinic, Rochester, MN; Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy (PP, PR); Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy (SMa, BP, DZ, GR); Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy (MB); Division of Experimental Oncology 1, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy (AV); Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy (AA); Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy (LO); Medical Genetics Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy (LP); Department of Epidemiology and Prevention, IRCCS Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy (VG); Cogentech, Consortium for Genomics Technology, Milan, Italy (FC); Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (MHG, PLM); Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (ILA); Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada (GG); Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (HO); Clinical Genetics, Odense University Hospital, Odense, Denmark (MT, TAK, A-MG); Clinical Genetics, Rigshospital Copenhagen, Denmark (A-MG); Clinical Genetics, Vejle Hospital, Vejle, Denmark (DC); Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark (UBJ); Section of Genetic Oncology, Department of Oncology, University Hospital of Pisa, Pisa, Italy (MAC); Department of Oncology (HO, AB) and Department of Clinical Genetics (UK), Lund University, Lund, Sweden; Department of Clinical Genetics (AL) and Department of Oncology (BA), Karolinska University Hospital, Stockholm, Sweden; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden (PK); Department of Oncology, Linköping University Hospital, Linköping, Sweden (MSA); Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA (SLN, YCD), Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA (KLN, SMD); International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland ( AJ, JL, TH, TB, JGron, BG, CCy, TD); Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (AO); Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain (MD); Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain (M-IT); Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (JB); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (UH); Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (MAR); Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands (SV); Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands (MAT-L); Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands (MPV, CJA); DNA Diagnostics, Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (DB); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (MGEMA); Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands (TAvO); Department of Clinical Genetics, University Hospital Maastricht, Maastricht, the Netherlands (MJB); Department of Clinical Genetics, VU Medical Center, Amsterdam, the Netherlands (HEJM-H); Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK (AMD); Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK (DGE); Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK (RE); Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK (GP); West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK (TCo); Clinical Genetics Department, St George's Hospital, University of London, London, UK (SH); Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK (CB); Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, UK (PJM ); South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK (MP); Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire (MJK); All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK (MTR); North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK (LES);Clinical Genetics Department, St Michael's Hospital, Bristol, UK (AD); North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Aberdeen, UK (HG); Women's Cancer Program, Departrment of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA ( AKG, MBD); INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France (DS-L, VM, LC); Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (SM, LB); CNRS UMR5558, Université Lyon 1, and Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France (VB); Department of Genetics, Centre Hospitalier Universitaire de Grenoble, and Institut Albert Bonniot, Université de Grenoble, Grenoble, France (DL); Centre de Génétique, Centre Hospitalier Universitaire de Dijon, and Centre de Lutte Contre le Cancer Georges François Leclerc, Dijon, France (LF); INSERM U735, Centre René Huguenin, Saint-Cloud, France (RL); Epidémiologie Clinique, Oncogénétique, Centre René Huguenin, Saint-Cloud, France (CN); Département d’Oncogénétique, Centre Jean Perrin, Clermont-Ferrand, France (Y-JB); Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France (FP); Service de Génétique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France (M-ACR); Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France (LV-B); Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France (SFF); Women's Cancers Program, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (AMi); Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT (SSB); Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia (JLH); Cancer Prevention Institute of California (formerly the Northern California Cancer Center), Fremont and Stanford University School of Medicine, Stanford, CA (EMJ); Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, NY (MBT); Department of Dermatology, University of Utah, Utah (DGo); Department of Clinical Biochemistry (TvOH, LJ) and Department of Oncology (BE), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Pathology, University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland (BAA); Clinical Genetics Service, Department of Medicine, Memorial Sloan- Kettering Cancer Center, New York, NY (KO, TK, JV, AVCD-C, JAP); Istituto Oncologico Veneto—IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy (MM, CC); N.N. Petrov Institute of Oncology, St-Petersburg, Russia (ENI); Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Vilnius, Lithuania (RJ); Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain (IB, CL); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (KBM); Women's Cancer Research Institute at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA (BYK, JG); University of California, San Francisco (UCSF) Cancer Risk Program and Department of Medicine, Department of Epidemiology, and Department of Biostatistics, UCSF, San Francisco, CA (MSB); Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany (RS, BW); Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany (AM); Department of Gynaecology and Obstetrics, Ludwig- Maximillians University Munich, Germany (IR); Institute of Human Genetics, University of Regensburg, Regensburg, Germany (BF); Institute of Human Genetics, Department of Human Genetics, Laboratory of Molecular Genetics, University of Heidelberg, Heidelberg, Germany (CS); Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany (NA); Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany (HD); Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany (RV-M); Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany (KK); Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany (DN); Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany (DG); Molecular Oncology Laboratory, Hospital San Carlos, Madrid, Spain (TC, MdlH); Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland (HN); Helsinki University Central Hospital, Department of Clinical Genetics, Helsinki, Finland (KA); Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada (JS, PS); Cancer Research United Kingdom Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom (DFE)

Affiliation of authors: Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London, UK (SJR, SAG); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (CK, LM, SP, MC, CO, DF, ACA); Cancer Research United Kingdom Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (PDPP); Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (OMS); Queensland Institute of Medical Research, Brisbane, Queensland, Australia (JBee, XC, SHe, ABS, HH, GC-T); Department of Laboratory Medicine and Pathology (FJC, XW) and Department of Health Sciences Research (ZF), Mayo Clinic, Rochester, MN; Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy (PP, PR); Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy (SMa, BP, DZ, GR); Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy (MB); Division of Experimental Oncology 1, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy (AV); Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy (AA); Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy (LO); Medical Genetics Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy (LP); Department of Epidemiology and Prevention, IRCCS Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy (VG); Cogentech, Consortium for Genomics Technology, Milan, Italy (FC); Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (MHG, PLM); Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (ILA); Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada (GG); Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (HO); Clinical Genetics, Odense University Hospital, Odense, Denmark (MT, TAK, A-MG); Clinical Genetics, Rigshospital Copenhagen, Denmark (A-MG); Clinical Genetics, Vejle Hospital, Vejle, Denmark (DC); Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark (UBJ); Section of Genetic Oncology, Department of Oncology, University Hospital of Pisa, Pisa, Italy (MAC); Department of Oncology (HO, AB) and Department of Clinical Genetics (UK), Lund University, Lund, Sweden; Department of Clinical Genetics (AL) and Department of Oncology (BA), Karolinska University Hospital, Stockholm, Sweden; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden (PK); Department of Oncology, Linköping University Hospital, Linköping, Sweden (MSA); Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA (SLN, YCD), Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA (KLN, SMD); International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland ( AJ, JL, TH, TB, JGron, BG, CCy, TD); Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (AO); Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain (MD); Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain (M-IT); Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (JB); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (UH); Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (MAR); Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands (SV); Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands (MAT-L); Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands (MPV, CJA); DNA Diagnostics, Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (DB); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (MGEMA); Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands (TAvO); Department of Clinical Genetics, University Hospital Maastricht, Maastricht, the Netherlands (MJB); Department of Clinical Genetics, VU Medical Center, Amsterdam, the Netherlands (HEJM-H); Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK (AMD); Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK (DGE); Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK (RE); Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK (GP); West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK (TCo); Clinical Genetics Department, St George's Hospital, University of London, London, UK (SH); Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK (CB); Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, UK (PJM ); South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK (MP); Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire (MJK); All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK (MTR); North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK (LES);Clinical Genetics Department, St Michael's Hospital, Bristol, UK (AD); North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Aberdeen, UK (HG); Women's Cancer Program, Departrment of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA ( AKG, MBD); INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France (DS-L, VM, LC); Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (SM, LB); CNRS UMR5558, Université Lyon 1, and Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France (VB); Department of Genetics, Centre Hospitalier Universitaire de Grenoble, and Institut Albert Bonniot, Université de Grenoble, Grenoble, France (DL); Centre de Génétique, Centre Hospitalier Universitaire de Dijon, and Centre de Lutte Contre le Cancer Georges François Leclerc, Dijon, France (LF); INSERM U735, Centre René Huguenin, Saint-Cloud, France (RL); Epidémiologie Clinique, Oncogénétique, Centre René Huguenin, Saint-Cloud, France (CN); Département d’Oncogénétique, Centre Jean Perrin, Clermont-Ferrand, France (Y-JB); Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France (FP); Service de Génétique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France (M-ACR); Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France (LV-B); Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France (SFF); Women's Cancers Program, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (AMi); Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT (SSB); Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia (JLH); Cancer Prevention Institute of California (formerly the Northern California Cancer Center), Fremont and Stanford University School of Medicine, Stanford, CA (EMJ); Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, NY (MBT); Department of Dermatology, University of Utah, Utah (DGo); Department of Clinical Biochemistry (TvOH, LJ) and Department of Oncology (BE), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Pathology, University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland (BAA); Clinical Genetics Service, Department of Medicine, Memorial Sloan- Kettering Cancer Center, New York, NY (KO, TK, JV, AVCD-C, JAP); Istituto Oncologico Veneto—IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy (MM, CC); N.N. Petrov Institute of Oncology, St-Petersburg, Russia (ENI); Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Vilnius, Lithuania (RJ); Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain (IB, CL); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (KBM); Women's Cancer Research Institute at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA (BYK, JG); University of California, San Francisco (UCSF) Cancer Risk Program and Department of Medicine, Department of Epidemiology, and Department of Biostatistics, UCSF, San Francisco, CA (MSB); Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany (RS, BW); Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany (AM); Department of Gynaecology and Obstetrics, Ludwig- Maximillians University Munich, Germany (IR); Institute of Human Genetics, University of Regensburg, Regensburg, Germany (BF); Institute of Human Genetics, Department of Human Genetics, Laboratory of Molecular Genetics, University of Heidelberg, Heidelberg, Germany (CS); Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany (NA); Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany (HD); Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany (RV-M); Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany (KK); Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany (DN); Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany (DG); Molecular Oncology Laboratory, Hospital San Carlos, Madrid, Spain (TC, MdlH); Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland (HN); Helsinki University Central Hospital, Department of Clinical Genetics, Helsinki, Finland (KA); Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada (JS, PS); Cancer Research United Kingdom Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom (DFE)

Affiliation of authors: Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London, UK (SJR, SAG); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (CK, LM, SP, MC, CO, DF, ACA); Cancer Research United Kingdom Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (PDPP); Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (OMS); Queensland Institute of Medical Research, Brisbane, Queensland, Australia (JBee, XC, SHe, ABS, HH, GC-T); Department of Laboratory Medicine and Pathology (FJC, XW) and Department of Health Sciences Research (ZF), Mayo Clinic, Rochester, MN; Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy (PP, PR); Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy (SMa, BP, DZ, GR); Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy (MB); Division of Experimental Oncology 1, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy (AV); Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy (AA); Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy (LO); Medical Genetics Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy (LP); Department of Epidemiology and Prevention, IRCCS Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy (VG); Cogentech, Consortium for Genomics Technology, Milan, Italy (FC); Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (MHG, PLM); Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (ILA); Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada (GG); Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (HO); Clinical Genetics, Odense University Hospital, Odense, Denmark (MT, TAK, A-MG); Clinical Genetics, Rigshospital Copenhagen, Denmark (A-MG); Clinical Genetics, Vejle Hospital, Vejle, Denmark (DC); Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark (UBJ); Section of Genetic Oncology, Department of Oncology, University Hospital of Pisa, Pisa, Italy (MAC); Department of Oncology (HO, AB) and Department of Clinical Genetics (UK), Lund University, Lund, Sweden; Department of Clinical Genetics (AL) and Department of Oncology (BA), Karolinska University Hospital, Stockholm, Sweden; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden (PK); Department of Oncology, Linköping University Hospital, Linköping, Sweden (MSA); Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA (SLN, YCD), Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA (KLN, SMD); International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland ( AJ, JL, TH, TB, JGron, BG, CCy, TD); Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (AO); Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain (MD); Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain (M-IT); Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (JB); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (UH); Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (MAR); Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands (SV); Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands (MAT-L); Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands (MPV, CJA); DNA Diagnostics, Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (DB); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (MGEMA); Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands (TAvO); Department of Clinical Genetics, University Hospital Maastricht, Maastricht, the Netherlands (MJB); Department of Clinical Genetics, VU Medical Center, Amsterdam, the Netherlands (HEJM-H); Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK (AMD); Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK (DGE); Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK (RE); Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK (GP); West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK (TCo); Clinical Genetics Department, St George's Hospital, University of London, London, UK (SH); Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK (CB); Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, UK (PJM ); South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK (MP); Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire (MJK); All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK (MTR); North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK (LES);Clinical Genetics Department, St Michael's Hospital, Bristol, UK (AD); North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Aberdeen, UK (HG); Women's Cancer Program, Departrment of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA ( AKG, MBD); INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France (DS-L, VM, LC); Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (SM, LB); CNRS UMR5558, Université Lyon 1, and Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France (VB); Department of Genetics, Centre Hospitalier Universitaire de Grenoble, and Institut Albert Bonniot, Université de Grenoble, Grenoble, France (DL); Centre de Génétique, Centre Hospitalier Universitaire de Dijon, and Centre de Lutte Contre le Cancer Georges François Leclerc, Dijon, France (LF); INSERM U735, Centre René Huguenin, Saint-Cloud, France (RL); Epidémiologie Clinique, Oncogénétique, Centre René Huguenin, Saint-Cloud, France (CN); Département d’Oncogénétique, Centre Jean Perrin, Clermont-Ferrand, France (Y-JB); Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France (FP); Service de Génétique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France (M-ACR); Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France (LV-B); Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France (SFF); Women's Cancers Program, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (AMi); Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT (SSB); Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia (JLH); Cancer Prevention Institute of California (formerly the Northern California Cancer Center), Fremont and Stanford University School of Medicine, Stanford, CA (EMJ); Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, NY (MBT); Department of Dermatology, University of Utah, Utah (DGo); Department of Clinical Biochemistry (TvOH, LJ) and Department of Oncology (BE), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Pathology, University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland (BAA); Clinical Genetics Service, Department of Medicine, Memorial Sloan- Kettering Cancer Center, New York, NY (KO, TK, JV, AVCD-C, JAP); Istituto Oncologico Veneto—IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy (MM, CC); N.N. Petrov Institute of Oncology, St-Petersburg, Russia (ENI); Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Vilnius, Lithuania (RJ); Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain (IB, CL); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (KBM); Women's Cancer Research Institute at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA (BYK, JG); University of California, San Francisco (UCSF) Cancer Risk Program and Department of Medicine, Department of Epidemiology, and Department of Biostatistics, UCSF, San Francisco, CA (MSB); Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany (RS, BW); Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany (AM); Department of Gynaecology and Obstetrics, Ludwig- Maximillians University Munich, Germany (IR); Institute of Human Genetics, University of Regensburg, Regensburg, Germany (BF); Institute of Human Genetics, Department of Human Genetics, Laboratory of Molecular Genetics, University of Heidelberg, Heidelberg, Germany (CS); Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany (NA); Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany (HD); Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany (RV-M); Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany (KK); Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany (DN); Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany (DG); Molecular Oncology Laboratory, Hospital San Carlos, Madrid, Spain (TC, MdlH); Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland (HN); Helsinki University Central Hospital, Department of Clinical Genetics, Helsinki, Finland (KA); Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada (JS, PS); Cancer Research United Kingdom Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom (DFE)

Affiliation of authors: Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London, UK (SJR, SAG); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (CK, LM, SP, MC, CO, DF, ACA); Cancer Research United Kingdom Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (PDPP); Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (OMS); Queensland Institute of Medical Research, Brisbane, Queensland, Australia (JBee, XC, SHe, ABS, HH, GC-T); Department of Laboratory Medicine and Pathology (FJC, XW) and Department of Health Sciences Research (ZF), Mayo Clinic, Rochester, MN; Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy (PP, PR); Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy (SMa, BP, DZ, GR); Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy (MB); Division of Experimental Oncology 1, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy (AV); Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy (AA); Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy (LO); Medical Genetics Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy (LP); Department of Epidemiology and Prevention, IRCCS Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy (VG); Cogentech, Consortium for Genomics Technology, Milan, Italy (FC); Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (MHG, PLM); Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (ILA); Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada (GG); Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (HO); Clinical Genetics, Odense University Hospital, Odense, Denmark (MT, TAK, A-MG); Clinical Genetics, Rigshospital Copenhagen, Denmark (A-MG); Clinical Genetics, Vejle Hospital, Vejle, Denmark (DC); Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark (UBJ); Section of Genetic Oncology, Department of Oncology, University Hospital of Pisa, Pisa, Italy (MAC); Department of Oncology (HO, AB) and Department of Clinical Genetics (UK), Lund University, Lund, Sweden; Department of Clinical Genetics (AL) and Department of Oncology (BA), Karolinska University Hospital, Stockholm, Sweden; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden (PK); Department of Oncology, Linköping University Hospital, Linköping, Sweden (MSA); Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA (SLN, YCD), Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA (KLN, SMD); International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland ( AJ, JL, TH, TB, JGron, BG, CCy, TD); Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (AO); Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain (MD); Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain (M-IT); Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (JB); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (UH); Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (MAR); Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands (SV); Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands (MAT-L); Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands (MPV, CJA); DNA Diagnostics, Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (DB); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (MGEMA); Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands (TAvO); Department of Clinical Genetics, University Hospital Maastricht, Maastricht, the Netherlands (MJB); Department of Clinical Genetics, VU Medical Center, Amsterdam, the Netherlands (HEJM-H); Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK (AMD); Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK (DGE); Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK (RE); Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK (GP); West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK (TCo); Clinical Genetics Department, St George's Hospital, University of London, London, UK (SH); Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK (CB); Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, UK (PJM ); South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK (MP); Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire (MJK); All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK (MTR); North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK (LES);Clinical Genetics Department, St Michael's Hospital, Bristol, UK (AD); North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Aberdeen, UK (HG); Women's Cancer Program, Departrment of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA ( AKG, MBD); INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France (DS-L, VM, LC); Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (SM, LB); CNRS UMR5558, Université Lyon 1, and Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France (VB); Department of Genetics, Centre Hospitalier Universitaire de Grenoble, and Institut Albert Bonniot, Université de Grenoble, Grenoble, France (DL); Centre de Génétique, Centre Hospitalier Universitaire de Dijon, and Centre de Lutte Contre le Cancer Georges François Leclerc, Dijon, France (LF); INSERM U735, Centre René Huguenin, Saint-Cloud, France (RL); Epidémiologie Clinique, Oncogénétique, Centre René Huguenin, Saint-Cloud, France (CN); Département d’Oncogénétique, Centre Jean Perrin, Clermont-Ferrand, France (Y-JB); Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France (FP); Service de Génétique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France (M-ACR); Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France (LV-B); Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France (SFF); Women's Cancers Program, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (AMi); Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT (SSB); Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia (JLH); Cancer Prevention Institute of California (formerly the Northern California Cancer Center), Fremont and Stanford University School of Medicine, Stanford, CA (EMJ); Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, NY (MBT); Department of Dermatology, University of Utah, Utah (DGo); Department of Clinical Biochemistry (TvOH, LJ) and Department of Oncology (BE), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Pathology, University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland (BAA); Clinical Genetics Service, Department of Medicine, Memorial Sloan- Kettering Cancer Center, New York, NY (KO, TK, JV, AVCD-C, JAP); Istituto Oncologico Veneto—IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy (MM, CC); N.N. Petrov Institute of Oncology, St-Petersburg, Russia (ENI); Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Vilnius, Lithuania (RJ); Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain (IB, CL); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (KBM); Women's Cancer Research Institute at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA (BYK, JG); University of California, San Francisco (UCSF) Cancer Risk Program and Department of Medicine, Department of Epidemiology, and Department of Biostatistics, UCSF, San Francisco, CA (MSB); Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany (RS, BW); Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany (AM); Department of Gynaecology and Obstetrics, Ludwig- Maximillians University Munich, Germany (IR); Institute of Human Genetics, University of Regensburg, Regensburg, Germany (BF); Institute of Human Genetics, Department of Human Genetics, Laboratory of Molecular Genetics, University of Heidelberg, Heidelberg, Germany (CS); Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany (NA); Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany (HD); Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany (RV-M); Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany (KK); Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany (DN); Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany (DG); Molecular Oncology Laboratory, Hospital San Carlos, Madrid, Spain (TC, MdlH); Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland (HN); Helsinki University Central Hospital, Department of Clinical Genetics, Helsinki, Finland (KA); Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada (JS, PS); Cancer Research United Kingdom Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom (DFE)

Affiliation of authors: Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London, UK (SJR, SAG); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (CK, LM, SP, MC, CO, DF, ACA); Cancer Research United Kingdom Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (PDPP); Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (OMS); Queensland Institute of Medical Research, Brisbane, Queensland, Australia (JBee, XC, SHe, ABS, HH, GC-T); Department of Laboratory Medicine and Pathology (FJC, XW) and Department of Health Sciences Research (ZF), Mayo Clinic, Rochester, MN; Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy (PP, PR); Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy (SMa, BP, DZ, GR); Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy (MB); Division of Experimental Oncology 1, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy (AV); Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy (AA); Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy (LO); Medical Genetics Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy (LP); Department of Epidemiology and Prevention, IRCCS Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy (VG); Cogentech, Consortium for Genomics Technology, Milan, Italy (FC); Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (MHG, PLM); Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (ILA); Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada (GG); Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (HO); Clinical Genetics, Odense University Hospital, Odense, Denmark (MT, TAK, A-MG); Clinical Genetics, Rigshospital Copenhagen, Denmark (A-MG); Clinical Genetics, Vejle Hospital, Vejle, Denmark (DC); Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark (UBJ); Section of Genetic Oncology, Department of Oncology, University Hospital of Pisa, Pisa, Italy (MAC); Department of Oncology (HO, AB) and Department of Clinical Genetics (UK), Lund University, Lund, Sweden; Department of Clinical Genetics (AL) and Department of Oncology (BA), Karolinska University Hospital, Stockholm, Sweden; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden (PK); Department of Oncology, Linköping University Hospital, Linköping, Sweden (MSA); Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA (SLN, YCD), Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA (KLN, SMD); International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland ( AJ, JL, TH, TB, JGron, BG, CCy, TD); Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (AO); Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain (MD); Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain (M-IT); Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (JB); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (UH); Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (MAR); Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands (SV); Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands (MAT-L); Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands (MPV, CJA); DNA Diagnostics, Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (DB); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (MGEMA); Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands (TAvO); Department of Clinical Genetics, University Hospital Maastricht, Maastricht, the Netherlands (MJB); Department of Clinical Genetics, VU Medical Center, Amsterdam, the Netherlands (HEJM-H); Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK (AMD); Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK (DGE); Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK (RE); Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK (GP); West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK (TCo); Clinical Genetics Department, St George's Hospital, University of London, London, UK (SH); Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK (CB); Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, UK (PJM ); South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK (MP); Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire (MJK); All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK (MTR); North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK (LES);Clinical Genetics Department, St Michael's Hospital, Bristol, UK (AD); North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Aberdeen, UK (HG); Women's Cancer Program, Departrment of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA ( AKG, MBD); INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France (DS-L, VM, LC); Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (SM, LB); CNRS UMR5558, Université Lyon 1, and Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France (VB); Department of Genetics, Centre Hospitalier Universitaire de Grenoble, and Institut Albert Bonniot, Université de Grenoble, Grenoble, France (DL); Centre de Génétique, Centre Hospitalier Universitaire de Dijon, and Centre de Lutte Contre le Cancer Georges François Leclerc, Dijon, France (LF); INSERM U735, Centre René Huguenin, Saint-Cloud, France (RL); Epidémiologie Clinique, Oncogénétique, Centre René Huguenin, Saint-Cloud, France (CN); Département d’Oncogénétique, Centre Jean Perrin, Clermont-Ferrand, France (Y-JB); Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France (FP); Service de Génétique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France (M-ACR); Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France (LV-B); Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France (SFF); Women's Cancers Program, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (AMi); Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT (SSB); Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia (JLH); Cancer Prevention Institute of California (formerly the Northern California Cancer Center), Fremont and Stanford University School of Medicine, Stanford, CA (EMJ); Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, NY (MBT); Department of Dermatology, University of Utah, Utah (DGo); Department of Clinical Biochemistry (TvOH, LJ) and Department of Oncology (BE), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Pathology, University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland (BAA); Clinical Genetics Service, Department of Medicine, Memorial Sloan- Kettering Cancer Center, New York, NY (KO, TK, JV, AVCD-C, JAP); Istituto Oncologico Veneto—IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy (MM, CC); N.N. Petrov Institute of Oncology, St-Petersburg, Russia (ENI); Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Vilnius, Lithuania (RJ); Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain (IB, CL); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (KBM); Women's Cancer Research Institute at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA (BYK, JG); University of California, San Francisco (UCSF) Cancer Risk Program and Department of Medicine, Department of Epidemiology, and Department of Biostatistics, UCSF, San Francisco, CA (MSB); Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany (RS, BW); Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany (AM); Department of Gynaecology and Obstetrics, Ludwig- Maximillians University Munich, Germany (IR); Institute of Human Genetics, University of Regensburg, Regensburg, Germany (BF); Institute of Human Genetics, Department of Human Genetics, Laboratory of Molecular Genetics, University of Heidelberg, Heidelberg, Germany (CS); Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany (NA); Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany (HD); Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany (RV-M); Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany (KK); Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany (DN); Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany (DG); Molecular Oncology Laboratory, Hospital San Carlos, Madrid, Spain (TC, MdlH); Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland (HN); Helsinki University Central Hospital, Department of Clinical Genetics, Helsinki, Finland (KA); Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada (JS, PS); Cancer Research United Kingdom Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom (DFE)

Affiliation of authors: Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London, UK (SJR, SAG); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (CK, LM, SP, MC, CO, DF, ACA); Cancer Research United Kingdom Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (PDPP); Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (OMS); Queensland Institute of Medical Research, Brisbane, Queensland, Australia (JBee, XC, SHe, ABS, HH, GC-T); Department of Laboratory Medicine and Pathology (FJC, XW) and Department of Health Sciences Research (ZF), Mayo Clinic, Rochester, MN; Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy (PP, PR); Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy (SMa, BP, DZ, GR); Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy (MB); Division of Experimental Oncology 1, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy (AV); Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy (AA); Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy (LO); Medical Genetics Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy (LP); Department of Epidemiology and Prevention, IRCCS Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy (VG); Cogentech, Consortium for Genomics Technology, Milan, Italy (FC); Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (MHG, PLM); Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (ILA); Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada (GG); Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (HO); Clinical Genetics, Odense University Hospital, Odense, Denmark (MT, TAK, A-MG); Clinical Genetics, Rigshospital Copenhagen, Denmark (A-MG); Clinical Genetics, Vejle Hospital, Vejle, Denmark (DC); Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark (UBJ); Section of Genetic Oncology, Department of Oncology, University Hospital of Pisa, Pisa, Italy (MAC); Department of Oncology (HO, AB) and Department of Clinical Genetics (UK), Lund University, Lund, Sweden; Department of Clinical Genetics (AL) and Department of Oncology (BA), Karolinska University Hospital, Stockholm, Sweden; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden (PK); Department of Oncology, Linköping University Hospital, Linköping, Sweden (MSA); Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA (SLN, YCD), Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA (KLN, SMD); International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland ( AJ, JL, TH, TB, JGron, BG, CCy, TD); Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (AO); Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain (MD); Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain (M-IT); Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (JB); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (UH); Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (MAR); Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands (SV); Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands (MAT-L); Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands (MPV, CJA); DNA Diagnostics, Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (DB); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (MGEMA); Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands (TAvO); Department of Clinical Genetics, University Hospital Maastricht, Maastricht, the Netherlands (MJB); Department of Clinical Genetics, VU Medical Center, Amsterdam, the Netherlands (HEJM-H); Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK (AMD); Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK (DGE); Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK (RE); Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK (GP); West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK (TCo); Clinical Genetics Department, St George's Hospital, University of London, London, UK (SH); Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK (CB); Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, UK (PJM ); South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK (MP); Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire (MJK); All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK (MTR); North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK (LES);Clinical Genetics Department, St Michael's Hospital, Bristol, UK (AD); North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Aberdeen, UK (HG); Women's Cancer Program, Departrment of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA ( AKG, MBD); INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France (DS-L, VM, LC); Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (SM, LB); CNRS UMR5558, Université Lyon 1, and Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France (VB); Department of Genetics, Centre Hospitalier Universitaire de Grenoble, and Institut Albert Bonniot, Université de Grenoble, Grenoble, France (DL); Centre de Génétique, Centre Hospitalier Universitaire de Dijon, and Centre de Lutte Contre le Cancer Georges François Leclerc, Dijon, France (LF); INSERM U735, Centre René Huguenin, Saint-Cloud, France (RL); Epidémiologie Clinique, Oncogénétique, Centre René Huguenin, Saint-Cloud, France (CN); Département d’Oncogénétique, Centre Jean Perrin, Clermont-Ferrand, France (Y-JB); Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France (FP); Service de Génétique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France (M-ACR); Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France (LV-B); Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France (SFF); Women's Cancers Program, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (AMi); Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT (SSB); Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia (JLH); Cancer Prevention Institute of California (formerly the Northern California Cancer Center), Fremont and Stanford University School of Medicine, Stanford, CA (EMJ); Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, NY (MBT); Department of Dermatology, University of Utah, Utah (DGo); Department of Clinical Biochemistry (TvOH, LJ) and Department of Oncology (BE), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Pathology, University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland (BAA); Clinical Genetics Service, Department of Medicine, Memorial Sloan- Kettering Cancer Center, New York, NY (KO, TK, JV, AVCD-C, JAP); Istituto Oncologico Veneto—IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy (MM, CC); N.N. Petrov Institute of Oncology, St-Petersburg, Russia (ENI); Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Vilnius, Lithuania (RJ); Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain (IB, CL); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (KBM); Women's Cancer Research Institute at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA (BYK, JG); University of California, San Francisco (UCSF) Cancer Risk Program and Department of Medicine, Department of Epidemiology, and Department of Biostatistics, UCSF, San Francisco, CA (MSB); Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany (RS, BW); Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany (AM); Department of Gynaecology and Obstetrics, Ludwig- Maximillians University Munich, Germany (IR); Institute of Human Genetics, University of Regensburg, Regensburg, Germany (BF); Institute of Human Genetics, Department of Human Genetics, Laboratory of Molecular Genetics, University of Heidelberg, Heidelberg, Germany (CS); Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany (NA); Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany (HD); Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany (RV-M); Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany (KK); Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany (DN); Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany (DG); Molecular Oncology Laboratory, Hospital San Carlos, Madrid, Spain (TC, MdlH); Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland (HN); Helsinki University Central Hospital, Department of Clinical Genetics, Helsinki, Finland (KA); Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada (JS, PS); Cancer Research United Kingdom Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom (DFE)

Affiliation of authors: Department of Gynaecological Oncology, UCL EGA Institute for Women's Health, University College London, London, UK (SJR, SAG); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (CK, LM, SP, MC, CO, DF, ACA); Cancer Research United Kingdom Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (PDPP); Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, and Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (OMS); Queensland Institute of Medical Research, Brisbane, Queensland, Australia (JBee, XC, SHe, ABS, HH, GC-T); Department of Laboratory Medicine and Pathology (FJC, XW) and Department of Health Sciences Research (ZF), Mayo Clinic, Rochester, MN; Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy (PP, PR); Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy (SMa, BP, DZ, GR); Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy (MB); Division of Experimental Oncology 1, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy (AV); Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy (AA); Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy (LO); Medical Genetics Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy (LP); Department of Epidemiology and Prevention, IRCCS Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy (VG); Cogentech, Consortium for Genomics Technology, Milan, Italy (FC); Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (MHG, PLM); Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (ILA); Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada (GG); Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (HO); Clinical Genetics, Odense University Hospital, Odense, Denmark (MT, TAK, A-MG); Clinical Genetics, Rigshospital Copenhagen, Denmark (A-MG); Clinical Genetics, Vejle Hospital, Vejle, Denmark (DC); Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark (UBJ); Section of Genetic Oncology, Department of Oncology, University Hospital of Pisa, Pisa, Italy (MAC); Department of Oncology (HO, AB) and Department of Clinical Genetics (UK), Lund University, Lund, Sweden; Department of Clinical Genetics (AL) and Department of Oncology (BA), Karolinska University Hospital, Stockholm, Sweden; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden (PK); Department of Oncology, Linköping University Hospital, Linköping, Sweden (MSA); Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, CA (SLN, YCD), Department of Medicine and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA (KLN, SMD); International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland ( AJ, JL, TH, TB, JGron, BG, CCy, TD); Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (AO); Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain (MD); Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain (M-IT); Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain (JB); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (UH); Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands (MAR); Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands (SV); Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, the Netherlands (MAT-L); Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands (MPV, CJA); DNA Diagnostics, Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (DB); Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands (MGEMA); Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands (TAvO); Department of Clinical Genetics, University Hospital Maastricht, Maastricht, the Netherlands (MJB); Department of Clinical Genetics, VU Medical Center, Amsterdam, the Netherlands (HEJM-H); Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK (AMD); Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK (DGE); Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK (RE); Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK (GP); West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK (TCo); Clinical Genetics Department, St George's Hospital, University of London, London, UK (SH); Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK (CB); Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, UK (PJM ); South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK (MP); Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire (MJK); All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK (MTR); North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK (LES);Clinical Genetics Department, St Michael's Hospital, Bristol, UK (AD); North of Scotland Regional Genetics Service, NHS Grampian and University of Aberdeen, Aberdeen, UK (HG); Women's Cancer Program, Departrment of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA ( AKG, MBD); INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France (DS-L, VM, LC); Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France (SM, LB); CNRS UMR5558, Université Lyon 1, and Unité de Prévention et d’Epidémiologie Génétique, Centre Léon Bérard, Lyon, France (VB); Department of Genetics, Centre Hospitalier Universitaire de Grenoble, and Institut Albert Bonniot, Université de Grenoble, Grenoble, France (DL); Centre de Génétique, Centre Hospitalier Universitaire de Dijon, and Centre de Lutte Contre le Cancer Georges François Leclerc, Dijon, France (LF); INSERM U735, Centre René Huguenin, Saint-Cloud, France (RL); Epidémiologie Clinique, Oncogénétique, Centre René Huguenin, Saint-Cloud, France (CN); Département d’Oncogénétique, Centre Jean Perrin, Clermont-Ferrand, France (Y-JB); Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France (FP); Service de Génétique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France (M-ACR); Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France (LV-B); Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France (SFF); Women's Cancers Program, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (AMi); Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT (SSB); Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia (JLH); Cancer Prevention Institute of California (formerly the Northern California Cancer Center), Fremont and Stanford University School of Medicine, Stanford, CA (EMJ); Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, NY (MBT); Department of Dermatology, University of Utah, Utah (DGo); Department of Clinical Biochemistry (TvOH, LJ) and Department of Oncology (BE), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Pathology, University Hospital and University of Iceland School of Medicine, Reykjavik, Iceland (BAA); Clinical Genetics Service, Department of Medicine, Memorial Sloan- Kettering Cancer Center, New York, NY (KO, TK, JV, AVCD-C, JAP); Istituto Oncologico Veneto—IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy (MM, CC); N.N. Petrov Institute of Oncology, St-Petersburg, Russia (ENI); Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Vilnius, Lithuania (RJ); Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain (IB, CL); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (KBM); Women's Cancer Research Institute at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA (BYK, JG); University of California, San Francisco (UCSF) Cancer Risk Program and Department of Medicine, Department of Epidemiology, and Department of Biostatistics, UCSF, San Francisco, CA (MSB); Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany (RS, BW); Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany (AM); Department of Gynaecology and Obstetrics, Ludwig- Maximillians University Munich, Germany (IR); Institute of Human Genetics, University of Regensburg, Regensburg, Germany (BF); Institute of Human Genetics, Department of Human Genetics, Laboratory of Molecular Genetics, University of Heidelberg, Heidelberg, Germany (CS); Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany (NA); Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany (HD); Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany (RV-M); Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany (KK); Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany (DN); Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany (DG); Molecular Oncology Laboratory, Hospital San Carlos, Madrid, Spain (TC, MdlH); Helsinki University Central Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland (HN); Helsinki University Central Hospital, Department of Clinical Genetics, Helsinki, Finland (KA); Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada (JS, PS); Cancer Research United Kingdom Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom (DFE)